YPL036W / PMA2

Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL036W / PMA2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.23|P-value:1.22E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.28|P-value:1.02E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:2.76|P-value:8.93E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.99|P-value:7.24E-9 ID:SGTC_894|Compound:0960-0238|FD-Score:3.16|P-value:1.71E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:5.68|P-value:6.16E-11 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.86|P-value:5.78E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.84|P-value:6.35E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-2.81|P-value:7.24E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.12|P-value:3.12E-9 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.88|P-value:5.46E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-2.78|P-value:7.85E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.17|P-value:1.60E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.07|P-value:2.55E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.57|P-value:1.13E-7 ID:SGTC_1947|Compound:st076332|FD-Score:-3.72|P-value:1.20E-5 ID:SGTC_2281|Compound:7943571|FD-Score:4.01|P-value:2.72E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.14|P-value:1.89E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-2.76|P-value:8.56E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.43|P-value:4.96E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.06|P-value:2.56E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.97|P-value:3.84E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.04|P-value:2.27E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.72|P-value:1.24E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.22|P-value:1.33E-4 ID:SGTC_2969|Compound:9091408|FD-Score:2.90|P-value:5.13E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.68|P-value:1.52E-5 ID:SGTC_2989|Compound:9073649|FD-Score:9.43|P-value:5.34E-27 ID:SGTC_2991|Compound:9074669|FD-Score:5.25|P-value:1.30E-9 ID:SGTC_2998|Compound:9066762|FD-Score:3.95|P-value:3.82E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.85|P-value:6.40E-6 ID:SGTC_3129|Compound:9127257|FD-Score:-4.00|P-value:2.84E-6 ID:SGTC_3289|Compound:9119912|FD-Score:-2.82|P-value:6.91E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.23|P-value:1.22E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.28|P-value:1.02E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:2.76|P-value:8.93E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.99|P-value:7.24E-9 ID:SGTC_894|Compound:0960-0238|FD-Score:3.16|P-value:1.71E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:5.68|P-value:6.16E-11 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.86|P-value:5.78E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.84|P-value:6.35E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-2.81|P-value:7.24E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.12|P-value:3.12E-9 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.88|P-value:5.46E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-2.78|P-value:7.85E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.17|P-value:1.60E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.07|P-value:2.55E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.57|P-value:1.13E-7 ID:SGTC_1947|Compound:st076332|FD-Score:-3.72|P-value:1.20E-5 ID:SGTC_2281|Compound:7943571|FD-Score:4.01|P-value:2.72E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.14|P-value:1.89E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-2.76|P-value:8.56E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.43|P-value:4.96E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.06|P-value:2.56E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.97|P-value:3.84E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.04|P-value:2.27E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.72|P-value:1.24E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.22|P-value:1.33E-4 ID:SGTC_2969|Compound:9091408|FD-Score:2.90|P-value:5.13E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.68|P-value:1.52E-5 ID:SGTC_2989|Compound:9073649|FD-Score:9.43|P-value:5.34E-27 ID:SGTC_2991|Compound:9074669|FD-Score:5.25|P-value:1.30E-9 ID:SGTC_2998|Compound:9066762|FD-Score:3.95|P-value:3.82E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.85|P-value:6.40E-6 ID:SGTC_3129|Compound:9127257|FD-Score:-4.00|P-value:2.84E-6 ID:SGTC_3289|Compound:9119912|FD-Score:-2.82|P-value:6.91E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.19|P-value:1.44E-4

Top fitness defect scores for YPL036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2989 9073649 9.43 71.4 µM 5.34E-27 2 2.02E-21
2 SGTC_896 0964-0007 5.68 44.5 µM 6.16E-11 4 6.90E-9
3 SGTC_2991 9074669 5.25 71.4 µM 1.30E-9 azole & statin 27 7.49E-8
4 SGTC_1756 st041558 4.57 35.5 µM 1.13E-7 5 2.48E-6
5 SGTC_2622 2-methoxyxanthone 4.04 59.9 µM 2.27E-6 17 2.62E-5
6 SGTC_2281 7943571 4.01 200.0 µM 2.72E-6 9 3.02E-5
7 SGTC_2998 9066762 3.95 71.4 µM 3.82E-6 RPP1 & pyrimidine depletion 26 3.95E-5
8 SGTC_3063 1327-0034 3.85 4.0 µM 6.40E-6 48 5.92E-5
9 SGTC_2794 7785382 3.72 27.3 µM 1.24E-5 47 9.96E-5
10 SGTC_2987 9018338 3.68 71.4 µM 1.52E-5 RPP1 & pyrimidine depletion 28 1.17E-4
11 SGTC_2487 5918373 3.43 44.0 µM 4.96E-5 30 2.97E-4
12 SGTC_41 0478-0632 3.28 82.6 µM 1.00E-4 58 5.17E-4
13 SGTC_284 0988-0104 3.28 32.6 µM 1.02E-4 heme requiring 25 5.25E-4
14 SGTC_2880 9042983 3.22 58.4 µM 1.33E-4 fatty acid desaturase (OLE1) 54 6.47E-4
15 SGTC_894 0960-0238 3.16 55.9 µM 1.71E-4 32 7.90E-4
16 SGTC_2288 7946289 3.14 167.3 µM 1.89E-4 68 8.56E-4
17 SGTC_1751 st044839 3.07 27.2 µM 2.55E-4 Golgi 28 0.00108
18 SGTC_2621 lithochol-11-enic acid 2.97 100.0 µM 3.84E-4 81 0.00150
19 SGTC_2969 9091408 2.90 28.7 µM 5.13E-4 88 0.00188
20 SGTC_1263 0774-1208 2.88 64.8 µM 5.46E-4 125 0.00198

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.275 3.23E-59 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.210 6.93E-35 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.209 1.77E-34 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.207 7.82E-34 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.200 1.54E-31 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.184 4.30E-27 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.182 1.75E-26 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.179 1.57E-25 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.179 1.63E-25 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.177 4.79E-25 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.171 2.67E-23 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.167 2.21E-22 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.167 2.45E-22 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.165 6.08E-22 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.164 1.26E-21 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome