YPL077C_p

Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL077C / YPL077C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:9.23|P-value:4.03E-20 ID:SGTC_18|Compound:0111-0177|FD-Score:4.68|P-value:1.89E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:3.55|P-value:2.31E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.96|P-value:4.63E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.22|P-value:7.55E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.34|P-value:9.22E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.43|P-value:6.15E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.95|P-value:4.95E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.34|P-value:4.85E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.15|P-value:9.44E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.97|P-value:1.95E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.17|P-value:8.58E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.30|P-value:5.62E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.29|P-value:5.78E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.84|P-value:7.49E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.18|P-value:8.62E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.82|P-value:8.27E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.31|P-value:2.73E-13 ID:SGTC_644|Compound:1498-1197|FD-Score:4.13|P-value:2.31E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:4.05|P-value:3.19E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.92|P-value:5.28E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.23|P-value:7.19E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.07|P-value:2.98E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.12|P-value:2.39E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.71|P-value:1.27E-4 ID:SGTC_1685|Compound:st024049|FD-Score:4.02|P-value:3.61E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.21|P-value:7.59E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.34|P-value:4.82E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.19|P-value:8.20E-4 ID:SGTC_1750|Compound:st081859|FD-Score:15.60|P-value:5.33E-54 ID:SGTC_1812|Compound:st052057|FD-Score:-3.49|P-value:2.79E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.78|P-value:9.76E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.95|P-value:4.98E-7 ID:SGTC_2244|Compound:6635614|FD-Score:-4.66|P-value:2.08E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.90|P-value:5.78E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.26|P-value:6.54E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.56|P-value:2.16E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.95|P-value:4.68E-5 ID:SGTC_2523|Compound:spermine|FD-Score:4.01|P-value:3.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.89|P-value:6.07E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:5.04E-5 ID:SGTC_2694|Compound:st077685|FD-Score:4.51|P-value:4.21E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-3.66|P-value:1.49E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.41|P-value:6.59E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.68|P-value:1.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.38|P-value:4.24E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.54|P-value:2.38E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:9.23|P-value:4.03E-20 ID:SGTC_18|Compound:0111-0177|FD-Score:4.68|P-value:1.89E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:3.55|P-value:2.31E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.96|P-value:4.63E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.22|P-value:7.55E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.34|P-value:9.22E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.43|P-value:6.15E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.95|P-value:4.95E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.34|P-value:4.85E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.15|P-value:9.44E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.97|P-value:1.95E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.17|P-value:8.58E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.30|P-value:5.62E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.29|P-value:5.78E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.84|P-value:7.49E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.18|P-value:8.62E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.82|P-value:8.27E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.31|P-value:2.73E-13 ID:SGTC_644|Compound:1498-1197|FD-Score:4.13|P-value:2.31E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:4.05|P-value:3.19E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.92|P-value:5.28E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.23|P-value:7.19E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.07|P-value:2.98E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.12|P-value:2.39E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.71|P-value:1.27E-4 ID:SGTC_1685|Compound:st024049|FD-Score:4.02|P-value:3.61E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.21|P-value:7.59E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.34|P-value:4.82E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.19|P-value:8.20E-4 ID:SGTC_1750|Compound:st081859|FD-Score:15.60|P-value:5.33E-54 ID:SGTC_1812|Compound:st052057|FD-Score:-3.49|P-value:2.79E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.78|P-value:9.76E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.95|P-value:4.98E-7 ID:SGTC_2244|Compound:6635614|FD-Score:-4.66|P-value:2.08E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.90|P-value:5.78E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.26|P-value:6.54E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.56|P-value:2.16E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.95|P-value:4.68E-5 ID:SGTC_2523|Compound:spermine|FD-Score:4.01|P-value:3.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.89|P-value:6.07E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:5.04E-5 ID:SGTC_2694|Compound:st077685|FD-Score:4.51|P-value:4.21E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-3.66|P-value:1.49E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.41|P-value:6.59E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.68|P-value:1.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.38|P-value:4.24E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.54|P-value:2.38E-4

Top fitness defect scores for YPL077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 15.60 2.4 µM 5.33E-54 endomembrane recycling 19 2.35E-55
2 SGTC_8 0354-0001 9.23 70.0 µM 4.03E-20 6 1.33E-20
3 SGTC_568 1193-0097 7.31 7.5 µM 2.73E-13 ERAD & cell cycle 43 1.35E-13
4 SGTC_87 0100-0052 5.97 35.5 µM 1.95E-9 32 1.21E-9
5 SGTC_18 0111-0177 4.68 500.0 nM 1.89E-6 42 1.40E-6
6 SGTC_2694 st077685 4.51 81.9 µM 4.21E-6 endomembrane recycling 18 3.18E-6
7 SGTC_64 000l-0018 4.43 272.1 µM 6.15E-6 ubiquinone biosynthesis & proteasome 125 4.69E-6
8 SGTC_59 0330-0160 4.34 1.3 µM 9.22E-6 91 7.11E-6
9 SGTC_644 1498-1197 4.13 63.3 µM 2.31E-5 15 1.82E-5
10 SGTC_1406 3909-7906 4.12 11.9 µM 2.39E-5 60S ribosome export 7 1.89E-5
11 SGTC_1048 3161-0300 4.07 24.5 µM 2.98E-5 20 2.36E-5
12 SGTC_675 1309-0189 4.05 238.0 µM 3.19E-5 11 2.54E-5
13 SGTC_1685 st024049 4.02 53.1 µM 3.61E-5 TSC3-RPN4 13 2.88E-5
14 SGTC_2523 spermine 4.01 47.7 µM 3.84E-5 calcium & mitochondrial duress 28 3.07E-5
15 SGTC_46 0329-0187a 3.96 2.2 µM 4.63E-5 74 3.72E-5
16 SGTC_71 0417-1750 3.95 47.8 µM 4.95E-5 Golgi 45 3.98E-5
17 SGTC_2688 kanamycin b 3.94 96.7 µM 5.04E-5 calcium & mitochondrial duress 366 4.06E-5
18 SGTC_343 4130-2827 3.84 29.8 µM 7.49E-5 36 6.09E-5
19 SGTC_562 3772-2733 3.82 112.0 µM 8.27E-5 ERG2 85 6.74E-5
20 SGTC_1966 st070145 3.78 16.1 µM 9.76E-5 27 7.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.561 2.31E-277 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.519 6.48E-231 YPR153W YPR153W hom Putative protein of unknown function
0.403 4.88E-131 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.388 8.41E-121 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.302 5.98E-72 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.281 6.37E-62 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.276 1.71E-59 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.262 9.49E-54 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1
0.246 2.77E-47 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.243 2.58E-46 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.230 2.41E-41 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.227 3.02E-40 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.218 1.73E-37 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.212 1.61E-35 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.209 1.61E-34 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion