YPL145C / KES1

One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL145C / KES1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:5.42|P-value:3.74E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.29|P-value:9.09E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.97|P-value:1.79E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:11.90|P-value:8.12E-28 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.20|P-value:7.81E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:14.60|P-value:2.62E-40 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.80|P-value:3.17E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.81|P-value:2.41E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:9.79|P-value:2.39E-19 ID:SGTC_187|Compound:1488-2104|FD-Score:7.72|P-value:9.84E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.54|P-value:7.39E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.70|P-value:9.85E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:14.60|P-value:2.14E-40 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.75|P-value:9.28E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.92|P-value:2.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.27|P-value:7.39E-7 ID:SGTC_447|Compound:ml7|FD-Score:6.66|P-value:6.06E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.10|P-value:1.87E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:4.33|P-value:3.73E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:12.80|P-value:1.90E-31 ID:SGTC_532|Compound:1548-0774|FD-Score:3.71|P-value:3.40E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.43|P-value:2.56E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.68|P-value:9.37E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:5.00|P-value:2.45E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:5.20|P-value:1.04E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:12.30|P-value:3.33E-29 ID:SGTC_583|Compound:1488-1091|FD-Score:3.62|P-value:4.61E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.77|P-value:6.92E-8 ID:SGTC_740|Compound:k014-0057|FD-Score:3.51|P-value:6.57E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.51|P-value:1.85E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:7.70|P-value:1.09E-12 ID:SGTC_859|Compound:0439-0102|FD-Score:3.71|P-value:3.40E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:4.11|P-value:8.51E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.85|P-value:2.10E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.48|P-value:8.77E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-6.73|P-value:5.99E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.42|P-value:2.68E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:6.24|P-value:6.18E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:-5.36|P-value:6.76E-7 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.39|P-value:9.34E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.13|P-value:1.11E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.62|P-value:4.54E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.49|P-value:2.03E-5 ID:SGTC_1712|Compound:st032288|FD-Score:12.70|P-value:2.01E-31 ID:SGTC_1750|Compound:st081859|FD-Score:3.61|P-value:4.72E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.87|P-value:4.22E-8 ID:SGTC_1760|Compound:st045453|FD-Score:11.10|P-value:1.76E-24 ID:SGTC_1800|Compound:st050079|FD-Score:10.40|P-value:1.93E-21 ID:SGTC_1801|Compound:st050089|FD-Score:4.21|P-value:5.87E-5 ID:SGTC_1803|Compound:st050068|FD-Score:15.20|P-value:4.97E-44 ID:SGTC_1818|Compound:st052136|FD-Score:5.14|P-value:1.35E-6 ID:SGTC_1830|Compound:st055982|FD-Score:3.48|P-value:7.14E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-4.54|P-value:2.20E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.32|P-value:3.88E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.55|P-value:5.80E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.58|P-value:5.12E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.94|P-value:2.91E-8 ID:SGTC_2021|Compound:4019055|FD-Score:8.87|P-value:3.15E-16 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.92|P-value:1.66E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.52|P-value:7.78E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.57|P-value:1.85E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.41|P-value:2.78E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.47|P-value:7.24E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.50|P-value:1.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.88|P-value:5.51E-13 ID:SGTC_2605|Compound:digitonin|FD-Score:3.66|P-value:4.04E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.88|P-value:4.11E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.65|P-value:1.23E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.74|P-value:3.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.47|P-value:1.74E-9 ID:SGTC_2708|Compound:st078559|FD-Score:4.44|P-value:2.43E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.70|P-value:8.59E-6 ID:SGTC_2808|Compound:7946468|FD-Score:5.32|P-value:5.77E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-4.88|P-value:5.47E-6 ID:SGTC_2839|Compound:9003951|FD-Score:4.14|P-value:7.46E-5 ID:SGTC_3018|Compound:9082602|FD-Score:7.46|P-value:5.20E-12 ID:SGTC_3126|Compound:9127922|FD-Score:3.65|P-value:4.12E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.52|P-value:1.79E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.76|P-value:2.91E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.92|P-value:3.43E-6 ID:SGTC_3278|Compound:9139605|FD-Score:3.98|P-value:1.32E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.70|P-value:3.55E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.87|P-value:1.98E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:5.42|P-value:3.74E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.29|P-value:9.09E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.97|P-value:1.79E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:11.90|P-value:8.12E-28 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.20|P-value:7.81E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:14.60|P-value:2.62E-40 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.80|P-value:3.17E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.81|P-value:2.41E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:9.79|P-value:2.39E-19 ID:SGTC_187|Compound:1488-2104|FD-Score:7.72|P-value:9.84E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.54|P-value:7.39E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.70|P-value:9.85E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:14.60|P-value:2.14E-40 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.75|P-value:9.28E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.92|P-value:2.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.27|P-value:7.39E-7 ID:SGTC_447|Compound:ml7|FD-Score:6.66|P-value:6.06E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.10|P-value:1.87E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:4.33|P-value:3.73E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:12.80|P-value:1.90E-31 ID:SGTC_532|Compound:1548-0774|FD-Score:3.71|P-value:3.40E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.43|P-value:2.56E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.68|P-value:9.37E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:5.00|P-value:2.45E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:5.20|P-value:1.04E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:12.30|P-value:3.33E-29 ID:SGTC_583|Compound:1488-1091|FD-Score:3.62|P-value:4.61E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.77|P-value:6.92E-8 ID:SGTC_740|Compound:k014-0057|FD-Score:3.51|P-value:6.57E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.51|P-value:1.85E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:7.70|P-value:1.09E-12 ID:SGTC_859|Compound:0439-0102|FD-Score:3.71|P-value:3.40E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:4.11|P-value:8.51E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.85|P-value:2.10E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.48|P-value:8.77E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-6.73|P-value:5.99E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.42|P-value:2.68E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:6.24|P-value:6.18E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:-5.36|P-value:6.76E-7 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.39|P-value:9.34E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.13|P-value:1.11E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.62|P-value:4.54E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.49|P-value:2.03E-5 ID:SGTC_1712|Compound:st032288|FD-Score:12.70|P-value:2.01E-31 ID:SGTC_1750|Compound:st081859|FD-Score:3.61|P-value:4.72E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.87|P-value:4.22E-8 ID:SGTC_1760|Compound:st045453|FD-Score:11.10|P-value:1.76E-24 ID:SGTC_1800|Compound:st050079|FD-Score:10.40|P-value:1.93E-21 ID:SGTC_1801|Compound:st050089|FD-Score:4.21|P-value:5.87E-5 ID:SGTC_1803|Compound:st050068|FD-Score:15.20|P-value:4.97E-44 ID:SGTC_1818|Compound:st052136|FD-Score:5.14|P-value:1.35E-6 ID:SGTC_1830|Compound:st055982|FD-Score:3.48|P-value:7.14E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-4.54|P-value:2.20E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.32|P-value:3.88E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.55|P-value:5.80E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.58|P-value:5.12E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.94|P-value:2.91E-8 ID:SGTC_2021|Compound:4019055|FD-Score:8.87|P-value:3.15E-16 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.92|P-value:1.66E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.52|P-value:7.78E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.57|P-value:1.85E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.41|P-value:2.78E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.47|P-value:7.24E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.50|P-value:1.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.88|P-value:5.51E-13 ID:SGTC_2605|Compound:digitonin|FD-Score:3.66|P-value:4.04E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.88|P-value:4.11E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.65|P-value:1.23E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.74|P-value:3.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.47|P-value:1.74E-9 ID:SGTC_2708|Compound:st078559|FD-Score:4.44|P-value:2.43E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.70|P-value:8.59E-6 ID:SGTC_2808|Compound:7946468|FD-Score:5.32|P-value:5.77E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-4.88|P-value:5.47E-6 ID:SGTC_2839|Compound:9003951|FD-Score:4.14|P-value:7.46E-5 ID:SGTC_3018|Compound:9082602|FD-Score:7.46|P-value:5.20E-12 ID:SGTC_3126|Compound:9127922|FD-Score:3.65|P-value:4.12E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.52|P-value:1.79E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.76|P-value:2.91E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.92|P-value:3.43E-6 ID:SGTC_3278|Compound:9139605|FD-Score:3.98|P-value:1.32E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.70|P-value:3.55E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.87|P-value:1.98E-4

Top fitness defect scores for YPL145C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1803 st050068 15.20 52.4 µM 4.97E-44 NEO1-PIK1 3 8.73E-53
2 SGTC_309 k408-0051 14.60 1.5 µM 2.14E-40 2 2.18E-48
3 SGTC_146 3448-8650 14.60 53.1 µM 2.62E-40 NEO1-PIK1 7 2.79E-48
4 SGTC_528 3492-0019 12.80 172.0 µM 1.90E-31 calcium & mitochondrial duress 24 1.46E-37
5 SGTC_1712 st032288 12.70 53.4 µM 2.01E-31 calcium & mitochondrial duress 5 1.57E-37
6 SGTC_582 0987-0078 12.30 156.0 µM 3.33E-29 calcium & mitochondrial duress 4 7.53E-35
7 SGTC_65 0798-0905 11.90 35.0 µM 8.12E-28 calcium & mitochondrial duress 6 3.59E-33
8 SGTC_1760 st045453 11.10 10.4 µM 1.76E-24 NEO1-PIK1 24 3.87E-29
9 SGTC_1800 st050079 10.40 29.1 µM 1.93E-21 NEO1-PIK1 3 1.82E-25
10 SGTC_178 4092-0806 9.79 87.5 µM 2.39E-19 ergosterol depletion effects on membrane 10 6.14E-23
11 SGTC_2021 4019055 8.87 173.0 µM 3.15E-16 endomembrane recycling 18 3.57E-19
12 SGTC_187 1488-2104 7.72 32.7 µM 9.84E-13 calcium & mitochondrial duress 9 5.85E-15
13 SGTC_788 1182-0090 7.70 188.0 µM 1.09E-12 endomembrane recycling 23 6.65E-15
14 SGTC_3018 9082602 7.46 49.5 µM 5.20E-12 20 4.35E-14
15 SGTC_447 ml7 6.66 120.0 µM 6.06E-10 NEO1-PIK1 4 1.34E-11
16 SGTC_2688 kanamycin b 6.47 96.7 µM 1.74E-9 calcium & mitochondrial duress 133 4.76E-11
17 SGTC_1242 0402-0103 6.24 60.1 µM 6.18E-9 7 2.18E-10
18 SGTC_1304 1165-0502 6.13 251.0 µM 1.11E-8 28 4.39E-10
19 SGTC_1913 st060213 5.94 96.1 µM 2.91E-8 6 1.41E-9
20 SGTC_1754 st042065 5.87 16.1 µM 4.22E-8 NEO1-PIK1 102 2.19E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.383 6.36E-118 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.363 5.53E-105 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.344 4.35E-94 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.342 1.20E-92 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.331 1.42E-86 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.330 2.80E-86 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.328 8.40E-85 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.325 1.43E-83 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.323 2.80E-82 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.322 1.18E-81 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.320 1.04E-80 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.314 2.02E-77 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.306 1.21E-73 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.302 2.02E-71 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.301 2.00E-71 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress