YPL121C / MEI5

Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL121C / MEI5

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:3.47|P-value:4.40E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.96|P-value:4.29E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.45|P-value:5.14E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.97|P-value:3.73E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.38|P-value:3.82E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:-2.99|P-value:3.79E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.06|P-value:2.70E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:2.78|P-value:8.33E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.13|P-value:1.54E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.80|P-value:9.19E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.05|P-value:2.89E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.94|P-value:4.41E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.17|P-value:1.74E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.15|P-value:1.90E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.13|P-value:2.03E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.98|P-value:3.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.87|P-value:2.00E-8 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.99|P-value:3.61E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.78|P-value:8.60E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.55|P-value:2.99E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.79|P-value:8.23E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.95|P-value:4.36E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.03|P-value:2.65E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.17|P-value:1.74E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.57|P-value:2.89E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.01|P-value:3.10E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.55|P-value:3.12E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.85|P-value:6.34E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.52|P-value:3.51E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.60|P-value:2.42E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-2.82|P-value:7.47E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.49|P-value:2.04E-7 ID:SGTC_2318|Compound:6029776|FD-Score:4.25|P-value:7.77E-7 ID:SGTC_2363|Compound:9053361|FD-Score:2.91|P-value:5.02E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-2.77|P-value:8.81E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.43|P-value:5.25E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.89|P-value:5.63E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.61|P-value:2.33E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.14|P-value:1.47E-6 ID:SGTC_2693|Compound:st077581|FD-Score:2.96|P-value:4.11E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-2.78|P-value:8.56E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.22|P-value:1.40E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.06|P-value:2.77E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.47|P-value:4.40E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.96|P-value:4.29E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.45|P-value:5.14E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.97|P-value:3.73E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.38|P-value:3.82E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:-2.99|P-value:3.79E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.06|P-value:2.70E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:2.78|P-value:8.33E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.13|P-value:1.54E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.80|P-value:9.19E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.05|P-value:2.89E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.94|P-value:4.41E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.17|P-value:1.74E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.15|P-value:1.90E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.13|P-value:2.03E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.98|P-value:3.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.87|P-value:2.00E-8 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.99|P-value:3.61E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.78|P-value:8.60E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.55|P-value:2.99E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.79|P-value:8.23E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.95|P-value:4.36E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.03|P-value:2.65E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.17|P-value:1.74E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.57|P-value:2.89E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.01|P-value:3.10E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.55|P-value:3.12E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.85|P-value:6.34E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.52|P-value:3.51E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.60|P-value:2.42E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-2.82|P-value:7.47E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.49|P-value:2.04E-7 ID:SGTC_2318|Compound:6029776|FD-Score:4.25|P-value:7.77E-7 ID:SGTC_2363|Compound:9053361|FD-Score:2.91|P-value:5.02E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-2.77|P-value:8.81E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.43|P-value:5.25E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.89|P-value:5.63E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.61|P-value:2.33E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.14|P-value:1.47E-6 ID:SGTC_2693|Compound:st077581|FD-Score:2.96|P-value:4.11E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-2.78|P-value:8.56E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.22|P-value:1.40E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.06|P-value:2.77E-4

Top fitness defect scores for YPL121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2316 5844804 4.49 197.4 µM 2.04E-7 13 3.63E-6
2 SGTC_2318 6029776 4.25 164.0 µM 7.77E-7 18 1.05E-5
3 SGTC_2605 digitonin 4.14 300.0 nM 1.47E-6 24 1.74E-5
4 SGTC_350 k064-0020 4.13 19.8 µM 1.54E-6 heme requiring 23 1.80E-5
5 SGTC_1606 st000094 4.03 49.2 µM 2.65E-6 60S ribosome export 15 2.77E-5
6 SGTC_130 0136-0219 3.97 337.7 µM 3.73E-6 21 3.63E-5
7 SGTC_2514 salinomycin 3.61 42.7 µM 2.33E-5 66 1.55E-4
8 SGTC_2125 5246583 3.60 200.0 µM 2.42E-5 tubulin folding & SWR complex 53 1.60E-4
9 SGTC_1132 3456-3614 3.55 2.5 µM 2.99E-5 tubulin folding & SWR complex 73 1.90E-4
10 SGTC_2048 5246248 3.52 200.0 µM 3.51E-5 12 2.16E-4
11 SGTC_57 miconazole 3.47 162.5 nM 4.40E-5 ergosterol depletion effects on membrane 36 2.58E-4
12 SGTC_2497 7-hydroxyflavone 3.43 100.0 µM 5.25E-5 30 2.97E-4
13 SGTC_3150 9097574 3.22 49.5 µM 1.40E-4 24 6.49E-4
14 SGTC_1675 st018485 3.17 24.5 µM 1.74E-4 60S ribosome export 62 7.70E-4
15 SGTC_716 1683-5115 3.15 658.0 µM 1.90E-4 51 8.26E-4
16 SGTC_933 2914-0560 3.13 114.0 µM 2.03E-4 61 8.71E-4
17 SGTC_326 k292-0812 3.06 17.5 µM 2.70E-4 25 0.00110
18 SGTC_3152 9099253 3.06 49.5 µM 2.77E-4 NEO1-PIK1 202 0.00112
19 SGTC_402 epigallocatechin gallate 3.05 10.0 µM 2.89E-4 78 0.00115
20 SGTC_1125 tnp00248 2.99 1.3 µM 3.61E-4 99 0.00138

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 3.56E-48 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.216 6.87E-37 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.216 9.75E-37 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.206 2.32E-33 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.204 5.50E-33 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.196 1.65E-30 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.191 5.28E-29 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.179 1.77E-25 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.162 3.11E-21 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.162 3.95E-21 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.161 6.39E-21 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.161 8.17E-21 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.159 1.71E-20 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.158 3.60E-20 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.157 5.17E-20 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E