YPL125W / KAP120

Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL125W / KAP120

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.49|P-value:3.81E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.64|P-value:2.22E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.91|P-value:1.25E-6 ID:SGTC_297|Compound:0986-0032|FD-Score:3.25|P-value:9.31E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.00|P-value:5.87E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.12|P-value:3.65E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.35|P-value:1.29E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:4.05|P-value:5.18E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.86|P-value:9.27E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:10.50|P-value:2.42E-24 ID:SGTC_365|Compound:0121-0052|FD-Score:5.10|P-value:4.93E-7 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.49|P-value:3.78E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.33|P-value:7.07E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.89|P-value:8.82E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.41|P-value:9.44E-8 ID:SGTC_782|Compound:0083-0095|FD-Score:4.88|P-value:1.42E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.84|P-value:1.14E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.65|P-value:2.30E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.38|P-value:6.01E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-5.96|P-value:4.69E-9 ID:SGTC_1456|Compound:k015-0012|FD-Score:-4.18|P-value:2.85E-5 ID:SGTC_1628|Compound:st004252|FD-Score:-3.40|P-value:5.30E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.64|P-value:3.96E-6 ID:SGTC_1839|Compound:st053978|FD-Score:5.29|P-value:1.90E-7 ID:SGTC_1847|Compound:st056231|FD-Score:3.56|P-value:3.17E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.11|P-value:4.02E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.29|P-value:8.15E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.84|P-value:1.17E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.43|P-value:5.11E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.93|P-value:6.20E-9 ID:SGTC_2282|Compound:7944268|FD-Score:3.36|P-value:6.43E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.33|P-value:6.98E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.66|P-value:2.83E-8 ID:SGTC_2390|Compound:9097792|FD-Score:4.27|P-value:2.07E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.38|P-value:6.04E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.76|P-value:2.43E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.03|P-value:7.09E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.34|P-value:6.34E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.30|P-value:1.83E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.96|P-value:5.40E-9 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.93|P-value:8.29E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.44|P-value:4.91E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.60|P-value:2.63E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.37|P-value:1.39E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.49|P-value:3.77E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.16|P-value:3.09E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.29|P-value:7.98E-4 ID:SGTC_2972|Compound:9093619|FD-Score:6.50|P-value:2.16E-10 ID:SGTC_2996|Compound:9066192|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.95|P-value:7.60E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.36|P-value:6.29E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.12|P-value:3.89E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.75|P-value:1.62E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.30|P-value:7.66E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.49|P-value:3.81E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.64|P-value:2.22E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.91|P-value:1.25E-6 ID:SGTC_297|Compound:0986-0032|FD-Score:3.25|P-value:9.31E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.00|P-value:5.87E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.12|P-value:3.65E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.35|P-value:1.29E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:4.05|P-value:5.18E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.86|P-value:9.27E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:10.50|P-value:2.42E-24 ID:SGTC_365|Compound:0121-0052|FD-Score:5.10|P-value:4.93E-7 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.49|P-value:3.78E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.33|P-value:7.07E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.89|P-value:8.82E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.41|P-value:9.44E-8 ID:SGTC_782|Compound:0083-0095|FD-Score:4.88|P-value:1.42E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.84|P-value:1.14E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.65|P-value:2.30E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.38|P-value:6.01E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-5.96|P-value:4.69E-9 ID:SGTC_1456|Compound:k015-0012|FD-Score:-4.18|P-value:2.85E-5 ID:SGTC_1628|Compound:st004252|FD-Score:-3.40|P-value:5.30E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.64|P-value:3.96E-6 ID:SGTC_1839|Compound:st053978|FD-Score:5.29|P-value:1.90E-7 ID:SGTC_1847|Compound:st056231|FD-Score:3.56|P-value:3.17E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.11|P-value:4.02E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.29|P-value:8.15E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.84|P-value:1.17E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.43|P-value:5.11E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.93|P-value:6.20E-9 ID:SGTC_2282|Compound:7944268|FD-Score:3.36|P-value:6.43E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.33|P-value:6.98E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.66|P-value:2.83E-8 ID:SGTC_2390|Compound:9097792|FD-Score:4.27|P-value:2.07E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.38|P-value:6.04E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.76|P-value:2.43E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.03|P-value:7.09E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.34|P-value:6.34E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.30|P-value:1.83E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.96|P-value:5.40E-9 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.93|P-value:8.29E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.44|P-value:4.91E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.60|P-value:2.63E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.37|P-value:1.39E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.49|P-value:3.77E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.16|P-value:3.09E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.29|P-value:7.98E-4 ID:SGTC_2972|Compound:9093619|FD-Score:6.50|P-value:2.16E-10 ID:SGTC_2996|Compound:9066192|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.95|P-value:7.60E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.36|P-value:6.29E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.12|P-value:3.89E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.75|P-value:1.62E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.30|P-value:7.66E-4

Top fitness defect scores for YPL125W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_364 0083-0097 10.50 67.7 µM 2.42E-24 1 3.20E-26
2 SGTC_2972 9093619 6.50 59.9 µM 2.16E-10 2 3.97E-11
3 SGTC_2688 kanamycin b 5.96 96.7 µM 5.40E-9 calcium & mitochondrial duress 161 1.29E-9
4 SGTC_2268 7933382 5.93 153.8 µM 6.20E-9 9 1.50E-9
5 SGTC_363 0455-0021 5.86 3.1 µM 9.27E-9 azole & statin 35 2.31E-9
6 SGTC_2313 7726885 5.66 200.0 µM 2.83E-8 RPP1 & pyrimidine depletion 10 7.72E-9
7 SGTC_1839 st053978 5.29 48.0 µM 1.90E-7 5 6.06E-8
8 SGTC_365 0121-0052 5.10 13.6 µM 4.93E-7 mitochondrial response to ROS 28 1.69E-7
9 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 5.03 54.6 µM 7.09E-7 RPP1 & pyrimidine depletion 14 2.51E-7
10 SGTC_118 0083-0097 4.91 135.3 µM 1.25E-6 translation 63 4.62E-7
11 SGTC_782 0083-0095 4.88 30.5 µM 1.42E-6 11 5.33E-7
12 SGTC_2502 avocadyne acetate 4.76 18.6 µM 2.43E-6 14 9.50E-7
13 SGTC_2819 7996655 4.37 46.4 µM 1.39E-5 14 6.27E-6
14 SGTC_2617 dihydrotanshinone i 4.30 20.8 µM 1.83E-5 copper-dependent oxidative stress 31 8.44E-6
15 SGTC_2390 9097792 4.27 176.6 µM 2.07E-5 9 9.63E-6
16 SGTC_3148 9097893 4.12 49.5 µM 3.89E-5 34 1.90E-5
17 SGTC_1885 st057546 4.11 99.9 µM 4.02E-5 17 1.97E-5
18 SGTC_358 0075-0058 4.05 9.4 µM 5.18E-5 57 2.59E-5
19 SGTC_3043 9092303 3.95 49.5 µM 7.60E-5 16 3.92E-5
20 SGTC_2775 cyproheptadine 3.93 69.6 µM 8.29E-5 19 4.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.274 9.97E-59 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.180 5.78E-26 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.156 8.62E-20 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.155 1.50E-19 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.154 2.76E-19 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.149 4.50E-18 YHR010W RPL27A hom Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication
0.148 5.49E-18 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.147 1.19E-17 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.147 1.43E-17 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.146 1.49E-17 YNL248C RPA49 hom RNA polymerase I subunit A49
0.143 9.83E-17 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.139 7.99E-16 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex
0.136 2.41E-15 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.131 3.18E-14 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.130 4.72E-14 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication