YPL041C_p

Protein of unknown function involved in maintenance of proper telomere length

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL041C / YPL041C

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.13|P-value:9.80E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.41|P-value:3.07E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.48|P-value:2.37E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.70|P-value:1.56E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.26|P-value:6.26E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.12|P-value:2.22E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.23|P-value:5.82E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.08|P-value:9.89E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-5.04|P-value:2.86E-7 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.46|P-value:3.13E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.28|P-value:5.86E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.39|P-value:4.01E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.34|P-value:4.82E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.76|P-value:9.85E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-4.18|P-value:1.70E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.74|P-value:1.08E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.75|P-value:1.02E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.41|P-value:3.77E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.20|P-value:7.68E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.30|P-value:5.47E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.10|P-value:9.13E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.43|P-value:2.83E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.28|P-value:5.95E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.84|P-value:8.02E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.11|P-value:8.73E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.33|P-value:4.17E-4 ID:SGTC_3250|Compound:9135583|FD-Score:5.00|P-value:2.65E-7 ID:SGTC_3333|Compound:9141820|FD-Score:3.32|P-value:4.20E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.13|P-value:9.80E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.41|P-value:3.07E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.48|P-value:2.37E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.70|P-value:1.56E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.26|P-value:6.26E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.12|P-value:2.22E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.23|P-value:5.82E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.08|P-value:9.89E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-5.04|P-value:2.86E-7 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.46|P-value:3.13E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.28|P-value:5.86E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.39|P-value:4.01E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.34|P-value:4.82E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.76|P-value:9.85E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-4.18|P-value:1.70E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.74|P-value:1.08E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.75|P-value:1.02E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.41|P-value:3.77E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.20|P-value:7.68E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.30|P-value:5.47E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.10|P-value:9.13E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.43|P-value:2.83E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.28|P-value:5.95E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.84|P-value:8.02E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.11|P-value:8.73E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.33|P-value:4.17E-4 ID:SGTC_3250|Compound:9135583|FD-Score:5.00|P-value:2.65E-7 ID:SGTC_3333|Compound:9141820|FD-Score:3.32|P-value:4.20E-4

Top fitness defect scores for YPL041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3250 9135583 5.00 49.5 µM 2.65E-7 3 2.80E-7
2 SGTC_1911 st060208 3.50 74.3 µM 2.17E-4 46 2.30E-4
3 SGTC_124 0136-0217 3.48 7.1 µM 2.37E-4 mitochondrial stress 73 2.51E-4
4 SGTC_2868 9035608 3.43 32.5 µM 2.83E-4 33 3.00E-4
5 SGTC_122 0236-0016 3.41 402.4 µM 3.07E-4 RNA processing & uracil transport 60 3.25E-4
6 SGTC_3151 9099821 3.33 49.5 µM 4.17E-4 42 4.41E-4
7 SGTC_3333 9141820 3.32 12.1 µM 4.20E-4 30 4.44E-4
8 SGTC_902 1120-0002 3.23 2.1 µM 5.82E-4 azole & statin 77 6.16E-4
9 SGTC_3126 9127922 3.11 49.5 µM 8.73E-4 fatty acid desaturase (OLE1) 77 9.24E-4
10 SGTC_2815 7968870 3.10 71.4 µM 9.13E-4 70 9.65E-4
11 SGTC_909 3448-9333 3.08 149.0 µM 9.89E-4 44 0.00105
12 SGTC_3104 9120930 3.06 49.5 µM 0.00104 41 0.00110
13 SGTC_215 1287-0124 3.06 461.5 µM 0.00106 14 0.00112
14 SGTC_1353 1498-1206 3.01 8.1 µM 0.00125 mitochondrial response to ROS 109 0.00133
15 SGTC_3197 9113331 2.99 49.5 µM 0.00131 94 0.00139
16 SGTC_1198 1612-1005 2.95 86.7 µM 0.00149 53 0.00157
17 SGTC_2813 7971799 2.92 71.4 µM 0.00164 71 0.00173
18 SGTC_208 k072-0098 2.84 12.4 µM 0.00216 heme biosynthesis & mitochondrial translocase 121 0.00229
19 SGTC_439 amiodarone 2.83 34.4 µM 0.00221 NEO1-PIK1 172 0.00233
20 SGTC_3258 9138477 2.82 49.5 µM 0.00228 56 0.00240

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.63E-28 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.129 6.75E-14 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.128 1.16E-13 YDL083C RPS16B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.121 2.02E-12 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.106 8.32E-10 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.102 2.76E-9 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.101 4.38E-9 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.099 1.09E-8 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.094 5.92E-8 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.087 4.44E-7 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 4.38E-7 YER082C UTP7 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.081 2.95E-6 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.080 3.88E-6 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.080 4.05E-6 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.078 6.62E-6 YBR283C SSH1 hom Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential