YPL038W / MET31

Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL038W / MET31

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.35|P-value:5.61E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.07|P-value:3.94E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.70|P-value:1.67E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.45|P-value:4.03E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.78|P-value:1.80E-6 ID:SGTC_295|Compound:k015-0027|FD-Score:3.21|P-value:9.08E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.38|P-value:9.49E-8 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.72|P-value:1.51E-4 ID:SGTC_456|Compound:gingerol|FD-Score:4.52|P-value:5.74E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.94|P-value:6.48E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.58|P-value:2.54E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.25|P-value:7.83E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.47|P-value:4.46E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.63|P-value:2.55E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.69|P-value:2.04E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.18|P-value:9.89E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.39|P-value:5.78E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.44|P-value:4.91E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.40|P-value:5.55E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.71|P-value:1.86E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-7.32|P-value:9.43E-13 ID:SGTC_1720|Compound:st037298|FD-Score:6.32|P-value:4.69E-10 ID:SGTC_1733|Compound:st037357|FD-Score:-3.39|P-value:5.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.99|P-value:5.33E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.47|P-value:3.80E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.31|P-value:6.50E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.97|P-value:5.88E-5 ID:SGTC_2367|Compound:9070478|FD-Score:6.22|P-value:8.70E-10 ID:SGTC_2378|Compound:9074213|FD-Score:3.45|P-value:4.00E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.53|P-value:5.52E-6 ID:SGTC_2433|Compound:5607874|FD-Score:4.85|P-value:1.28E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.23|P-value:2.00E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.08|P-value:3.84E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.82|P-value:1.22E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.45|P-value:7.84E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.99|P-value:6.45E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-5.11|P-value:4.65E-7 ID:SGTC_3095|Compound:9117207|FD-Score:3.23|P-value:8.37E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.35|P-value:5.61E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.07|P-value:3.94E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.70|P-value:1.67E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.45|P-value:4.03E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.78|P-value:1.80E-6 ID:SGTC_295|Compound:k015-0027|FD-Score:3.21|P-value:9.08E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.38|P-value:9.49E-8 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.72|P-value:1.51E-4 ID:SGTC_456|Compound:gingerol|FD-Score:4.52|P-value:5.74E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.94|P-value:6.48E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.58|P-value:2.54E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.25|P-value:7.83E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.47|P-value:4.46E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.63|P-value:2.55E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.69|P-value:2.04E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.18|P-value:9.89E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.39|P-value:5.78E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.44|P-value:4.91E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.40|P-value:5.55E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.71|P-value:1.86E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-7.32|P-value:9.43E-13 ID:SGTC_1720|Compound:st037298|FD-Score:6.32|P-value:4.69E-10 ID:SGTC_1733|Compound:st037357|FD-Score:-3.39|P-value:5.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.99|P-value:5.33E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.47|P-value:3.80E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.31|P-value:6.50E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.97|P-value:5.88E-5 ID:SGTC_2367|Compound:9070478|FD-Score:6.22|P-value:8.70E-10 ID:SGTC_2378|Compound:9074213|FD-Score:3.45|P-value:4.00E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.53|P-value:5.52E-6 ID:SGTC_2433|Compound:5607874|FD-Score:4.85|P-value:1.28E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.23|P-value:2.00E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.08|P-value:3.84E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.82|P-value:1.22E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.45|P-value:7.84E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.99|P-value:6.45E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-5.11|P-value:4.65E-7 ID:SGTC_3095|Compound:9117207|FD-Score:3.23|P-value:8.37E-4

Top fitness defect scores for YPL038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 6.32 9.5 µM 4.69E-10 11 1.31E-10
2 SGTC_2367 9070478 6.22 135.4 µM 8.70E-10 cell wall 10 2.53E-10
3 SGTC_361 000s-0510 5.38 1.4 µM 9.49E-8 10 3.80E-8
4 SGTC_2433 5607874 4.85 27.8 µM 1.28E-6 5 6.13E-7
5 SGTC_184 1494-0393 4.78 24.7 µM 1.80E-6 37 8.78E-7
6 SGTC_2396 5342950 4.53 42.8 µM 5.52E-6 RSC complex & mRNA processing 28 2.91E-6
7 SGTC_456 gingerol 4.52 170.0 µM 5.74E-6 9 3.03E-6
8 SGTC_2573 2',4'-dihydroxychalcone 4.45 15.0 µM 7.84E-6 33 4.22E-6
9 SGTC_2499 avocadenofuran 4.23 51.5 µM 2.00E-5 28 1.14E-5
10 SGTC_2507 purpurin 4.08 79.7 µM 3.84E-5 copper-dependent oxidative stress 32 2.30E-5
11 SGTC_126 0417-1624 4.07 672.5 µM 3.94E-5 DNA intercalators 28 2.36E-5
12 SGTC_1926 methyl fluorone black 3.99 53.6 µM 5.33E-5 DNA intercalators 59 3.26E-5
13 SGTC_2346 9031566 3.97 143.8 µM 5.88E-5 Golgi 16 3.62E-5
14 SGTC_514 4466-0038 3.94 2.6 nM 6.48E-5 cell wall 158 4.01E-5
15 SGTC_1134 3477-0009 3.83 42.5 µM 1.02E-4 48 6.50E-5
16 SGTC_388 3',4'-dichloroisocoumarin 3.72 16.7 µM 1.51E-4 19 9.85E-5
17 SGTC_145 3737-0113 3.70 38.4 µM 1.67E-4 DNA intercalators 86 1.10E-4
18 SGTC_628 1636-0253 3.58 16.0 µM 2.54E-4 sphingolipid biosynthesis & PDR1 46 1.72E-4
19 SGTC_2127 5253358 3.47 187.9 µM 3.80E-4 39 2.63E-4
20 SGTC_2378 9074213 3.45 121.4 µM 4.00E-4 RSC complex & mRNA processing 35 2.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 6.16E-30 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.156 1.26E-19 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.139 5.98E-16 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.131 2.12E-14 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.121 1.90E-12 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.115 2.42E-11 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.113 5.52E-11 YHL044W_p YHL044W_p hom Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
0.112 9.40E-11 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.110 1.95E-10 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.109 2.76E-10 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.107 4.71E-10 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.107 5.61E-10 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.106 7.19E-10 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.105 1.15E-9 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.104 1.44E-9 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication