YPL028W / ERG10

Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL028W / ERG10

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:2.98|P-value:6.37E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.17|P-value:3.82E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.99|P-value:7.35E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.35|P-value:1.86E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:5.02|P-value:3.23E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:3.44|P-value:9.92E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:4.49|P-value:6.35E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.94|P-value:9.03E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.22|P-value:2.53E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.06|P-value:5.67E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.39|P-value:1.23E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:14.30|P-value:1.53E-53 ID:SGTC_565|Compound:1418-0001|FD-Score:4.19|P-value:3.10E-6 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.77|P-value:2.98E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.73|P-value:2.80E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.04|P-value:6.32E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.49|P-value:8.10E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.11|P-value:3.82E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.98|P-value:3.93E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:3.42|P-value:1.09E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:6.37|P-value:3.64E-12 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.97|P-value:9.05E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.27|P-value:2.58E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.19|P-value:3.53E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-2.99|P-value:7.41E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.16|P-value:4.00E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.67|P-value:2.38E-7 ID:SGTC_1611|Compound:st001856|FD-Score:3.95|P-value:9.89E-6 ID:SGTC_1646|Compound:st011709|FD-Score:3.05|P-value:4.90E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-2.95|P-value:8.73E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.45|P-value:9.52E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.81|P-value:1.97E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.64|P-value:4.29E-5 ID:SGTC_1780|Compound:st038448|FD-Score:-3.22|P-value:3.12E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.96|P-value:6.73E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.21|P-value:2.63E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.00|P-value:7.08E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.78|P-value:2.23E-5 ID:SGTC_2031|Compound:5180455|FD-Score:-3.12|P-value:4.56E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.95|P-value:7.22E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.57|P-value:5.89E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.33|P-value:1.63E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.39|P-value:1.57E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.11|P-value:3.89E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.79|P-value:2.15E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.90|P-value:1.02E-17 ID:SGTC_2543|Compound:pimpinellin|FD-Score:2.87|P-value:9.35E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.49|P-value:8.18E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.45|P-value:9.65E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.53|P-value:8.64E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.93|P-value:1.09E-5 ID:SGTC_2868|Compound:9035608|FD-Score:4.58|P-value:4.01E-7 ID:SGTC_3304|Compound:9125678|FD-Score:3.69|P-value:3.46E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.02|P-value:5.45E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.98|P-value:6.37E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.17|P-value:3.82E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.99|P-value:7.35E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.35|P-value:1.86E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:5.02|P-value:3.23E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:3.44|P-value:9.92E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:4.49|P-value:6.35E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.94|P-value:9.03E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.22|P-value:2.53E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.06|P-value:5.67E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.39|P-value:1.23E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:14.30|P-value:1.53E-53 ID:SGTC_565|Compound:1418-0001|FD-Score:4.19|P-value:3.10E-6 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.77|P-value:2.98E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.73|P-value:2.80E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.04|P-value:6.32E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.49|P-value:8.10E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.11|P-value:3.82E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.98|P-value:3.93E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:3.42|P-value:1.09E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:6.37|P-value:3.64E-12 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.97|P-value:9.05E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.27|P-value:2.58E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.19|P-value:3.53E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-2.99|P-value:7.41E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.16|P-value:4.00E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.67|P-value:2.38E-7 ID:SGTC_1611|Compound:st001856|FD-Score:3.95|P-value:9.89E-6 ID:SGTC_1646|Compound:st011709|FD-Score:3.05|P-value:4.90E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-2.95|P-value:8.73E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.45|P-value:9.52E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.81|P-value:1.97E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.64|P-value:4.29E-5 ID:SGTC_1780|Compound:st038448|FD-Score:-3.22|P-value:3.12E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.96|P-value:6.73E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.21|P-value:2.63E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.00|P-value:7.08E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.78|P-value:2.23E-5 ID:SGTC_2031|Compound:5180455|FD-Score:-3.12|P-value:4.56E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.95|P-value:7.22E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.57|P-value:5.89E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.33|P-value:1.63E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.39|P-value:1.57E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.11|P-value:3.89E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.79|P-value:2.15E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.90|P-value:1.02E-17 ID:SGTC_2543|Compound:pimpinellin|FD-Score:2.87|P-value:9.35E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.49|P-value:8.18E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.45|P-value:9.65E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.53|P-value:8.64E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.93|P-value:1.09E-5 ID:SGTC_2868|Compound:9035608|FD-Score:4.58|P-value:4.01E-7 ID:SGTC_3304|Compound:9125678|FD-Score:3.69|P-value:3.46E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.02|P-value:5.45E-4

Top fitness defect scores for YPL028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_451 chloral hydrate 14.30 100.0 µM 1.53E-53 3 1.03E-46 7.67
2 SGTC_2541 muurolladie-3-one 7.90 83.1 µM 1.02E-17 excess fatty acid 2 1.43E-15 0.87
3 SGTC_969 1313-0238 6.37 134.0 µM 3.64E-12 mitochondrial processes 4 9.68E-11 0.43
4 SGTC_99 0109-0120 5.02 622.8 µM 3.23E-8 2 2.63E-7 0.73
5 SGTC_769 0302-0231 4.98 76.0 µM 3.93E-8 6 3.12E-7 0.34
6 SGTC_1525 8-methoxypsoralen 4.67 92.5 µM 2.38E-7 DNA damage response 9 1.50E-6 0.23
7 SGTC_2868 9035608 4.58 32.5 µM 4.01E-7 1 2.36E-6 0.50
8 SGTC_116 0155-0182 4.49 31.8 µM 6.35E-7 mitochondrial response to ROS 2 3.51E-6 0.63
9 SGTC_565 1418-0001 4.19 44.5 µM 3.10E-6 5 1.40E-5 0.66
10 SGTC_1083 didemethylchlorpromazine sulfoxide 3.97 707.4 nM 9.05E-6 redox potentiating 23 3.55E-5 0.03
11 SGTC_1611 st001856 3.95 99.4 µM 9.89E-6 6 3.83E-5 0.05
12 SGTC_2809 7964133 3.93 13.0 µM 1.09E-5 60S ribosome export 13 4.16E-5 0.08
13 SGTC_1675 st018485 3.81 24.5 µM 1.97E-5 60S ribosome export 11 6.98E-5 0.18
14 SGTC_2437 5741531 3.79 144.2 µM 2.15E-5 8 7.54E-5 0.26
15 SGTC_2027 5150920 3.78 200.0 µM 2.23E-5 3 7.79E-5 0.28
16 SGTC_716 1683-5115 3.73 658.0 µM 2.80E-5 3 9.48E-5 0.08
17 SGTC_3304 9125678 3.69 46.1 µM 3.46E-5 29 1.14E-4 0.10
18 SGTC_1741 st038134 3.64 10.2 µM 4.29E-5 6 1.38E-4 0.11
19 SGTC_2101 5377231 3.57 179.2 µM 5.89E-5 8 1.81E-4 0.17
20 SGTC_745 0469-0705 3.49 296.0 µM 8.10E-5 mitochondrial processes 30 2.40E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 2.55E-45 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.239 7.76E-45 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.136 2.37E-15 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.134 5.93E-15 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.133 9.41E-15 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.120 2.66E-12 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.119 4.24E-12 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.112 8.15E-11 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.111 1.18E-10 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.111 1.19E-10 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.110 1.44E-10 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.106 8.17E-10 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.104 1.41E-9 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.101 3.96E-9 YDL075W RPL31A hom Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication
0.101 5.33E-9 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)