YPL090C / RPS6A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL090C / RPS6A

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.83|P-value:7.97E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:4.58|P-value:3.08E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.35|P-value:4.61E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.54|P-value:2.35E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.32|P-value:5.28E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:5.54|P-value:2.29E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.20|P-value:7.94E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.38|P-value:4.26E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.42|P-value:6.44E-6 ID:SGTC_728|Compound:3030-5151|FD-Score:6.35|P-value:1.79E-10 ID:SGTC_729|Compound:4092-0585|FD-Score:6.11|P-value:8.21E-10 ID:SGTC_731|Compound:3966-0296|FD-Score:3.30|P-value:5.65E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.17|P-value:8.52E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.91|P-value:5.59E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:3.37|P-value:4.38E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:6.04|P-value:1.26E-9 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.34|P-value:4.85E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.49|P-value:2.85E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:6.35|P-value:1.84E-10 ID:SGTC_938|Compound:3126-1755|FD-Score:5.74|P-value:7.42E-9 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.17|P-value:8.79E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.39|P-value:4.16E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:7.23|P-value:4.57E-13 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.18|P-value:8.40E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.50|P-value:2.74E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.22|P-value:7.53E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.46|P-value:5.30E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.49|P-value:4.75E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.04|P-value:3.29E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.94|P-value:5.01E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.39|P-value:4.18E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.14|P-value:1.97E-7 ID:SGTC_2128|Compound:5255449|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.44|P-value:3.35E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.54|P-value:2.40E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.15|P-value:2.00E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-4.10|P-value:2.54E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-4.19|P-value:1.68E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.77|P-value:1.00E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.50|P-value:2.76E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.43|P-value:6.04E-6 ID:SGTC_2450|Compound:5739737|FD-Score:6.59|P-value:3.93E-11 ID:SGTC_2467|Compound:5474540|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.19|P-value:8.27E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.31|P-value:5.29E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.07|P-value:3.00E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:4.34|P-value:9.06E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.33|P-value:5.03E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.82|P-value:8.12E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.75|P-value:1.07E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.26|P-value:6.57E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.51|P-value:4.33E-6 ID:SGTC_3030|Compound:9087619|FD-Score:3.80|P-value:8.96E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.71|P-value:1.23E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.47|P-value:3.08E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.55|P-value:2.32E-4 ID:SGTC_3075|Compound:9116269|FD-Score:8.26|P-value:1.77E-16 ID:SGTC_3080|Compound:9117754|FD-Score:-3.50|P-value:2.68E-4 ID:SGTC_3087|Compound:9117406|FD-Score:8.27|P-value:1.61E-16 ID:SGTC_3132|Compound:9126706|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.53|P-value:2.51E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-5.04|P-value:3.15E-7 ID:SGTC_3217|Compound:9129673|FD-Score:4.13|P-value:2.26E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.55|P-value:2.34E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.83|P-value:7.97E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:4.58|P-value:3.08E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.35|P-value:4.61E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.54|P-value:2.35E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.32|P-value:5.28E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:5.54|P-value:2.29E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.20|P-value:7.94E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.38|P-value:4.26E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.42|P-value:6.44E-6 ID:SGTC_728|Compound:3030-5151|FD-Score:6.35|P-value:1.79E-10 ID:SGTC_729|Compound:4092-0585|FD-Score:6.11|P-value:8.21E-10 ID:SGTC_731|Compound:3966-0296|FD-Score:3.30|P-value:5.65E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.17|P-value:8.52E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.91|P-value:5.59E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:3.37|P-value:4.38E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:6.04|P-value:1.26E-9 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.34|P-value:4.85E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.49|P-value:2.85E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:6.35|P-value:1.84E-10 ID:SGTC_938|Compound:3126-1755|FD-Score:5.74|P-value:7.42E-9 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.17|P-value:8.79E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.39|P-value:4.16E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:7.23|P-value:4.57E-13 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.18|P-value:8.40E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.50|P-value:2.74E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.22|P-value:7.53E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.46|P-value:5.30E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.49|P-value:4.75E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.04|P-value:3.29E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.94|P-value:5.01E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.39|P-value:4.18E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.14|P-value:1.97E-7 ID:SGTC_2128|Compound:5255449|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.44|P-value:3.35E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.54|P-value:2.40E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.15|P-value:2.00E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-4.10|P-value:2.54E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-4.19|P-value:1.68E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.77|P-value:1.00E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.50|P-value:2.76E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.43|P-value:6.04E-6 ID:SGTC_2450|Compound:5739737|FD-Score:6.59|P-value:3.93E-11 ID:SGTC_2467|Compound:5474540|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.19|P-value:8.27E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.31|P-value:5.29E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.07|P-value:3.00E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:4.34|P-value:9.06E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.33|P-value:5.03E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.82|P-value:8.12E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.75|P-value:1.07E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.26|P-value:6.57E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.51|P-value:4.33E-6 ID:SGTC_3030|Compound:9087619|FD-Score:3.80|P-value:8.96E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.71|P-value:1.23E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.47|P-value:3.08E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.55|P-value:2.32E-4 ID:SGTC_3075|Compound:9116269|FD-Score:8.26|P-value:1.77E-16 ID:SGTC_3080|Compound:9117754|FD-Score:-3.50|P-value:2.68E-4 ID:SGTC_3087|Compound:9117406|FD-Score:8.27|P-value:1.61E-16 ID:SGTC_3132|Compound:9126706|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.53|P-value:2.51E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-5.04|P-value:3.15E-7 ID:SGTC_3217|Compound:9129673|FD-Score:4.13|P-value:2.26E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.55|P-value:2.34E-4

Top fitness defect scores for YPL090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3087 9117406 8.27 49.5 µM 1.61E-16 1 6.79E-17
2 SGTC_3075 9116269 8.26 49.5 µM 1.77E-16 2 7.48E-17
3 SGTC_1129 3453-1384 7.23 223.0 µM 4.57E-13 5 2.34E-13
4 SGTC_2450 5739737 6.59 12.9 µM 3.93E-11 2 2.25E-11
5 SGTC_728 3030-5151 6.35 22.5 µM 1.79E-10 1 1.06E-10
6 SGTC_937 3122-0005 6.35 46.7 µM 1.84E-10 4 1.09E-10
7 SGTC_729 4092-0585 6.11 94.1 µM 8.21E-10 3 5.06E-10
8 SGTC_932 2857-0803 6.04 154.0 µM 1.26E-9 7 7.82E-10
9 SGTC_938 3126-1755 5.74 342.0 µM 7.42E-9 2 4.83E-9
10 SGTC_270 tamoxifen 5.54 5.5 µM 2.29E-8 NEO1 9 1.53E-8
11 SGTC_1839 st053978 5.14 48.0 µM 1.97E-7 6 1.39E-7
12 SGTC_31 0508-1974 4.58 57.2 µM 3.08E-6 13 2.32E-6
13 SGTC_2967 9089538 4.51 49.9 µM 4.33E-6 19 3.29E-6
14 SGTC_1374 2889-5571 4.49 141.0 µM 4.75E-6 RSC complex & mRNA processing 24 3.62E-6
15 SGTC_1280 0880-0253 4.46 10.1 µM 5.30E-6 7 4.05E-6
16 SGTC_2447 5741742 4.43 33.8 µM 6.04E-6 12 4.64E-6
17 SGTC_723 4182-0001 4.42 115.0 µM 6.44E-6 20 4.95E-6
18 SGTC_2669 eugenol 4.34 100.0 µM 9.06E-6 8 7.02E-6
19 SGTC_3217 9129673 4.13 49.5 µM 2.26E-5 35 1.79E-5
20 SGTC_2603 homopterocarpin 4.07 100.0 µM 3.00E-5 33 2.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.39E-20 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.108 3.37E-10 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 7.68E-9 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.086 6.95E-7 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.082 1.77E-6 YNL321W VNX1 hom Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate
0.078 5.48E-6 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.077 8.55E-6 YBR293W VBA2 hom Permease of basic amino acids in the vacuolar membrane
0.075 1.49E-5 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.073 2.11E-5 YPL273W SAM4 hom S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.073 2.37E-5 YBR030W RKM3 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein
0.073 2.53E-5 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.072 2.68E-5 YHR034C PIH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.071 3.54E-5 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.070 4.48E-5 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.068 8.09E-5 YER088C DOT6 hom Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress