YPL067C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL067C / YPL067C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.17|P-value:5.20E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.75|P-value:6.47E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.15|P-value:6.78E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.52|P-value:1.70E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.19|P-value:5.69E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.92|P-value:2.55E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:3.59|P-value:1.05E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.18|P-value:6.04E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.28|P-value:3.48E-4 ID:SGTC_441|Compound:propafenone|FD-Score:2.99|P-value:9.83E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.81|P-value:1.04E-9 ID:SGTC_551|Compound:k048-0028|FD-Score:4.55|P-value:1.35E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.56|P-value:1.44E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.34|P-value:2.74E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.78|P-value:4.69E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.40|P-value:2.20E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.42|P-value:2.46E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.50|P-value:2.14E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.33|P-value:2.86E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.86|P-value:3.33E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.29|P-value:6.03E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.26|P-value:4.41E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.68|P-value:6.92E-7 ID:SGTC_1914|Compound:st062367|FD-Score:4.29|P-value:4.83E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-4.91|P-value:2.62E-7 ID:SGTC_2026|Compound:5148700|FD-Score:-3.29|P-value:4.07E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.30|P-value:3.92E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.16|P-value:5.35E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.73|P-value:7.12E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.71|P-value:7.90E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.29|P-value:3.94E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.52|P-value:1.63E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.13|P-value:5.96E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.31|P-value:3.10E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.04|P-value:8.30E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.17|P-value:5.20E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.75|P-value:6.47E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.15|P-value:6.78E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.52|P-value:1.70E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.19|P-value:5.69E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.92|P-value:2.55E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:3.59|P-value:1.05E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.18|P-value:6.04E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.28|P-value:3.48E-4 ID:SGTC_441|Compound:propafenone|FD-Score:2.99|P-value:9.83E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.81|P-value:1.04E-9 ID:SGTC_551|Compound:k048-0028|FD-Score:4.55|P-value:1.35E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.56|P-value:1.44E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.34|P-value:2.74E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.78|P-value:4.69E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.40|P-value:2.20E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.42|P-value:2.46E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.50|P-value:2.14E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.33|P-value:2.86E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.86|P-value:3.33E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.29|P-value:6.03E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.26|P-value:4.41E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.68|P-value:6.92E-7 ID:SGTC_1914|Compound:st062367|FD-Score:4.29|P-value:4.83E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-4.91|P-value:2.62E-7 ID:SGTC_2026|Compound:5148700|FD-Score:-3.29|P-value:4.07E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.30|P-value:3.92E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.16|P-value:5.35E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.73|P-value:7.12E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.71|P-value:7.90E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.29|P-value:3.94E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.52|P-value:1.63E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.13|P-value:5.96E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.31|P-value:3.10E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.04|P-value:8.30E-4

Top fitness defect scores for YPL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 5.81 10.0 µM 1.04E-9 58 3.06E-9
2 SGTC_1908 st060353 4.68 56.5 µM 6.92E-7 RPP1 & pyrimidine depletion 24 1.44E-6
3 SGTC_2989 9073649 4.57 71.4 µM 1.18E-6 19 2.40E-6
4 SGTC_551 k048-0028 4.55 34.9 µM 1.35E-6 5 2.72E-6
5 SGTC_1914 st062367 4.29 72.6 µM 4.83E-6 17 9.08E-6
6 SGTC_278 4092-0821 3.92 23.9 µM 2.55E-5 plasma membrane duress 43 4.39E-5
7 SGTC_1270 0831-1170 3.86 17.3 µM 3.33E-5 11 5.65E-5
8 SGTC_722 3534-0461 3.78 190.0 µM 4.69E-5 PDR1 41 7.81E-5
9 SGTC_725 1497-0963 3.59 19.0 µM 1.02E-4 copper-dependent oxidative stress 28 1.63E-4
10 SGTC_291 4130-1278 3.59 35.5 µM 1.05E-4 Golgi 24 1.67E-4
11 SGTC_2167 5876490 3.42 200.0 µM 2.05E-4 52 3.15E-4
12 SGTC_730 1436-0052 3.40 41.2 µM 2.20E-4 mitochondrial processes 24 3.38E-4
13 SGTC_563 tetrahydrosecaminediol 3.34 614.0 µM 2.74E-4 amide catabolism 27 4.15E-4
14 SGTC_1258 0671-0043 3.33 57.1 µM 2.86E-4 50 4.32E-4
15 SGTC_3230 9131665 3.31 49.5 µM 3.10E-4 3 4.67E-4
16 SGTC_387 norethindrone acetate 3.28 66.7 µM 3.48E-4 39 5.20E-4
17 SGTC_1731 st035964 3.23 63.0 µM 4.16E-4 60 6.16E-4
18 SGTC_65 0798-0905 3.17 35.0 µM 5.20E-4 calcium & mitochondrial duress 143 7.61E-4
19 SGTC_2037 5169046 3.16 200.0 µM 5.35E-4 60S ribosome export 32 7.81E-4
20 SGTC_3153 9100258 3.13 49.5 µM 5.96E-4 63 8.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.90E-24 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.161 7.97E-21 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.160 8.93E-21 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.159 1.94E-20 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.154 3.15E-19 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 7.06E-18 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.141 2.30E-16 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.140 3.96E-16 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.140 4.42E-16 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.128 1.06E-13 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.120 2.62E-12 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.119 5.17E-12 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.118 6.05E-12 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.118 6.60E-12 YEL012W UBC8 hom Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
0.117 9.15E-12 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification