YPL130W / SPO19

Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL130W / SPO19

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:-6.15|P-value:1.14E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.70|P-value:2.92E-10 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.96|P-value:6.75E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.57|P-value:4.16E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.39|P-value:1.18E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.37|P-value:1.04E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.10|P-value:3.91E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.92|P-value:7.82E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:2.94|P-value:5.98E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.01|P-value:5.24E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.27|P-value:1.57E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.87|P-value:4.50E-8 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.07|P-value:3.63E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.84|P-value:8.78E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.15|P-value:2.62E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.83|P-value:1.64E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.98|P-value:7.77E-6 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.39|P-value:6.80E-7 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.68|P-value:2.61E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.01|P-value:4.57E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.46|P-value:4.65E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.00|P-value:5.78E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.80|P-value:1.43E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.78|P-value:1.62E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.55|P-value:4.64E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-2.88|P-value:9.12E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.71|P-value:2.22E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-2.95|P-value:7.02E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.21|P-value:2.53E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.65|P-value:3.81E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.46|P-value:6.91E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-5.70|P-value:2.83E-10 ID:SGTC_2696|Compound:st077691|FD-Score:3.35|P-value:1.14E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.09|P-value:4.17E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.08|P-value:3.39E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.54|P-value:4.82E-5 ID:SGTC_3199|Compound:9111318|FD-Score:2.82|P-value:9.43E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.64|P-value:3.02E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.30|P-value:1.15E-6 ID:SGTC_3345|Compound:9148410|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-6.15|P-value:1.14E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.70|P-value:2.92E-10 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.96|P-value:6.75E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.57|P-value:4.16E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.39|P-value:1.18E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.37|P-value:1.04E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.10|P-value:3.91E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.92|P-value:7.82E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:2.94|P-value:5.98E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.01|P-value:5.24E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.27|P-value:1.57E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.87|P-value:4.50E-8 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.07|P-value:3.63E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.84|P-value:8.78E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.15|P-value:2.62E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.83|P-value:1.64E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.98|P-value:7.77E-6 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.39|P-value:6.80E-7 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.68|P-value:2.61E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.01|P-value:4.57E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.46|P-value:4.65E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.00|P-value:5.78E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.80|P-value:1.43E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.78|P-value:1.62E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.55|P-value:4.64E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-2.88|P-value:9.12E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.71|P-value:2.22E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-2.95|P-value:7.02E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.21|P-value:2.53E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.65|P-value:3.81E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.46|P-value:6.91E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-5.70|P-value:2.83E-10 ID:SGTC_2696|Compound:st077691|FD-Score:3.35|P-value:1.14E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.09|P-value:4.17E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.08|P-value:3.39E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.54|P-value:4.82E-5 ID:SGTC_3199|Compound:9111318|FD-Score:2.82|P-value:9.43E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.64|P-value:3.02E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.30|P-value:1.15E-6 ID:SGTC_3345|Compound:9148410|FD-Score:3.26|P-value:1.63E-4

Top fitness defect scores for YPL130W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1177 0983-0204 4.87 23.6 µM 4.50E-8 5 5.70E-7
2 SGTC_1596 piperlongumine 4.46 63.0 µM 4.65E-7 6 4.04E-6
3 SGTC_1498 4478-3555 4.39 97.6 µM 6.80E-7 3 5.56E-6
4 SGTC_3341 9147222 4.30 25.9 µM 1.15E-6 RNA processing & uracil transport 9 8.63E-6
5 SGTC_1158 4092-0494 4.01 91.8 µM 5.24E-6 15 3.08E-5
6 SGTC_1678 st019265 3.80 80.2 µM 1.43E-5 60S ribosome export 24 7.14E-5
7 SGTC_1787 fluconazole 3.78 80.0 µM 1.62E-5 iron homeostasis 30 7.94E-5
8 SGTC_2365 9042475 3.71 200.0 µM 2.22E-5 46 1.03E-4
9 SGTC_1502 4534-4282 3.68 27.7 µM 2.61E-5 18 1.19E-4
10 SGTC_3340 9146634 3.64 11.1 µM 3.02E-5 20 1.34E-4
11 SGTC_565 1418-0001 3.57 44.5 µM 4.16E-5 34 1.76E-4
12 SGTC_1846 st056244 3.55 14.8 µM 4.64E-5 45 1.92E-4
13 SGTC_2899 9053889 3.54 58.4 µM 4.82E-5 18 1.99E-4
14 SGTC_2598 perillyl alcohol 3.46 100.0 µM 6.91E-5 53 2.69E-4
15 SGTC_795 0685-0265 3.37 78.0 µM 1.04E-4 excess fatty acid 44 3.78E-4
16 SGTC_2696 st077691 3.35 74.3 µM 1.14E-4 50 4.11E-4
17 SGTC_1164 k060-0068 3.27 93.7 µM 1.57E-4 59 5.36E-4
18 SGTC_2412 st077135 3.27 33.4 µM 1.60E-4 51 5.46E-4
19 SGTC_3345 9148410 3.26 3.6 µM 1.63E-4 22 5.52E-4
20 SGTC_793 0488-0545 3.26 106.0 µM 1.63E-4 29 5.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.45E-33 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.132 1.86E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.105 1.19E-9 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.102 3.52E-9 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.100 5.71E-9 YJR031C GEA1 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
0.095 3.90E-8 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.086 5.32E-7 YBR010W HHT1 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
0.084 1.09E-6 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.082 2.30E-6 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.080 3.54E-6 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.080 4.00E-6 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.079 4.09E-6 YPL264C_p YPL264C_p hom Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
0.079 4.17E-6 YPL072W UBP16 hom Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
0.079 4.96E-6 YOR139C_d YOR139C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W
0.077 7.31E-6 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)