HIPHOP chemogenomics database
YPL019C / VTC3 
Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPL019C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.141 | 2.45E-16 | YDR046C | BAP3 | hom | Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication |
| 0.133 | 9.05E-15 | YFR023W | PES4 | hom | Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication |
| 0.109 | 2.14E-10 | YDR338C_p | YDR338C_p | hom | Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily |
| 0.105 | 8.89E-10 | YJR098C_p | YJR098C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.103 | 2.61E-9 | YHR110W | ERP5 | hom | Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport |
| 0.101 | 4.82E-9 | YMR229C | RRP5 | het | RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress |
| 0.100 | 7.08E-9 | YGL260W_p | YGL260W_p | hom | Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium |
| 0.098 | 1.32E-8 | YDR379W | RGA2 | hom | GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p |
| 0.097 | 1.72E-8 | YGR017W_p | YGR017W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm |
| 0.097 | 1.76E-8 | YHL006C | SHU1 | hom | Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function |
| 0.096 | 2.25E-8 | YKL006W | RPL14A | hom | Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication |
| 0.094 | 5.20E-8 | YKR032W_d | YKR032W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.089 | 2.10E-7 | YAL062W | GDH3 | hom | NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication |
| 0.089 | 2.22E-7 | YMR288W | HSH155 | het | U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 |
| 0.088 | 2.89E-7 | YDR430C | CYM1 | hom | Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology |