HIPHOP chemogenomics database

YPL130W / SPO19

Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL130W / SPO19

Click on Significant Values for Screen Details

Top fitness defect scores for YPL130W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1177	0983-0204	4.87	23.6 µM	4.50E-8		5	5.70E-7
2	SGTC_1596	piperlongumine	4.46	63.0 µM	4.65E-7		6	4.04E-6
3	SGTC_1498	4478-3555	4.39	97.6 µM	6.80E-7		3	5.56E-6
4	SGTC_3341	9147222	4.30	25.9 µM	1.15E-6	RNA processing & uracil transport	9	8.63E-6
5	SGTC_1158	4092-0494	4.01	91.8 µM	5.24E-6		15	3.08E-5
6	SGTC_1678	st019265	3.80	80.2 µM	1.43E-5	60S ribosome export	24	7.14E-5
7	SGTC_1787	fluconazole	3.78	80.0 µM	1.62E-5	iron homeostasis	30	7.94E-5
8	SGTC_2365	9042475	3.71	200.0 µM	2.22E-5		46	1.03E-4
9	SGTC_1502	4534-4282	3.68	27.7 µM	2.61E-5		18	1.19E-4
10	SGTC_3340	9146634	3.64	11.1 µM	3.02E-5		20	1.34E-4
11	SGTC_565	1418-0001	3.57	44.5 µM	4.16E-5		34	1.76E-4
12	SGTC_1846	st056244	3.55	14.8 µM	4.64E-5		45	1.92E-4
13	SGTC_2899	9053889	3.54	58.4 µM	4.82E-5		18	1.99E-4
14	SGTC_2598	perillyl alcohol	3.46	100.0 µM	6.91E-5		53	2.69E-4
15	SGTC_795	0685-0265	3.37	78.0 µM	1.04E-4	excess fatty acid	44	3.78E-4
16	SGTC_2696	st077691	3.35	74.3 µM	1.14E-4		50	4.11E-4
17	SGTC_1164	k060-0068	3.27	93.7 µM	1.57E-4		59	5.36E-4
18	SGTC_2412	st077135	3.27	33.4 µM	1.60E-4		51	5.46E-4
19	SGTC_3345	9148410	3.26	3.6 µM	1.63E-4		22	5.52E-4
20	SGTC_793	0488-0545	3.26	106.0 µM	1.63E-4		29	5.54E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.207	1.45E-33	YIR013C	GAT4	hom	Protein containing GATA family zinc finger motifs
0.132	1.86E-14	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.105	1.19E-9	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.102	3.52E-9	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.100	5.71E-9	YJR031C	GEA1	hom	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
0.095	3.90E-8	YMR137C	PSO2	hom	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.086	5.32E-7	YBR010W	HHT1	hom	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
0.084	1.09E-6	YGR237C_p	YGR237C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.082	2.30E-6	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.080	3.54E-6	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.080	4.00E-6	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.079	4.09E-6	YPL264C_p	YPL264C_p	hom	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
0.079	4.17E-6	YPL072W	UBP16	hom	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
0.079	4.96E-6	YOR139C_d	YOR139C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W
0.077	7.31E-6	YJL061W	NUP82	het	Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)