YPL027W / SMA1

Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL027W / SMA1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:8.28|P-value:3.04E-20 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.10|P-value:1.14E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.25|P-value:1.87E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.02|P-value:4.08E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.41|P-value:9.33E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.13|P-value:3.13E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.85|P-value:7.95E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.31|P-value:1.22E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:2.87|P-value:7.20E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.23|P-value:1.67E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.20|P-value:2.29E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.66|P-value:3.09E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.93|P-value:6.78E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-2.89|P-value:7.77E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.32|P-value:1.16E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.04|P-value:3.67E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.17|P-value:2.20E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.09|P-value:3.09E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:2.97|P-value:4.97E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.18|P-value:2.10E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.59|P-value:4.26E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.81|P-value:8.97E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.95|P-value:5.36E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.53|P-value:4.67E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.78|P-value:1.43E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.71|P-value:2.46E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.58|P-value:4.53E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.93|P-value:5.64E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.06|P-value:3.43E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.75|P-value:1.62E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-5.79|P-value:1.08E-10 ID:SGTC_1724|Compound:st037281|FD-Score:-2.90|P-value:7.59E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.20|P-value:2.32E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.28|P-value:1.69E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.15|P-value:6.10E-9 ID:SGTC_2056|Compound:5235370|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-2.85|P-value:9.09E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.31|P-value:1.20E-4 ID:SGTC_2151|Compound:5563267|FD-Score:2.89|P-value:6.69E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.43|P-value:7.12E-5 ID:SGTC_2176|Compound:5809774|FD-Score:2.80|P-value:9.33E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-2.88|P-value:8.25E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.08|P-value:3.17E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.11|P-value:2.79E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.89|P-value:8.38E-6 ID:SGTC_2370|Compound:9071495|FD-Score:-3.04|P-value:4.40E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.20|P-value:2.35E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.55|P-value:2.32E-7 ID:SGTC_2516|Compound:gossypol|FD-Score:3.57|P-value:3.74E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:2.83|P-value:8.47E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.10|P-value:3.46E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.03|P-value:3.92E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-2.95|P-value:6.20E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.03|P-value:3.96E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.79|P-value:1.36E-5 ID:SGTC_2812|Compound:7970281|FD-Score:2.98|P-value:4.77E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.27|P-value:1.73E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.13|P-value:2.55E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.14|P-value:3.03E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.93|P-value:6.86E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.23|P-value:2.06E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.02|P-value:4.10E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.16|P-value:2.33E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:8.28|P-value:3.04E-20 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.10|P-value:1.14E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.25|P-value:1.87E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.02|P-value:4.08E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.41|P-value:9.33E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.13|P-value:3.13E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.85|P-value:7.95E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.31|P-value:1.22E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:2.87|P-value:7.20E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.23|P-value:1.67E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.20|P-value:2.29E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.66|P-value:3.09E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.93|P-value:6.78E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-2.89|P-value:7.77E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.32|P-value:1.16E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.04|P-value:3.67E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.17|P-value:2.20E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.09|P-value:3.09E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:2.97|P-value:4.97E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.18|P-value:2.10E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.59|P-value:4.26E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.81|P-value:8.97E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.95|P-value:5.36E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.53|P-value:4.67E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.78|P-value:1.43E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.71|P-value:2.46E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.58|P-value:4.53E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.93|P-value:5.64E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.06|P-value:3.43E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.75|P-value:1.62E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-5.79|P-value:1.08E-10 ID:SGTC_1724|Compound:st037281|FD-Score:-2.90|P-value:7.59E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.20|P-value:2.32E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.28|P-value:1.69E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.15|P-value:6.10E-9 ID:SGTC_2056|Compound:5235370|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-2.85|P-value:9.09E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.31|P-value:1.20E-4 ID:SGTC_2151|Compound:5563267|FD-Score:2.89|P-value:6.69E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.43|P-value:7.12E-5 ID:SGTC_2176|Compound:5809774|FD-Score:2.80|P-value:9.33E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-2.88|P-value:8.25E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.08|P-value:3.17E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.11|P-value:2.79E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.89|P-value:8.38E-6 ID:SGTC_2370|Compound:9071495|FD-Score:-3.04|P-value:4.40E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.20|P-value:2.35E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.55|P-value:2.32E-7 ID:SGTC_2516|Compound:gossypol|FD-Score:3.57|P-value:3.74E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:2.83|P-value:8.47E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.10|P-value:3.46E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.03|P-value:3.92E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-2.95|P-value:6.20E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.03|P-value:3.96E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.79|P-value:1.36E-5 ID:SGTC_2812|Compound:7970281|FD-Score:2.98|P-value:4.77E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.27|P-value:1.73E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.13|P-value:2.55E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.14|P-value:3.03E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.93|P-value:6.86E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.23|P-value:2.06E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.02|P-value:4.10E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.16|P-value:2.33E-4

Top fitness defect scores for YPL027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 8.28 35.0 µM 3.04E-20 calcium & mitochondrial duress 13 6.18E-17
2 SGTC_2050 5263056 5.15 171.0 µM 6.10E-9 fatty acid desaturase (OLE1) 24 1.30E-7
3 SGTC_2514 salinomycin 4.55 42.7 µM 2.32E-7 30 2.63E-6
4 SGTC_2310 7668677 3.89 200.0 µM 8.38E-6 31 5.09E-5
5 SGTC_2793 7325131 3.79 81.8 µM 1.36E-5 19 7.62E-5
6 SGTC_1186 1319-0216 3.78 26.0 µM 1.43E-5 22 7.93E-5
7 SGTC_1528 arabinosylhypoxanthine 3.75 74.6 µM 1.62E-5 29 8.78E-5
8 SGTC_2516 gossypol 3.57 71.5 µM 3.74E-5 24 1.76E-4
9 SGTC_1145 3546-0597 3.53 10.2 µM 4.67E-5 mitochondrial processes 30 2.11E-4
10 SGTC_2166 5933061 3.43 31.5 µM 7.12E-5 tubulin folding & SWR complex 58 2.99E-4
11 SGTC_687 k029-0044 3.34 34.9 µM 1.08E-4 PDR1 35 4.23E-4
12 SGTC_686 1319-0111 3.32 510.0 µM 1.16E-4 60S ribosome export 50 4.49E-4
13 SGTC_2143 5623677 3.31 140.5 µM 1.20E-4 15 4.63E-4
14 SGTC_340 k038-0059 3.31 454.0 µM 1.22E-4 ubiquinone biosynthesis & proteasome 65 4.70E-4
15 SGTC_515 4092-1064 3.23 102.0 µM 1.67E-4 plasma membrane duress 86 6.09E-4
16 SGTC_1008 4106-0037 3.18 6.0 µM 2.10E-4 PDR1 40 7.33E-4
17 SGTC_751 0833-0568 3.17 350.0 µM 2.20E-4 53 7.65E-4
18 SGTC_3306 9127676 3.16 59.8 µM 2.33E-4 53 8.01E-4
19 SGTC_2967 9089538 3.13 49.9 µM 2.55E-4 72 8.63E-4
20 SGTC_2207 7258803 3.11 200.0 µM 2.79E-4 27 9.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.63E-25 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.177 5.22E-25 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.169 7.59E-23 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.166 2.92E-22 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.153 4.92E-19 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.147 1.07E-17 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.133 1.26E-14 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.127 1.74E-13 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.122 1.07E-12 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.120 2.60E-12 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.120 3.08E-12 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.119 4.24E-12 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.118 8.11E-12 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.117 1.20E-11 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 8.21E-11 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly