HIPHOP chemogenomics database

YPL067C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL067C / YPL067C

Click on Significant Values for Screen Details

Top fitness defect scores for YPL067C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_453	enantio-paf c16	5.81	10.0 µM	1.04E-9		58	3.06E-9
2	SGTC_1908	st060353	4.68	56.5 µM	6.92E-7	RPP1 & pyrimidine depletion	24	1.44E-6
3	SGTC_2989	9073649	4.57	71.4 µM	1.18E-6		19	2.40E-6
4	SGTC_551	k048-0028	4.55	34.9 µM	1.35E-6		5	2.72E-6
5	SGTC_1914	st062367	4.29	72.6 µM	4.83E-6		17	9.08E-6
6	SGTC_278	4092-0821	3.92	23.9 µM	2.55E-5	plasma membrane duress	43	4.39E-5
7	SGTC_1270	0831-1170	3.86	17.3 µM	3.33E-5		11	5.65E-5
8	SGTC_722	3534-0461	3.78	190.0 µM	4.69E-5	PDR1	41	7.81E-5
9	SGTC_725	1497-0963	3.59	19.0 µM	1.02E-4	copper-dependent oxidative stress	28	1.63E-4
10	SGTC_291	4130-1278	3.59	35.5 µM	1.05E-4	Golgi	24	1.67E-4
11	SGTC_2167	5876490	3.42	200.0 µM	2.05E-4		52	3.15E-4
12	SGTC_730	1436-0052	3.40	41.2 µM	2.20E-4	mitochondrial processes	24	3.38E-4
13	SGTC_563	tetrahydrosecaminediol	3.34	614.0 µM	2.74E-4	amide catabolism	27	4.15E-4
14	SGTC_1258	0671-0043	3.33	57.1 µM	2.86E-4		50	4.32E-4
15	SGTC_3230	9131665	3.31	49.5 µM	3.10E-4		3	4.67E-4
16	SGTC_387	norethindrone acetate	3.28	66.7 µM	3.48E-4		39	5.20E-4
17	SGTC_1731	st035964	3.23	63.0 µM	4.16E-4		60	6.16E-4
18	SGTC_65	0798-0905	3.17	35.0 µM	5.20E-4	calcium & mitochondrial duress	143	7.61E-4
19	SGTC_2037	5169046	3.16	200.0 µM	5.35E-4	60S ribosome export	32	7.81E-4
20	SGTC_3153	9100258	3.13	49.5 µM	5.96E-4		63	8.65E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.174	3.90E-24	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.161	7.97E-21	YPL036W	PMA2	hom	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.160	8.93E-21	YLR016C	PML1	hom	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.159	1.94E-20	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.154	3.15E-19	YML101C-A_d	YML101C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148	7.06E-18	YER071C_p	TDA2_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.141	2.30E-16	YMR039C	SUB1	hom	Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.140	3.96E-16	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.140	4.42E-16	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.128	1.06E-13	YKL187C	FAT3	hom	Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.120	2.62E-12	YLR353W	BUD8	hom	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.119	5.17E-12	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.118	6.05E-12	YDR110W	FOB1	hom	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.118	6.60E-12	YEL012W	UBC8	hom	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
0.117	9.15E-12	YMR210W	YMR210W	hom	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification