YPL019C / VTC3

Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL019C / VTC3

Click on Significant Values for Screen Details ID:SGTC_111|Compound:0083-0039|FD-Score:3.01|P-value:3.63E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.82|P-value:8.33E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.80|P-value:1.12E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.47|P-value:4.99E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:5.60|P-value:1.81E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:2.79|P-value:8.76E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:2.83|P-value:7.42E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.57|P-value:3.40E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:2.88|P-value:6.07E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.82|P-value:8.19E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.68|P-value:1.99E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.67|P-value:1.97E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.04|P-value:3.43E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.00|P-value:3.78E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.39|P-value:7.24E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.81|P-value:9.91E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-2.90|P-value:6.14E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-4.26|P-value:9.74E-7 ID:SGTC_1403|Compound:3909-7815|FD-Score:-2.78|P-value:9.49E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.44|P-value:5.69E-5 ID:SGTC_1628|Compound:st004252|FD-Score:2.92|P-value:5.26E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.49|P-value:4.81E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.56|P-value:3.46E-5 ID:SGTC_1799|Compound:st045822|FD-Score:2.79|P-value:8.64E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-2.87|P-value:6.91E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.79|P-value:9.33E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.96|P-value:4.42E-6 ID:SGTC_2378|Compound:9074213|FD-Score:-3.07|P-value:3.06E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.63|P-value:2.57E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.17|P-value:2.04E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.99|P-value:4.31E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-2.90|P-value:5.96E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.25|P-value:1.32E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2968|Compound:9090663|FD-Score:2.79|P-value:8.68E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:3.01|P-value:3.63E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.82|P-value:8.33E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.80|P-value:1.12E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.47|P-value:4.99E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:5.60|P-value:1.81E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:2.79|P-value:8.76E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:2.83|P-value:7.42E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.57|P-value:3.40E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:2.88|P-value:6.07E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.82|P-value:8.19E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.68|P-value:1.99E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.67|P-value:1.97E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.04|P-value:3.43E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.00|P-value:3.78E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.39|P-value:7.24E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.81|P-value:9.91E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-2.90|P-value:6.14E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-4.26|P-value:9.74E-7 ID:SGTC_1403|Compound:3909-7815|FD-Score:-2.78|P-value:9.49E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.44|P-value:5.69E-5 ID:SGTC_1628|Compound:st004252|FD-Score:2.92|P-value:5.26E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.49|P-value:4.81E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.56|P-value:3.46E-5 ID:SGTC_1799|Compound:st045822|FD-Score:2.79|P-value:8.64E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-2.87|P-value:6.91E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.79|P-value:9.33E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.96|P-value:4.42E-6 ID:SGTC_2378|Compound:9074213|FD-Score:-3.07|P-value:3.06E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.63|P-value:2.57E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.17|P-value:2.04E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.99|P-value:4.31E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-2.90|P-value:5.96E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.25|P-value:1.32E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2968|Compound:9090663|FD-Score:2.79|P-value:8.68E-4

Top fitness defect scores for YPL019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_747 3448-8087 5.60 38.7 µM 1.81E-10 4 1.09E-8
2 SGTC_2247 cerulenin 3.96 830.0 nM 4.42E-6 16 3.68E-5
3 SGTC_1209 2323-2347 3.81 50.3 µM 9.91E-6 19 7.05E-5
4 SGTC_1129 3453-1384 3.67 223.0 µM 1.97E-5 49 1.22E-4
5 SGTC_739 1486-1183 3.47 203.0 µM 4.99E-5 32 2.60E-4
6 SGTC_1453 4237-0541 3.44 195.0 µM 5.69E-5 heme biosynthesis & mitochondrial translocase 41 2.89E-4
7 SGTC_1208 2323-2347 3.39 50.3 µM 7.24E-5 19 3.51E-4
8 SGTC_2781 5567276 3.25 71.4 µM 1.32E-4 96 5.70E-4
9 SGTC_111 0083-0039 3.01 52.5 µM 3.63E-4 13 0.00129
10 SGTC_1203 3992-3522 3.00 103.0 µM 3.78E-4 87 0.00134
11 SGTC_1628 st004252 2.92 77.7 µM 5.26E-4 74 0.00175
12 SGTC_927 2425-1185 2.88 123.0 µM 6.07E-4 76 0.00196
13 SGTC_762 1165-0429 2.83 115.0 µM 7.42E-4 TSC3-RPN4 77 0.00231
14 SGTC_1799 st045822 2.79 46.1 µM 8.64E-4 63 0.00261
15 SGTC_2968 9090663 2.79 33.4 µM 8.68E-4 97 0.00262
16 SGTC_761 k216-0224 2.79 480.0 µM 8.76E-4 81 0.00264
17 SGTC_2770 toltrazuril 2.75 17.5 µM 0.00100 96 0.00294
18 SGTC_851 0394-0702 2.74 453.0 µM 0.00104 mitochondrial processes 68 0.00304
19 SGTC_2806 7952793 2.70 58.4 µM 0.00122 98 0.00345
20 SGTC_2301 7769476 2.68 200.0 µM 0.00131 73 0.00365

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.45E-16 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.133 9.05E-15 YFR023W PES4 hom Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication
0.109 2.14E-10 YDR338C_p YDR338C_p hom Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
0.105 8.89E-10 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 2.61E-9 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.101 4.82E-9 YMR229C RRP5 het RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress
0.100 7.08E-9 YGL260W_p YGL260W_p hom Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
0.098 1.32E-8 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.097 1.72E-8 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.097 1.76E-8 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.096 2.25E-8 YKL006W RPL14A hom Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication
0.094 5.20E-8 YKR032W_d YKR032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.10E-7 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.089 2.22E-7 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.088 2.89E-7 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology