YPL097W / MSY1

Mitochondrial tyrosyl-tRNA synthetase

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL097W / MSY1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.16|P-value:2.94E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.49|P-value:3.77E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.26|P-value:7.35E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.51|P-value:3.52E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.51|P-value:3.08E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.58|P-value:2.76E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.02|P-value:5.14E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.26|P-value:1.79E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.18|P-value:1.14E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:4.20|P-value:2.43E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:4.58|P-value:4.83E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.79|P-value:1.09E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.26|P-value:8.20E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-4.00|P-value:4.73E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.32|P-value:6.77E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.77|P-value:1.34E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.71|P-value:1.68E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.33|P-value:6.52E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.80|P-value:1.19E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.23|P-value:2.13E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:3.48|P-value:3.85E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.42|P-value:9.63E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.65|P-value:2.13E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.65|P-value:1.83E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.39|P-value:5.31E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.73|P-value:2.42E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.39|P-value:1.10E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.19|P-value:2.63E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.34|P-value:1.39E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:7.24|P-value:1.17E-12 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.70|P-value:1.54E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.79|P-value:1.08E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.01|P-value:5.27E-5 ID:SGTC_1627|Compound:st003713|FD-Score:9.19|P-value:2.74E-19 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:6.46|P-value:2.00E-10 ID:SGTC_1633|Compound:st005664|FD-Score:3.82|P-value:1.10E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.29|P-value:7.37E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.67|P-value:1.95E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.61|P-value:4.16E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.65|P-value:2.10E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.90|P-value:8.09E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.41|P-value:4.38E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.87|P-value:9.32E-5 ID:SGTC_2256|Compound:7954252|FD-Score:5.90|P-value:5.74E-9 ID:SGTC_2283|Compound:7944793|FD-Score:4.11|P-value:3.53E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.36|P-value:5.18E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.48|P-value:3.87E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.16|P-value:2.84E-5 ID:SGTC_2570|Compound:licareol|FD-Score:4.63|P-value:3.78E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.27|P-value:8.07E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.21|P-value:9.66E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.67|P-value:1.93E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.59|P-value:2.62E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.59|P-value:2.59E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-5.24|P-value:1.69E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.70|P-value:1.75E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-4.11|P-value:3.11E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-4.97|P-value:6.57E-7 ID:SGTC_2857|Compound:9024691|FD-Score:-3.68|P-value:1.67E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.63|P-value:3.26E-6 ID:SGTC_2885|Compound:9057732|FD-Score:-5.51|P-value:4.04E-8 ID:SGTC_2893|Compound:9048488|FD-Score:-4.39|P-value:9.41E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-10.60|P-value:4.32E-25 ID:SGTC_2960|Compound:9079389|FD-Score:4.88|P-value:1.18E-6 ID:SGTC_3031|Compound:9088762|FD-Score:3.49|P-value:3.76E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.59|P-value:2.27E-4 ID:SGTC_3124|Compound:9127567|FD-Score:5.43|P-value:7.30E-8 ID:SGTC_3126|Compound:9127922|FD-Score:12.10|P-value:7.67E-32 ID:SGTC_3138|Compound:9097216|FD-Score:3.25|P-value:8.46E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.30|P-value:7.10E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-4.06|P-value:3.79E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.16|P-value:2.94E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.49|P-value:3.77E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.26|P-value:7.35E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.51|P-value:3.52E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.51|P-value:3.08E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.58|P-value:2.76E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.02|P-value:5.14E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.26|P-value:1.79E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.18|P-value:1.14E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:4.20|P-value:2.43E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:4.58|P-value:4.83E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.79|P-value:1.09E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.26|P-value:8.20E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-4.00|P-value:4.73E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.32|P-value:6.77E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.77|P-value:1.34E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.71|P-value:1.68E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.33|P-value:6.52E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.80|P-value:1.19E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.23|P-value:2.13E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:3.48|P-value:3.85E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.42|P-value:9.63E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.65|P-value:2.13E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.65|P-value:1.83E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.39|P-value:5.31E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.73|P-value:2.42E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.39|P-value:1.10E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.19|P-value:2.63E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.34|P-value:1.39E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:7.24|P-value:1.17E-12 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.70|P-value:1.54E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.79|P-value:1.08E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.01|P-value:5.27E-5 ID:SGTC_1627|Compound:st003713|FD-Score:9.19|P-value:2.74E-19 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:6.46|P-value:2.00E-10 ID:SGTC_1633|Compound:st005664|FD-Score:3.82|P-value:1.10E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.29|P-value:7.37E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.67|P-value:1.95E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.61|P-value:4.16E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.65|P-value:2.10E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.90|P-value:8.09E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.41|P-value:4.38E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.87|P-value:9.32E-5 ID:SGTC_2256|Compound:7954252|FD-Score:5.90|P-value:5.74E-9 ID:SGTC_2283|Compound:7944793|FD-Score:4.11|P-value:3.53E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.36|P-value:5.18E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.48|P-value:3.87E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.16|P-value:2.84E-5 ID:SGTC_2570|Compound:licareol|FD-Score:4.63|P-value:3.78E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.27|P-value:8.07E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.21|P-value:9.66E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.67|P-value:1.93E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.59|P-value:2.62E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.59|P-value:2.59E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-5.24|P-value:1.69E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.70|P-value:1.75E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-4.11|P-value:3.11E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-4.97|P-value:6.57E-7 ID:SGTC_2857|Compound:9024691|FD-Score:-3.68|P-value:1.67E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.63|P-value:3.26E-6 ID:SGTC_2885|Compound:9057732|FD-Score:-5.51|P-value:4.04E-8 ID:SGTC_2893|Compound:9048488|FD-Score:-4.39|P-value:9.41E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-10.60|P-value:4.32E-25 ID:SGTC_2960|Compound:9079389|FD-Score:4.88|P-value:1.18E-6 ID:SGTC_3031|Compound:9088762|FD-Score:3.49|P-value:3.76E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.59|P-value:2.27E-4 ID:SGTC_3124|Compound:9127567|FD-Score:5.43|P-value:7.30E-8 ID:SGTC_3126|Compound:9127922|FD-Score:12.10|P-value:7.67E-32 ID:SGTC_3138|Compound:9097216|FD-Score:3.25|P-value:8.46E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.30|P-value:7.10E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-4.06|P-value:3.79E-5

Top fitness defect scores for YPL097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3126 9127922 12.10 49.5 µM 7.67E-32 fatty acid desaturase (OLE1) 5 9.18E-34
2 SGTC_1627 st003713 9.19 25.6 µM 2.74E-19 calcium & mitochondrial duress 8 1.99E-20
3 SGTC_1446 4239-0190 7.24 62.0 µM 1.17E-12 5 2.21E-13
4 SGTC_1631 benzylvanillin 6.46 81.9 µM 2.00E-10 Golgi 4 5.23E-11
5 SGTC_275 trichlorophene 6.18 5.7 µM 1.14E-9 mitochondrial stress 111 3.30E-10
6 SGTC_2256 7954252 5.90 200.0 µM 5.74E-9 mitochondrial processes 2 1.85E-9
7 SGTC_3124 9127567 5.43 49.5 µM 7.30E-8 DNA damage response 5 2.75E-8
8 SGTC_236 1509-0011 5.26 5.3 µM 1.79E-7 311 7.14E-8
9 SGTC_1353 1498-1206 5.19 8.1 µM 2.63E-7 mitochondrial response to ROS 26 1.07E-7
10 SGTC_2960 9079389 4.88 6.0 µM 1.18E-6 11 5.31E-7
11 SGTC_1333 1482-0047 4.73 286.0 µM 2.42E-6 9 1.14E-6
12 SGTC_2570 licareol 4.63 100.0 µM 3.78E-6 15 1.83E-6
13 SGTC_2012 4023501 4.61 200.0 µM 4.16E-6 20 2.02E-6
14 SGTC_522 1273-0010 4.58 11.6 µM 4.83E-6 60S ribosome export 13 2.37E-6
15 SGTC_1043 0916-0009 4.42 19.3 µM 9.63E-6 15 4.93E-6
16 SGTC_1339 1486-1321 4.39 22.7 µM 1.10E-5 ERG2 10 5.66E-6
17 SGTC_1362 1611-0397 4.34 101.0 µM 1.39E-5 12 7.28E-6
18 SGTC_972 1319-0219 4.23 195.0 µM 2.13E-5 17 1.14E-5
19 SGTC_310 1273-0058 4.20 1.1 µM 2.43E-5 mitochondrial stress 229 1.32E-5
20 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.16 54.6 µM 2.84E-5 RPP1 & pyrimidine depletion 26 1.56E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 1.34E-50 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.251 2.17E-49 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.243 3.44E-46 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.240 3.51E-45 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.237 4.25E-44 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.233 1.11E-42 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
0.232 3.50E-42 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.231 5.45E-42 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.227 1.55E-40 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.226 4.95E-40 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.224 1.77E-39 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.223 3.70E-39 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.222 1.35E-38 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.220 4.37E-38 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.219 1.15E-37 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly