YPL110C / GDE1

Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL110C / GDE1

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-2.99|P-value:9.43E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.28|P-value:6.78E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-3.87|P-value:3.06E-5 ID:SGTC_417|Compound:st075190|FD-Score:-3.24|P-value:3.85E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.38|P-value:2.26E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.82|P-value:5.14E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.12|P-value:7.78E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.29|P-value:4.30E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.11|P-value:6.23E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.08|P-value:6.89E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.46|P-value:2.26E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:6.37|P-value:4.02E-11 ID:SGTC_600|Compound:1495-0418|FD-Score:3.85|P-value:4.64E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:4.36|P-value:4.55E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:5.09|P-value:1.12E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:4.72|P-value:7.60E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.07|P-value:9.24E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.36|P-value:3.33E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.17|P-value:6.63E-4 ID:SGTC_1521|Compound:st012942|FD-Score:5.85|P-value:1.22E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.03|P-value:8.28E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.26|P-value:7.55E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.46|P-value:2.25E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.44|P-value:2.42E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.17|P-value:5.02E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.00|P-value:9.13E-4 ID:SGTC_2002|Compound:4023503|FD-Score:6.80|P-value:1.94E-12 ID:SGTC_2003|Compound:4023581|FD-Score:4.10|P-value:1.52E-5 ID:SGTC_2004|Compound:4023728|FD-Score:6.35|P-value:4.76E-11 ID:SGTC_2029|Compound:5175081|FD-Score:3.80|P-value:5.62E-5 ID:SGTC_2114|Compound:5491910|FD-Score:4.05|P-value:1.91E-5 ID:SGTC_2201|Compound:6605497|FD-Score:3.13|P-value:7.46E-4 ID:SGTC_2412|Compound:st077135|FD-Score:5.12|P-value:9.15E-8 ID:SGTC_2482|Compound:5981709|FD-Score:4.05|P-value:1.97E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.73|P-value:7.66E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.98|P-value:9.64E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.32|P-value:3.76E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.15|P-value:7.02E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.53|P-value:1.72E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.08|P-value:6.82E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.42|P-value:1.69E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.27|P-value:4.90E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.07|P-value:9.38E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.15|P-value:5.38E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.96|P-value:2.83E-5 ID:SGTC_3190|Compound:9110366|FD-Score:4.80|P-value:5.28E-7 ID:SGTC_3207|Compound:9114163|FD-Score:3.26|P-value:4.66E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.99|P-value:9.43E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.28|P-value:6.78E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-3.87|P-value:3.06E-5 ID:SGTC_417|Compound:st075190|FD-Score:-3.24|P-value:3.85E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.38|P-value:2.26E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.82|P-value:5.14E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.12|P-value:7.78E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.29|P-value:4.30E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.11|P-value:6.23E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.08|P-value:6.89E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.46|P-value:2.26E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:6.37|P-value:4.02E-11 ID:SGTC_600|Compound:1495-0418|FD-Score:3.85|P-value:4.64E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:4.36|P-value:4.55E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:5.09|P-value:1.12E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:4.72|P-value:7.60E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.07|P-value:9.24E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.36|P-value:3.33E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.17|P-value:6.63E-4 ID:SGTC_1521|Compound:st012942|FD-Score:5.85|P-value:1.22E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.03|P-value:8.28E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.26|P-value:7.55E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.46|P-value:2.25E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.44|P-value:2.42E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.17|P-value:5.02E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.00|P-value:9.13E-4 ID:SGTC_2002|Compound:4023503|FD-Score:6.80|P-value:1.94E-12 ID:SGTC_2003|Compound:4023581|FD-Score:4.10|P-value:1.52E-5 ID:SGTC_2004|Compound:4023728|FD-Score:6.35|P-value:4.76E-11 ID:SGTC_2029|Compound:5175081|FD-Score:3.80|P-value:5.62E-5 ID:SGTC_2114|Compound:5491910|FD-Score:4.05|P-value:1.91E-5 ID:SGTC_2201|Compound:6605497|FD-Score:3.13|P-value:7.46E-4 ID:SGTC_2412|Compound:st077135|FD-Score:5.12|P-value:9.15E-8 ID:SGTC_2482|Compound:5981709|FD-Score:4.05|P-value:1.97E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.73|P-value:7.66E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.98|P-value:9.64E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.32|P-value:3.76E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.15|P-value:7.02E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.53|P-value:1.72E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.08|P-value:6.82E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.42|P-value:1.69E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.27|P-value:4.90E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.07|P-value:9.38E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.15|P-value:5.38E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.96|P-value:2.83E-5 ID:SGTC_3190|Compound:9110366|FD-Score:4.80|P-value:5.28E-7 ID:SGTC_3207|Compound:9114163|FD-Score:3.26|P-value:4.66E-4

Top fitness defect scores for YPL110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2002 4023503 6.80 131.0 µM 1.94E-12 mitochondrial processes 5 5.10E-12
2 SGTC_534 k292-0788 6.37 63.4 µM 4.02E-11 mitochondrial processes 2 9.24E-11
3 SGTC_2004 4023728 6.35 41.9 µM 4.76E-11 6 1.09E-10
4 SGTC_1521 st012942 5.85 49.4 µM 1.22E-9 8 2.42E-9
5 SGTC_3020 9089140 5.42 49.5 µM 1.69E-8 6 3.00E-8
6 SGTC_2412 st077135 5.12 33.4 µM 9.15E-8 7 1.51E-7
7 SGTC_944 3370-0224 5.09 231.0 µM 1.12E-7 9 1.83E-7
8 SGTC_3190 9110366 4.80 49.5 µM 5.28E-7 6 8.12E-7
9 SGTC_978 1416-0512 4.72 87.4 µM 7.60E-7 redox potentiating 18 1.15E-6
10 SGTC_773 4358-1457 4.36 44.6 µM 4.55E-6 32 6.41E-6
11 SGTC_359 0081-0058 4.28 15.9 µM 6.78E-6 60S ribosome export 33 9.39E-6
12 SGTC_1570 verbenone 4.26 133.0 µM 7.55E-6 11 1.04E-5
13 SGTC_2003 4023581 4.10 200.0 µM 1.52E-5 cell wall signaling 31 2.04E-5
14 SGTC_2114 5491910 4.05 81.2 µM 1.91E-5 8 2.54E-5
15 SGTC_2482 5981709 4.05 142.7 µM 1.97E-5 PDR1 33 2.61E-5
16 SGTC_3189 9110682 3.96 49.5 µM 2.83E-5 36 3.71E-5
17 SGTC_600 1495-0418 3.85 41.6 µM 4.64E-5 RPP1 & pyrimidine depletion 11 5.96E-5
18 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.82 8.0 µM 5.14E-5 27 6.57E-5
19 SGTC_2029 5175081 3.80 200.0 µM 5.62E-5 21 7.16E-5
20 SGTC_2486 5283202 3.73 22.4 µM 7.66E-5 40 9.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.16E-14 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.123 8.62E-13 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.117 1.11E-11 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.115 2.25E-11 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.112 7.47E-11 YER128W VFA1 hom Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
0.107 4.70E-10 YPR154W PIN3 hom Protein that induces appearance of [PIN+] prion when overproduced
0.106 7.85E-10 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.098 1.51E-8 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.097 1.72E-8 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.095 3.23E-8 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.087 4.38E-7 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.086 5.71E-7 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.086 5.87E-7 YDR135C YCF1 hom Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR
0.086 6.28E-7 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.082 2.02E-6 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p