HIPHOP chemogenomics database

YPL086C / ELP3

Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL086C / ELP3

Click on Significant Values for Screen Details

Top fitness defect scores for YPL086C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2963	9082507	9.11	9.0 µM	1.17E-16		1	4.02E-20
2	SGTC_577	r071-0003	6.46	38.6 µM	2.75E-9	fatty acid desaturase (OLE1)	12	5.15E-11
3	SGTC_2679	rapamycin	6.31	1.0 nM	6.32E-9		69	1.44E-10
4	SGTC_1844	rapamycin	6.20	4.0 nM	1.09E-8		85	2.82E-10
5	SGTC_2630	antimycin a	6.03	100.0 µM	2.62E-8	mitochondrial processes	11	8.29E-10
6	SGTC_1213	1315-0166	5.75	115.0 µM	1.01E-7		11	4.36E-9
7	SGTC_708	3448-5400	5.32	146.0 µM	7.60E-7		13	5.20E-8
8	SGTC_1506	4226-2149	5.30	212.0 µM	8.24E-7		10	5.75E-8
9	SGTC_685	1278-0033	5.30	54.9 µM	8.34E-7	60S ribosome export	4	5.83E-8
10	SGTC_1274	0865-0114	5.15	173.0 µM	1.58E-6		7	1.28E-7
11	SGTC_37	0566-0070	4.96	1.6 µM	3.68E-6		12	3.61E-7
12	SGTC_2954	9074818	4.90	52.7 µM	4.60E-6		21	4.74E-7
13	SGTC_1380	2291-0730	4.79	164.0 µM	7.22E-6		10	8.24E-7
14	SGTC_701	4424-0219	4.77	185.0 µM	7.84E-6	calcium & mitochondrial duress	10	9.11E-7
15	SGTC_2538	3',7'-epoxycaryophyllan-6-one	4.75	100.0 µM	8.52E-6		13	1.01E-6
16	SGTC_3181	9108277	4.57	49.5 µM	1.76E-5	iron homeostasis	6	2.45E-6
17	SGTC_983	1491-0821	4.43	12.2 µM	3.00E-5		7	4.71E-6
18	SGTC_1268	0828-0275	4.32	2.5 µM	4.59E-5		16	7.91E-6
19	SGTC_785	1270-0111	4.31	65.3 µM	4.66E-5		17	8.07E-6
20	SGTC_3052	9092717	4.19	49.5 µM	7.30E-5		17	1.40E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.187	8.32E-28	YHR187W	IKI1	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.173	5.42E-24	YGR200C	ELP2	hom	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.170	3.26E-23	YKL203C	TOR2	het	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.145	3.59E-17	YGL211W	NCS6	hom	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.143	8.04E-17	YJR066W	TOR1	hom	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.142	1.25E-16	YLR114C	AVL9	hom	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.140	4.76E-16	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.136	3.06E-15	YLR384C	IKI3	hom	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.132	2.13E-14	YNL119W	NCS2	hom	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.122	1.43E-12	YOR184W	SER1	hom	3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.120	2.76E-12	YHR186C	KOG1	het	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.120	3.64E-12	YOR069W	VPS5	hom	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
0.118	5.77E-12	YHR111W	UBA4	hom	Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.118	6.10E-12	YAL020C	ATS1	hom	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
0.113	5.89E-11	YBL071W-A	KTI11	hom	Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs