HIPHOP chemogenomics database

YPL148C / PPT2

Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL148C / PPT2

Click on Significant Values for Screen Details

Top fitness defect scores for YPL148C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	26.20	5.3 µM	2.00E-96		28	6.73E-152
2	SGTC_275	trichlorophene	13.80	5.7 µM	3.52E-28	mitochondrial stress	12	1.25E-43
3	SGTC_386	1509-0011	9.92	3.1 µM	1.82E-15		45	1.66E-23
4	SGTC_37	0566-0070	8.74	1.6 µM	2.16E-12		3	1.19E-18
5	SGTC_36	0335-0881	8.67	14.2 µM	3.23E-12	ubiquinone biosynthesis & proteasome	30	2.25E-18
6	SGTC_134	0269-0018	7.42	6.9 µM	2.05E-9		63	5.93E-14
7	SGTC_119	0121-0043	7.31	24.8 µM	3.40E-9	mitochondrial stress	12	1.31E-13
8	SGTC_1635	st007035	6.85	42.4 µM	2.80E-8		122	3.61E-12
9	SGTC_2287	7945887	6.82	168.8 µM	3.23E-8		1	4.53E-12
10	SGTC_46	0329-0187a	6.81	2.2 µM	3.36E-8		19	4.81E-12
11	SGTC_10	0279-0212	5.73	42.6 µM	2.79E-6	TRP & mitochondrial translation	33	4.95E-9
12	SGTC_70	0141-0289	5.61	43.3 µM	4.32E-6	mitochondrial stress	93	9.85E-9
13	SGTC_970	1315-0089	5.55	19.5 µM	5.52E-6	RSC & ERG11	5	1.44E-8
14	SGTC_1319	1306-0155	5.55	43.7 µM	5.56E-6		3	1.46E-8
15	SGTC_1113	artemisinin	5.38	1.2 µM	1.03E-5	heme biosynthesis & mitochondrial translocase	7	3.80E-8
16	SGTC_2408	sulbentine	5.25	18.4 µM	1.61E-5		27	7.69E-8
17	SGTC_1188	1403-0014	5.19	4.6 µM	1.96E-5	mitochondrial stress	24	1.05E-7
18	SGTC_908	3448-7491	5.17	47.7 µM	2.13E-5	mitochondrial stress	73	1.19E-7
19	SGTC_1109	tnp00067	5.11	928.3 nM	2.58E-5		3	1.61E-7
20	SGTC_173	1273-0061	5.05	2.7 µM	3.19E-5	mitochondrial stress	145	2.24E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.530	2.99E-242	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.514	5.70E-226	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.511	2.20E-222	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.495	1.85E-207	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.491	4.91E-203	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.486	6.66E-199	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.471	8.85E-185	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.456	1.09E-171	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.455	1.65E-171	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.455	7.99E-171	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.448	6.23E-165	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.447	1.18E-164	YGL107C	RMD9	hom	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.442	1.41E-160	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.439	5.77E-158	YBR179C	FZO1	hom	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.438	5.20E-157	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit