Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPL096W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.115 | 2.87E-11 | YIL056W | VHR1 | hom | Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication |
0.114 | 3.06E-11 | YJL200C | ACO2 | hom | Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol |
0.109 | 2.76E-10 | YEL023C_p | YEL023C_p | hom | Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene |
0.107 | 5.10E-10 | YDL001W | RMD1 | hom | Cytoplasmic protein required for sporulation |
0.106 | 7.76E-10 | YER076C_p | YER076C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization |
0.097 | 1.81E-8 | YOR214C_p | YOR214C_p | hom | Putative protein of unknown function; YOR214C is not an essential gene |
0.095 | 3.17E-8 | YBR186W | PCH2 | hom | Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation |
0.092 | 9.40E-8 | YIL044C | AGE2 | hom | ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif |
0.091 | 1.30E-7 | YNL038W | GPI15 | het | Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein |
0.090 | 1.63E-7 | YOR025W | HST3 | hom | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
0.090 | 1.71E-7 | YGR283C | YGR283C | hom | Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus |
0.085 | 8.50E-7 | YJR045C | SSC1 | het | Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication |
0.084 | 1.09E-6 | YNL218W | MGS1 | hom | Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress |
0.083 | 1.64E-6 | YJL103C | GSM1 | hom | Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis |
0.082 | 2.01E-6 | YPL255W | BBP1 | het | Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p |