YPL113C_p

Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL113C / YPL113C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.39|P-value:1.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.42|P-value:8.52E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.05|P-value:6.51E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-3.55|P-value:8.92E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.09|P-value:5.50E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.17|P-value:2.84E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.26|P-value:1.99E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.31|P-value:1.56E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.05|P-value:6.61E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.51|P-value:6.96E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:2.99|P-value:5.70E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.08|P-value:4.00E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.38|P-value:1.81E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-8.83|P-value:2.51E-21 ID:SGTC_974|Compound:1326-0144|FD-Score:3.96|P-value:8.57E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.96|P-value:8.85E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.21|P-value:3.57E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-4.68|P-value:3.54E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.37|P-value:1.09E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.96|P-value:8.53E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.47|P-value:8.00E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:2.86|P-value:9.06E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:5.58|P-value:7.87E-10 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.57|P-value:3.62E-7 ID:SGTC_1571|Compound:st070080|FD-Score:3.72|P-value:2.70E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-3.35|P-value:2.05E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.67|P-value:3.41E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.57|P-value:5.37E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_1973|Compound:st070275|FD-Score:2.87|P-value:8.67E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.00|P-value:5.40E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.13|P-value:4.74E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.42|P-value:1.02E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-2.96|P-value:9.05E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_2302|Compound:7771753|FD-Score:2.88|P-value:8.47E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.07|P-value:6.07E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-4.00|P-value:1.15E-5 ID:SGTC_2813|Compound:7971799|FD-Score:5.11|P-value:1.60E-8 ID:SGTC_2933|Compound:9026794|FD-Score:3.36|P-value:1.32E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.64|P-value:2.58E-7 ID:SGTC_2979|Compound:9012552|FD-Score:-3.23|P-value:3.27E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.12|P-value:5.02E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-3.54|P-value:9.31E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.35|P-value:1.33E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.04|P-value:4.64E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.39|P-value:1.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.42|P-value:8.52E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.05|P-value:6.51E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-3.55|P-value:8.92E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.09|P-value:5.50E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.17|P-value:2.84E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.26|P-value:1.99E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.31|P-value:1.56E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.05|P-value:6.61E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.51|P-value:6.96E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:2.99|P-value:5.70E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.08|P-value:4.00E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.38|P-value:1.81E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-8.83|P-value:2.51E-21 ID:SGTC_974|Compound:1326-0144|FD-Score:3.96|P-value:8.57E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.96|P-value:8.85E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.21|P-value:3.57E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-4.68|P-value:3.54E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.37|P-value:1.09E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.96|P-value:8.53E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.47|P-value:8.00E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:2.86|P-value:9.06E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:5.58|P-value:7.87E-10 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.57|P-value:3.62E-7 ID:SGTC_1571|Compound:st070080|FD-Score:3.72|P-value:2.70E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-3.35|P-value:2.05E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.67|P-value:3.41E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.57|P-value:5.37E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_1973|Compound:st070275|FD-Score:2.87|P-value:8.67E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.00|P-value:5.40E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.13|P-value:4.74E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.42|P-value:1.02E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-2.96|P-value:9.05E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_2302|Compound:7771753|FD-Score:2.88|P-value:8.47E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.07|P-value:6.07E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-4.00|P-value:1.15E-5 ID:SGTC_2813|Compound:7971799|FD-Score:5.11|P-value:1.60E-8 ID:SGTC_2933|Compound:9026794|FD-Score:3.36|P-value:1.32E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.64|P-value:2.58E-7 ID:SGTC_2979|Compound:9012552|FD-Score:-3.23|P-value:3.27E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.12|P-value:5.02E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-3.54|P-value:9.31E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.35|P-value:1.33E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.04|P-value:4.64E-4

Top fitness defect scores for YPL113C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1380 2291-0730 5.58 164.0 µM 7.87E-10 3 1.17E-8
2 SGTC_2813 7971799 5.11 71.4 µM 1.60E-8 7 1.59E-7
3 SGTC_2934 9036370 4.64 36.9 µM 2.58E-7 17 1.78E-6
4 SGTC_1474 0330-0125 4.57 5.3 µM 3.62E-7 15 2.39E-6
5 SGTC_103 0844-0104 4.42 51.8 µM 8.52E-7 ERAD & cell cycle 123 5.01E-6
6 SGTC_1197 1601-0112 4.37 267.0 µM 1.09E-6 9 6.19E-6
7 SGTC_1269 0831-0796 3.96 3.0 µM 8.53E-6 60S ribosome export 14 3.69E-5
8 SGTC_974 1326-0144 3.96 138.0 µM 8.57E-6 ERG2 41 3.70E-5
9 SGTC_1000 4048-0884 3.96 8.7 µM 8.85E-6 copper-dependent oxidative stress 32 3.81E-5
10 SGTC_1571 st070080 3.72 73.4 µM 2.70E-5 23 1.00E-4
11 SGTC_1870 st057514 3.67 26.5 µM 3.41E-5 RSC & ERG11 34 1.23E-4
12 SGTC_1894 3',6'-dihydroxyflavone 3.57 78.7 µM 5.37E-5 21 1.82E-4
13 SGTC_724 3910-0327 3.51 137.0 µM 6.96E-5 ERG2 32 2.27E-4
14 SGTC_1301 naphtanilide LB 3.47 4.8 µM 8.00E-5 heme requiring 19 2.57E-4
15 SGTC_2167 5876490 3.42 200.0 µM 1.02E-4 53 3.16E-4
16 SGTC_2933 9026794 3.36 32.5 µM 1.32E-4 51 3.96E-4
17 SGTC_3133 9127736 3.35 49.5 µM 1.33E-4 39 3.99E-4
18 SGTC_598 3937-0236 3.31 20.2 µM 1.56E-4 ERG2 49 4.59E-4
19 SGTC_2292 7671323 3.30 168.1 µM 1.66E-4 RNA processing & uracil transport 68 4.83E-4
20 SGTC_58 0957-0393 3.30 9.0 µM 1.66E-4 cell wall 453 4.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 5.74E-40 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.215 1.48E-36 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.210 8.12E-35 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.193 2.03E-29 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.189 2.02E-28 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.188 6.44E-28 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.186 1.34E-27 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.180 7.05E-26 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.175 1.95E-24 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.170 2.91E-23 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.167 1.93E-22 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.166 2.88E-22 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.158 3.12E-20 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.158 4.08E-20 YDR242W AMD2 hom Putative amidase
0.157 5.08E-20 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats