HIPHOP chemogenomics database

YPL074W / YTA6

Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL074W / YTA6

Click on Significant Values for Screen Details

Top fitness defect scores for YPL074W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2340	7987427	7.11	183.4 µM	3.46E-17		3	5.96E-13
2	SGTC_234	nsc-17383	6.22	10.7 µM	1.27E-13	ERG2	10	2.44E-10
3	SGTC_2479	5617353	6.17	43.9 µM	1.96E-13		7	3.36E-10
4	SGTC_1254	0550-0035	5.66	264.0 µM	1.36E-11		4	7.53E-9
5	SGTC_757	1066-0008	5.24	322.0 µM	3.30E-10	Golgi	7	7.82E-8
6	SGTC_2068	5226020	4.96	147.0 µM	2.53E-9		12	3.48E-7
7	SGTC_1522	st012842	4.88	45.6 µM	4.36E-9	RNA pol III & RNase P/MRP	11	5.20E-7
8	SGTC_1968	st069590	4.76	43.6 µM	1.00E-8		7	9.58E-7
9	SGTC_1742	st038235	4.30	28.9 µM	1.95E-7	mitochondrial stress	103	8.47E-6
10	SGTC_2690	usnic acid	4.28	100.0 µM	2.16E-7		22	9.14E-6
11	SGTC_798	1287-0182	4.22	476.0 µM	3.22E-7		16	1.23E-5
12	SGTC_3305	9127027	4.10	53.8 µM	6.61E-7		13	2.08E-5
13	SGTC_1450	4112-4260	3.87	37.6 µM	2.41E-6	calcium & mitochondrial duress	30	5.39E-5
14	SGTC_2165	5727197	3.80	32.1 µM	3.66E-6		36	7.34E-5
15	SGTC_2415	st077333	3.71	57.7 µM	5.98E-6		60	1.05E-4
16	SGTC_3205	9113483	3.63	49.5 µM	8.88E-6		40	1.41E-4
17	SGTC_1045	1348-1485	3.56	165.0 µM	1.29E-5		50	1.86E-4
18	SGTC_402	epigallocatechin gallate	3.55	10.0 µM	1.34E-5		41	1.91E-4
19	SGTC_1956	st077085	3.46	54.0 µM	2.13E-5		33	2.69E-4
20	SGTC_2327	6189656	3.37	200.0 µM	3.31E-5		38	3.72E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.126	2.00E-13	YOL134C_d	YOL134C_d	het	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.123	7.94E-13	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.123	8.33E-13	YOR152C_p	YOR152C_p	hom	Putative protein of unknown function; YOR152C is not an essential gene
0.113	6.29E-11	YJR141W_p	YJR141W_p	het	Essential protein of unknown function
0.110	1.54E-10	YHR086W	NAM8	hom	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.110	1.72E-10	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.102	3.08E-9	YDL222C	FMP45	hom	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.100	7.58E-9	YIR004W	DJP1	hom	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.097	1.93E-8	YAL003W	EFB1	het	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
0.096	2.89E-8	YGR136W	LSB1	hom	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.094	5.68E-8	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.091	1.15E-7	YER001W	MNN1	hom	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.089	2.38E-7	YDL234C	GYP7	hom	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.088	3.36E-7	YJL144W	YJL144W	hom	Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.088	3.52E-7	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p