YPL048W / CAM1

Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL048W / CAM1

Click on Significant Values for Screen Details ID:SGTC_109|Compound:0132-0036|FD-Score:-3.69|P-value:1.06E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-4.31|P-value:7.59E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:3.15|P-value:8.78E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.24|P-value:5.77E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.19|P-value:7.61E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.44|P-value:3.04E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.70|P-value:1.16E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.11|P-value:9.98E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.70|P-value:1.14E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.12|P-value:1.67E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.15|P-value:7.70E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.56|P-value:1.95E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.49|P-value:2.57E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.56|P-value:1.94E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.87|P-value:5.78E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.26|P-value:5.96E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.88|P-value:5.60E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.38|P-value:6.44E-6 ID:SGTC_1994|Compound:st072947|FD-Score:3.35|P-value:4.34E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.15|P-value:7.69E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.57|P-value:2.63E-6 ID:SGTC_2146|Compound:5545642|FD-Score:3.14|P-value:8.83E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.40|P-value:3.58E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.29|P-value:5.28E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.89|P-value:5.46E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.39|P-value:3.78E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.88|P-value:5.63E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.25|P-value:6.10E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.60|P-value:1.67E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.21|P-value:6.29E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.21|P-value:6.97E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.34|P-value:4.39E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.96|P-value:3.92E-7 ID:SGTC_3300|Compound:9124615|FD-Score:3.63|P-value:1.48E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.69|P-value:1.06E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-4.31|P-value:7.59E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:3.15|P-value:8.78E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.24|P-value:5.77E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.19|P-value:7.61E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.44|P-value:3.04E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.70|P-value:1.16E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.11|P-value:9.98E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.70|P-value:1.14E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.12|P-value:1.67E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.15|P-value:7.70E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.56|P-value:1.95E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.49|P-value:2.57E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.56|P-value:1.94E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.87|P-value:5.78E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.26|P-value:5.96E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.88|P-value:5.60E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.38|P-value:6.44E-6 ID:SGTC_1994|Compound:st072947|FD-Score:3.35|P-value:4.34E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.15|P-value:7.69E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.57|P-value:2.63E-6 ID:SGTC_2146|Compound:5545642|FD-Score:3.14|P-value:8.83E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.40|P-value:3.58E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.29|P-value:5.28E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.89|P-value:5.46E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.39|P-value:3.78E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.88|P-value:5.63E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.25|P-value:6.10E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.60|P-value:1.67E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.21|P-value:6.29E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.21|P-value:6.97E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.34|P-value:4.39E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.96|P-value:3.92E-7 ID:SGTC_3300|Compound:9124615|FD-Score:3.63|P-value:1.48E-4

Top fitness defect scores for YPL048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1032 k061-1018 5.12 98.7 µM 1.67E-7 7 1.52E-7
2 SGTC_3194 9111903 4.96 49.5 µM 3.92E-7 8 3.59E-7
3 SGTC_2024 5144227 4.57 134.0 µM 2.63E-6 24 2.42E-6
4 SGTC_1860 st056228 4.38 74.6 µM 6.44E-6 8 5.95E-6
5 SGTC_2517 totarol 3.89 10.0 µM 5.46E-5 22 5.10E-5
6 SGTC_1851 st056236 3.88 18.9 µM 5.60E-5 17 5.22E-5
7 SGTC_2829 7992743 3.88 58.4 µM 5.63E-5 41 5.25E-5
8 SGTC_1681 tripelennamine 3.87 100.0 µM 5.78E-5 23 5.39E-5
9 SGTC_2335 9018011 3.72 154.2 µM 1.05E-4 32 9.83E-5
10 SGTC_1010 4112-3296 3.70 15.2 µM 1.14E-4 22 1.07E-4
11 SGTC_770 0389-1121 3.70 67.2 µM 1.16E-4 RPP1 & pyrimidine depletion 34 1.08E-4
12 SGTC_3300 9124615 3.63 50.5 µM 1.48E-4 25 1.39E-4
13 SGTC_2882 9058044 3.60 58.4 µM 1.67E-4 23 1.57E-4
14 SGTC_1453 4237-0541 3.56 195.0 µM 1.94E-4 heme biosynthesis & mitochondrial translocase 36 1.82E-4
15 SGTC_1042 0350-0096 3.56 82.0 µM 1.95E-4 TSC3-RPN4 37 1.83E-4
16 SGTC_1136 pergolide 3.49 1.1 µM 2.57E-4 60 2.42E-4
17 SGTC_754 3474-0146 3.44 171.0 µM 3.04E-4 copper-dependent oxidative stress 41 2.86E-4
18 SGTC_2241 6772625 3.40 37.8 µM 3.58E-4 45 3.37E-4
19 SGTC_2647 atorvastatin 3.39 60.2 µM 3.78E-4 azole & statin 32 3.55E-4
20 SGTC_1637 st007924 3.35 17.4 µM 4.32E-4 49 4.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.79E-9 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.093 6.10E-8 YKL120W OAC1 hom Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.092 9.97E-8 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.086 6.27E-7 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.083 1.59E-6 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.077 8.12E-6 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.076 1.03E-5 YNL266W_d YNL266W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C
0.076 1.19E-5 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.075 1.55E-5 YNL308C KRI1 het Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
0.074 1.72E-5 YMR318C ADH6 hom NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress
0.073 2.34E-5 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.071 3.81E-5 YLR423C ATG17 hom Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells
0.070 5.05E-5 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.070 5.38E-5 YMR066W SOV1 hom Mitochondrial protein of unknown function
0.070 5.57E-5 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress