YPL147W / PXA1

Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL147W / PXA1

Click on Significant Values for Screen Details ID:SGTC_334|Compound:1502-1024|FD-Score:3.05|P-value:7.19E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.11|P-value:5.73E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.29|P-value:2.91E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.35|P-value:2.31E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.04|P-value:7.41E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.51|P-value:4.30E-9 ID:SGTC_1002|Compound:4049-0206|FD-Score:6.18|P-value:5.47E-11 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.20|P-value:5.69E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.41|P-value:2.10E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.61|P-value:8.09E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.54|P-value:1.10E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.22|P-value:3.82E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.83|P-value:3.20E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.16|P-value:7.13E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.01|P-value:8.25E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.22|P-value:3.93E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.23|P-value:3.72E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.95|P-value:1.87E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.23|P-value:3.65E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.23|P-value:3.78E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.08|P-value:6.52E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.26|P-value:3.32E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.13|P-value:5.41E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.55|P-value:1.06E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.36|P-value:2.69E-6 ID:SGTC_1953|Compound:st076800|FD-Score:4.20|P-value:5.74E-6 ID:SGTC_2035|Compound:5154463|FD-Score:2.98|P-value:9.39E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.87|P-value:2.72E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:2.98|P-value:9.26E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.00|P-value:8.53E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.14|P-value:5.12E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.00|P-value:8.57E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.25|P-value:3.38E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.55|P-value:1.56E-15 ID:SGTC_3071|Compound:9117417|FD-Score:3.18|P-value:4.55E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.82|P-value:3.31E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.79|P-value:3.80E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.59|P-value:8.92E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.05|P-value:7.19E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.11|P-value:5.73E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.29|P-value:2.91E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.35|P-value:2.31E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.04|P-value:7.41E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.51|P-value:4.30E-9 ID:SGTC_1002|Compound:4049-0206|FD-Score:6.18|P-value:5.47E-11 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.20|P-value:5.69E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.41|P-value:2.10E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.61|P-value:8.09E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.54|P-value:1.10E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.22|P-value:3.82E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.83|P-value:3.20E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.16|P-value:7.13E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.01|P-value:8.25E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.22|P-value:3.93E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.23|P-value:3.72E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.95|P-value:1.87E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.23|P-value:3.65E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.23|P-value:3.78E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.08|P-value:6.52E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.26|P-value:3.32E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.13|P-value:5.41E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.55|P-value:1.06E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.36|P-value:2.69E-6 ID:SGTC_1953|Compound:st076800|FD-Score:4.20|P-value:5.74E-6 ID:SGTC_2035|Compound:5154463|FD-Score:2.98|P-value:9.39E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.87|P-value:2.72E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:2.98|P-value:9.26E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.00|P-value:8.53E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.14|P-value:5.12E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.00|P-value:8.57E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.25|P-value:3.38E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.55|P-value:1.56E-15 ID:SGTC_3071|Compound:9117417|FD-Score:3.18|P-value:4.55E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.82|P-value:3.31E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.79|P-value:3.80E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.59|P-value:8.92E-5

Top fitness defect scores for YPL147W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2998 9066762 7.55 71.4 µM 1.56E-15 RPP1 & pyrimidine depletion 1 2.15E-14
2 SGTC_1002 4049-0206 6.18 172.0 µM 5.47E-11 4 3.20E-10
3 SGTC_1000 4048-0884 5.51 8.7 µM 4.30E-9 copper-dependent oxidative stress 12 1.77E-8
4 SGTC_1129 3453-1384 4.41 223.0 µM 2.10E-6 28 5.26E-6
5 SGTC_1950 st077106 4.36 7.2 µM 2.69E-6 RNA processing & uracil transport 18 6.59E-6
6 SGTC_1007 4101-0031 4.20 70.0 µM 5.69E-6 13 1.31E-5
7 SGTC_1953 st076800 4.20 12.1 µM 5.74E-6 42 1.32E-5
8 SGTC_1388 3346-4487 4.16 254.0 µM 7.13E-6 19 1.62E-5
9 SGTC_2347 9049783 3.87 174.8 µM 2.72E-5 33 5.55E-5
10 SGTC_702 1488-0190 3.56 94.0 µM 1.01E-4 amide catabolism 22 1.85E-4
11 SGTC_874 0599-0792 3.54 117.0 µM 1.11E-4 36 2.02E-4
12 SGTC_2595 hexamethylquercetagetin 3.46 100.0 µM 1.49E-4 42 2.66E-4
13 SGTC_652 0437-0092 3.35 114.0 µM 2.31E-4 30 3.98E-4
14 SGTC_817 1391-0715 3.35 46.0 µM 2.39E-4 32 4.11E-4
15 SGTC_1870 st057514 3.26 26.5 µM 3.32E-4 RSC & ERG11 49 5.57E-4
16 SGTC_1783 st039459 3.26 87.5 µM 3.37E-4 Golgi 43 5.64E-4
17 SGTC_1459 k035-0031 3.23 35.7 µM 3.72E-4 DNA intercalators 44 6.17E-4
18 SGTC_1702 st027038 3.23 51.0 µM 3.78E-4 37 6.28E-4
19 SGTC_1406 3909-7906 3.22 11.9 µM 3.93E-4 60S ribosome export 29 6.50E-4
20 SGTC_3071 9117417 3.18 49.5 µM 4.55E-4 fatty acid desaturase (OLE1) 36 7.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.19E-12 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.113 6.24E-11 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.111 9.58E-11 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.111 1.32E-10 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.094 5.71E-8 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.093 7.94E-8 YER101C AST2 hom Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
0.090 1.64E-7 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.088 2.97E-7 YHR146W CRP1 hom Protein that binds to cruciform DNA structures
0.086 5.33E-7 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.082 2.00E-6 YFL017C GNA1 het Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
0.080 3.58E-6 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.078 6.61E-6 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
0.077 7.19E-6 YPL161C BEM4 hom Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
0.076 1.06E-5 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.076 1.08E-5 YER119C AVT6 hom Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication