YPL091W / GLR1

Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL091W / GLR1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.80|P-value:1.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.82|P-value:3.61E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:5.20|P-value:6.47E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:12.30|P-value:9.54E-31 ID:SGTC_251|Compound:melphalan|FD-Score:3.75|P-value:2.41E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.38|P-value:2.25E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.49|P-value:5.64E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.51|P-value:5.32E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.40|P-value:7.57E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:8.48|P-value:1.55E-15 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.91|P-value:1.52E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.32|P-value:9.70E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.37|P-value:8.39E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.00|P-value:9.77E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:16.20|P-value:1.42E-51 ID:SGTC_935|Compound:2996-0153|FD-Score:3.41|P-value:7.36E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.40|P-value:8.49E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-4.02|P-value:1.02E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.44|P-value:1.99E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:4.24|P-value:3.89E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.09|P-value:6.95E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:6.24|P-value:3.21E-9 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.36|P-value:2.48E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.44|P-value:1.80E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.62|P-value:3.75E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.35|P-value:2.52E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.97|P-value:1.07E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.75|P-value:2.63E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.42|P-value:7.22E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.05|P-value:8.05E-5 ID:SGTC_1713|Compound:st033146|FD-Score:5.97|P-value:1.38E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:4.02|P-value:8.90E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.33|P-value:9.57E-4 ID:SGTC_1825|Compound:st052143|FD-Score:4.22|P-value:4.29E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.97|P-value:1.10E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.47|P-value:1.58E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-3.47|P-value:6.66E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.73|P-value:5.36E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.67|P-value:3.14E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.15|P-value:5.50E-5 ID:SGTC_2302|Compound:7771753|FD-Score:7.01|P-value:3.56E-11 ID:SGTC_2320|Compound:7373003|FD-Score:4.07|P-value:7.58E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.53|P-value:1.22E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-4.90|P-value:2.90E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-4.32|P-value:3.23E-5 ID:SGTC_2390|Compound:9097792|FD-Score:3.41|P-value:7.43E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:9.36|P-value:1.65E-18 ID:SGTC_2462|Compound:5162487|FD-Score:4.10|P-value:6.82E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.45|P-value:1.72E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.28|P-value:3.38E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.75|P-value:2.42E-4 ID:SGTC_2703|Compound:st077852|FD-Score:5.06|P-value:1.25E-6 ID:SGTC_2709|Compound:st078560|FD-Score:-3.44|P-value:7.32E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.34|P-value:2.69E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.38|P-value:2.29E-5 ID:SGTC_2797|Compound:7859098|FD-Score:7.64|P-value:5.97E-13 ID:SGTC_2814|Compound:7977482|FD-Score:-4.56|P-value:1.24E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.46|P-value:6.40E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.62|P-value:3.68E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.46|P-value:6.40E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.06|P-value:7.80E-5 ID:SGTC_3017|Compound:9080681|FD-Score:4.74|P-value:5.08E-6 ID:SGTC_3049|Compound:9092223|FD-Score:-4.61|P-value:1.01E-5 ID:SGTC_3052|Compound:9092717|FD-Score:6.09|P-value:7.17E-9 ID:SGTC_3058|Compound:9093861|FD-Score:4.11|P-value:6.44E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.56|P-value:4.53E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.46|P-value:6.28E-4 ID:SGTC_3189|Compound:9110682|FD-Score:6.56|P-value:5.30E-10 ID:SGTC_3193|Compound:9111931|FD-Score:3.93|P-value:1.25E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.58|P-value:4.31E-4 ID:SGTC_3267|Compound:9137951|FD-Score:4.32|P-value:2.87E-5 ID:SGTC_3301|Compound:9125354|FD-Score:4.04|P-value:8.35E-5 ID:SGTC_3306|Compound:9127676|FD-Score:3.64|P-value:3.46E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.52|P-value:5.18E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.80|P-value:1.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.82|P-value:3.61E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:5.20|P-value:6.47E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:12.30|P-value:9.54E-31 ID:SGTC_251|Compound:melphalan|FD-Score:3.75|P-value:2.41E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.38|P-value:2.25E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.49|P-value:5.64E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.51|P-value:5.32E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.40|P-value:7.57E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:8.48|P-value:1.55E-15 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.91|P-value:1.52E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.32|P-value:9.70E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.37|P-value:8.39E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.00|P-value:9.77E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:16.20|P-value:1.42E-51 ID:SGTC_935|Compound:2996-0153|FD-Score:3.41|P-value:7.36E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.40|P-value:8.49E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-4.02|P-value:1.02E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.44|P-value:1.99E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:4.24|P-value:3.89E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.09|P-value:6.95E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:6.24|P-value:3.21E-9 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.36|P-value:2.48E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.44|P-value:1.80E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.62|P-value:3.75E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.35|P-value:2.52E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.97|P-value:1.07E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.75|P-value:2.63E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.42|P-value:7.22E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.05|P-value:8.05E-5 ID:SGTC_1713|Compound:st033146|FD-Score:5.97|P-value:1.38E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:4.02|P-value:8.90E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.33|P-value:9.57E-4 ID:SGTC_1825|Compound:st052143|FD-Score:4.22|P-value:4.29E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.97|P-value:1.10E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.47|P-value:1.58E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-3.47|P-value:6.66E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.73|P-value:5.36E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.67|P-value:3.14E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.15|P-value:5.50E-5 ID:SGTC_2302|Compound:7771753|FD-Score:7.01|P-value:3.56E-11 ID:SGTC_2320|Compound:7373003|FD-Score:4.07|P-value:7.58E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.53|P-value:1.22E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-4.90|P-value:2.90E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-4.32|P-value:3.23E-5 ID:SGTC_2390|Compound:9097792|FD-Score:3.41|P-value:7.43E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:9.36|P-value:1.65E-18 ID:SGTC_2462|Compound:5162487|FD-Score:4.10|P-value:6.82E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.45|P-value:1.72E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.28|P-value:3.38E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.75|P-value:2.42E-4 ID:SGTC_2703|Compound:st077852|FD-Score:5.06|P-value:1.25E-6 ID:SGTC_2709|Compound:st078560|FD-Score:-3.44|P-value:7.32E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.34|P-value:2.69E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.38|P-value:2.29E-5 ID:SGTC_2797|Compound:7859098|FD-Score:7.64|P-value:5.97E-13 ID:SGTC_2814|Compound:7977482|FD-Score:-4.56|P-value:1.24E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.46|P-value:6.40E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.62|P-value:3.68E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.46|P-value:6.40E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.06|P-value:7.80E-5 ID:SGTC_3017|Compound:9080681|FD-Score:4.74|P-value:5.08E-6 ID:SGTC_3049|Compound:9092223|FD-Score:-4.61|P-value:1.01E-5 ID:SGTC_3052|Compound:9092717|FD-Score:6.09|P-value:7.17E-9 ID:SGTC_3058|Compound:9093861|FD-Score:4.11|P-value:6.44E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.56|P-value:4.53E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.46|P-value:6.28E-4 ID:SGTC_3189|Compound:9110682|FD-Score:6.56|P-value:5.30E-10 ID:SGTC_3193|Compound:9111931|FD-Score:3.93|P-value:1.25E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.58|P-value:4.31E-4 ID:SGTC_3267|Compound:9137951|FD-Score:4.32|P-value:2.87E-5 ID:SGTC_3301|Compound:9125354|FD-Score:4.04|P-value:8.35E-5 ID:SGTC_3306|Compound:9127676|FD-Score:3.64|P-value:3.46E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.52|P-value:5.18E-4

Top fitness defect scores for YPL091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_842 0271-0008 16.20 11.1 µM 1.42E-51 heme biosynthesis & mitochondrial translocase 2 2.00E-59
2 SGTC_184 1494-0393 12.30 24.7 µM 9.54E-31 4 2.71E-35
3 SGTC_2405 ticlatone 9.36 3.5 µM 1.65E-18 11 4.01E-21
4 SGTC_695 3505-6186 8.48 243.0 µM 1.55E-15 1 1.10E-17
5 SGTC_2797 7859098 7.64 81.8 µM 5.97E-13 1 1.07E-14
6 SGTC_2302 7771753 7.01 200.0 µM 3.56E-11 3 1.21E-12
7 SGTC_3189 9110682 6.56 49.5 µM 5.30E-10 6 2.73E-11
8 SGTC_1150 3909-7983 6.24 10.9 µM 3.21E-9 2 2.19E-10
9 SGTC_3052 9092717 6.09 49.5 µM 7.17E-9 3 5.52E-10
10 SGTC_1713 st033146 5.97 12.8 µM 1.38E-8 3 1.17E-9
11 SGTC_154 3389-1638 5.20 511.1 µM 6.47E-7 6 9.90E-8
12 SGTC_2703 st077852 5.06 53.4 µM 1.25E-6 5 2.12E-7
13 SGTC_145 3737-0113 4.82 38.4 µM 3.61E-6 DNA intercalators 49 7.17E-7
14 SGTC_3017 9080681 4.74 49.5 µM 5.08E-6 7 1.06E-6
15 SGTC_2009 4012297 4.73 12.1 µM 5.36E-6 cell wall signaling 43 1.13E-6
16 SGTC_2323 6148992 4.53 148.3 µM 1.22E-5 20 2.90E-6
17 SGTC_1993 st073995 4.47 70.8 µM 1.58E-5 13 3.92E-6
18 SGTC_2562 3',7'-dimethoxyflavone 4.45 64.9 µM 1.72E-5 18 4.32E-6
19 SGTC_1275 0867-0008 4.44 21.1 µM 1.80E-5 8 4.56E-6
20 SGTC_273 hydroxyurea 4.38 18.1 mM 2.25E-5 heme biosynthesis & mitochondrial translocase 26 5.88E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 3.18E-26 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.173 7.27E-24 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.143 6.55E-17 YDR126W SWF1 hom Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
0.125 3.94E-13 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.117 8.99E-12 YMR001C-A_p YMR001C-A_p hom Putative protein of unknown function
0.114 3.25E-11 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.114 3.24E-11 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.112 7.21E-11 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.105 9.25E-10 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.103 2.32E-9 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.102 3.06E-9 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.101 4.54E-9 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.099 8.28E-9 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.098 1.14E-8 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.093 6.11E-8 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing