YPL142C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL142C / YPL142C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.65|P-value:3.19E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.38|P-value:8.04E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.78|P-value:2.06E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.31|P-value:8.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.89|P-value:1.16E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.28|P-value:9.27E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.40|P-value:1.60E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.73|P-value:3.85E-6 ID:SGTC_394|Compound:menadione|FD-Score:-6.46|P-value:5.30E-10 ID:SGTC_490|Compound:phenamil|FD-Score:-3.37|P-value:6.95E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.97|P-value:8.59E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.85|P-value:1.36E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-6.31|P-value:1.23E-9 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.31|P-value:8.62E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.38|P-value:2.06E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.61|P-value:3.10E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.56|P-value:4.37E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.18|P-value:4.58E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.35|P-value:7.57E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.40|P-value:6.41E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.44|P-value:6.60E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.30|P-value:2.91E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.62|P-value:3.00E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.56|P-value:4.34E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.67|P-value:3.03E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-4.45|P-value:1.27E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-3.61|P-value:3.14E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.41|P-value:1.53E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.60|P-value:3.30E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.23|P-value:3.11E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.84|P-value:1.37E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.96|P-value:1.05E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.57|P-value:4.25E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.56|P-value:9.79E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.96|P-value:1.05E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.59|P-value:3.97E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.33|P-value:2.07E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.45|P-value:6.26E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.65|P-value:5.53E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:-6.03|P-value:6.11E-9 ID:SGTC_2849|Compound:9019321|FD-Score:-4.37|P-value:1.76E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-3.50|P-value:4.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-5.44|P-value:1.36E-7 ID:SGTC_2989|Compound:9073649|FD-Score:3.81|P-value:1.85E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-5.56|P-value:7.58E-8 ID:SGTC_2993|Compound:9054257|FD-Score:3.76|P-value:2.18E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.92|P-value:2.06E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.43|P-value:6.74E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.63|P-value:3.50E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.45|P-value:6.25E-4 ID:SGTC_3164|Compound:9100705|FD-Score:4.11|P-value:6.04E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.30|P-value:8.93E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-4.77|P-value:3.18E-6 ID:SGTC_3180|Compound:9109287|FD-Score:4.10|P-value:6.32E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-4.70|P-value:4.39E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.96|P-value:1.08E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.61|P-value:3.16E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.65|P-value:3.19E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.38|P-value:8.04E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.78|P-value:2.06E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.31|P-value:8.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.89|P-value:1.16E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.28|P-value:9.27E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.40|P-value:1.60E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.73|P-value:3.85E-6 ID:SGTC_394|Compound:menadione|FD-Score:-6.46|P-value:5.30E-10 ID:SGTC_490|Compound:phenamil|FD-Score:-3.37|P-value:6.95E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.97|P-value:8.59E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.85|P-value:1.36E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-6.31|P-value:1.23E-9 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.31|P-value:8.62E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.38|P-value:2.06E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.61|P-value:3.10E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.56|P-value:4.37E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.18|P-value:4.58E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.35|P-value:7.57E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.40|P-value:6.41E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.44|P-value:6.60E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.30|P-value:2.91E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.62|P-value:3.00E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.56|P-value:4.34E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.67|P-value:3.03E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-4.45|P-value:1.27E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-3.61|P-value:3.14E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.41|P-value:1.53E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.60|P-value:3.30E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.23|P-value:3.11E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.84|P-value:1.37E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.96|P-value:1.05E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.57|P-value:4.25E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.56|P-value:9.79E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.96|P-value:1.05E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.59|P-value:3.97E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.33|P-value:2.07E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.45|P-value:6.26E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.65|P-value:5.53E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:-6.03|P-value:6.11E-9 ID:SGTC_2849|Compound:9019321|FD-Score:-4.37|P-value:1.76E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-3.50|P-value:4.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-5.44|P-value:1.36E-7 ID:SGTC_2989|Compound:9073649|FD-Score:3.81|P-value:1.85E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-5.56|P-value:7.58E-8 ID:SGTC_2993|Compound:9054257|FD-Score:3.76|P-value:2.18E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.92|P-value:2.06E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.43|P-value:6.74E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.63|P-value:3.50E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.45|P-value:6.25E-4 ID:SGTC_3164|Compound:9100705|FD-Score:4.11|P-value:6.04E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.30|P-value:8.93E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-4.77|P-value:3.18E-6 ID:SGTC_3180|Compound:9109287|FD-Score:4.10|P-value:6.32E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-4.70|P-value:4.39E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.96|P-value:1.08E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.61|P-value:3.16E-4

Top fitness defect scores for YPL142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2998 9066762 4.92 71.4 µM 2.06E-6 RPP1 & pyrimidine depletion 5 4.33E-7 0.42
2 SGTC_2170 morpholine 4.56 200.0 µM 9.79E-6 2 2.52E-6 0.32
3 SGTC_864 0469-0573 4.38 172.0 µM 2.06E-5 1 5.82E-6 0.28
4 SGTC_1252 0493-0875 4.30 34.8 µM 2.91E-5 5 8.61E-6 0.08
5 SGTC_978 1416-0512 4.18 87.4 µM 4.58E-5 redox potentiating 6 1.44E-5 0.03
6 SGTC_3164 9100705 4.11 49.5 µM 6.04E-5 1 1.97E-5 0.71
7 SGTC_3180 9109287 4.10 49.5 µM 6.32E-5 2 2.07E-5 0.24
8 SGTC_1931 st074438 3.96 57.1 µM 1.05E-4 10 3.67E-5 9.63E-4
9 SGTC_2308 7584454 3.96 197.6 µM 1.05E-4 10 3.68E-5 0.38
10 SGTC_3269 9137823 3.96 49.5 µM 1.08E-4 60S ribosome export 4 3.80E-5 0.52
11 SGTC_2989 9073649 3.81 71.4 µM 1.85E-4 10 6.95E-5 0.03
12 SGTC_258 haloperidol 3.78 50.8 µM 2.06E-4 fatty acid desaturase (OLE1) 21 7.86E-5 0.15
13 SGTC_2993 9054257 3.76 71.4 µM 2.18E-4 fatty acid desaturase (OLE1) 33 8.37E-5 0.04
14 SGTC_1641 st009299 3.67 47.1 µM 3.03E-4 mitochondrial processes 5 1.22E-4 0.20
15 SGTC_35 0133-0054 3.65 64.1 µM 3.19E-4 12 1.29E-4 0.07
16 SGTC_3054 9094397 3.63 49.5 µM 3.50E-4 fatty acid desaturase (OLE1) 11 1.43E-4 0.11
17 SGTC_2393 9031399 3.59 185.9 µM 3.97E-4 RNA processing & uracil transport 16 1.65E-4 0.08
18 SGTC_2050 5263056 3.57 171.0 µM 4.25E-4 fatty acid desaturase (OLE1) 33 1.78E-4 0.16
19 SGTC_1307 1187-1599 3.56 12.2 µM 4.34E-4 PDR1 6 1.82E-4 0.09
20 SGTC_977 1348-1378 3.56 135.0 µM 4.37E-4 12 1.84E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 4.04E-44 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.185 2.88E-27 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.177 9.06E-25 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.165 9.66E-22 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.155 1.66E-19 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.155 1.83E-19 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.148 7.97E-18 YKL180W RPL17A het Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.136 3.40E-15 YBR140C IRA1 het GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
0.133 1.33E-14 YLR075W RPL10 het Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
0.124 7.75E-13 YOR224C RPB8 het RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
0.123 9.94E-13 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.117 9.21E-12 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.117 1.23E-11 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.117 1.25E-11 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.115 2.39E-11 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation