YPL150W_p

Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL150W / YPL150W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.75|P-value:7.94E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-5.53|P-value:1.13E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.99|P-value:4.97E-9 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.03|P-value:2.51E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.00|P-value:2.91E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.70|P-value:9.75E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.28|P-value:8.28E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:2.78|P-value:7.01E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.73|P-value:8.72E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.89|P-value:4.52E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.03|P-value:2.34E-12 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.96|P-value:3.46E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.79|P-value:1.50E-11 ID:SGTC_520|Compound:3584-0023|FD-Score:2.98|P-value:3.14E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:2.73|P-value:8.64E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-2.88|P-value:4.64E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.00|P-value:2.90E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.17|P-value:1.39E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.90|P-value:4.37E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:6.43|P-value:7.90E-14 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.40|P-value:4.82E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.49|P-value:1.26E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.64|P-value:1.45E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.87|P-value:4.38E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.86|P-value:5.24E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.04|P-value:2.45E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.35|P-value:6.10E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.82|P-value:6.11E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.17|P-value:1.41E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.76|P-value:7.92E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-4.06|P-value:1.59E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-3.16|P-value:1.42E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.75|P-value:7.88E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.96|P-value:2.68E-6 ID:SGTC_1927|Compound:st060202|FD-Score:3.73|P-value:9.56E-6 ID:SGTC_1936|Compound:st074407|FD-Score:3.08|P-value:2.04E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.39|P-value:5.09E-5 ID:SGTC_2037|Compound:5169046|FD-Score:6.01|P-value:2.66E-12 ID:SGTC_2051|Compound:5263410|FD-Score:2.76|P-value:7.84E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.53|P-value:2.51E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.01|P-value:2.81E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.39|P-value:5.05E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-2.92|P-value:4.03E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-2.93|P-value:3.77E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.27|P-value:8.77E-5 ID:SGTC_2413|Compound:inermin|FD-Score:6.06|P-value:1.78E-12 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.61|P-value:1.69E-14 ID:SGTC_2488|Compound:5268135|FD-Score:3.31|P-value:7.31E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.05|P-value:2.30E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.72|P-value:9.18E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.31|P-value:2.15E-13 ID:SGTC_2835|Compound:9006588|FD-Score:-5.05|P-value:3.28E-9 ID:SGTC_2837|Compound:9008476|FD-Score:6.12|P-value:1.04E-12 ID:SGTC_2840|Compound:9008771|FD-Score:-5.02|P-value:4.22E-9 ID:SGTC_2881|Compound:9058953|FD-Score:-3.48|P-value:3.23E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.65|P-value:1.38E-5 ID:SGTC_2985|Compound:9022375|FD-Score:4.50|P-value:1.18E-7 ID:SGTC_3015|Compound:9080845|FD-Score:4.41|P-value:2.11E-7 ID:SGTC_3133|Compound:9127736|FD-Score:5.07|P-value:2.96E-9 ID:SGTC_3138|Compound:9097216|FD-Score:-5.92|P-value:5.50E-12 ID:SGTC_3141|Compound:9094609|FD-Score:5.39|P-value:3.14E-10 ID:SGTC_3207|Compound:9114163|FD-Score:2.94|P-value:3.76E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.51|P-value:2.76E-5 ID:SGTC_3329|Compound:9141233|FD-Score:2.96|P-value:3.42E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-4.16|P-value:9.05E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:2.75|P-value:7.94E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-5.53|P-value:1.13E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.99|P-value:4.97E-9 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.03|P-value:2.51E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.00|P-value:2.91E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.70|P-value:9.75E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.28|P-value:8.28E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:2.78|P-value:7.01E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.73|P-value:8.72E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.89|P-value:4.52E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.03|P-value:2.34E-12 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.96|P-value:3.46E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.79|P-value:1.50E-11 ID:SGTC_520|Compound:3584-0023|FD-Score:2.98|P-value:3.14E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:2.73|P-value:8.64E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-2.88|P-value:4.64E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.00|P-value:2.90E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.17|P-value:1.39E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.90|P-value:4.37E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:6.43|P-value:7.90E-14 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.40|P-value:4.82E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.49|P-value:1.26E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.64|P-value:1.45E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.87|P-value:4.38E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.86|P-value:5.24E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.04|P-value:2.45E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.35|P-value:6.10E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.82|P-value:6.11E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.17|P-value:1.41E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.76|P-value:7.92E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-4.06|P-value:1.59E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-3.16|P-value:1.42E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.75|P-value:7.88E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.96|P-value:2.68E-6 ID:SGTC_1927|Compound:st060202|FD-Score:3.73|P-value:9.56E-6 ID:SGTC_1936|Compound:st074407|FD-Score:3.08|P-value:2.04E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.39|P-value:5.09E-5 ID:SGTC_2037|Compound:5169046|FD-Score:6.01|P-value:2.66E-12 ID:SGTC_2051|Compound:5263410|FD-Score:2.76|P-value:7.84E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.53|P-value:2.51E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.01|P-value:2.81E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.39|P-value:5.05E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-2.92|P-value:4.03E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-2.93|P-value:3.77E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.27|P-value:8.77E-5 ID:SGTC_2413|Compound:inermin|FD-Score:6.06|P-value:1.78E-12 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.61|P-value:1.69E-14 ID:SGTC_2488|Compound:5268135|FD-Score:3.31|P-value:7.31E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.05|P-value:2.30E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.72|P-value:9.18E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.31|P-value:2.15E-13 ID:SGTC_2835|Compound:9006588|FD-Score:-5.05|P-value:3.28E-9 ID:SGTC_2837|Compound:9008476|FD-Score:6.12|P-value:1.04E-12 ID:SGTC_2840|Compound:9008771|FD-Score:-5.02|P-value:4.22E-9 ID:SGTC_2881|Compound:9058953|FD-Score:-3.48|P-value:3.23E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.65|P-value:1.38E-5 ID:SGTC_2985|Compound:9022375|FD-Score:4.50|P-value:1.18E-7 ID:SGTC_3015|Compound:9080845|FD-Score:4.41|P-value:2.11E-7 ID:SGTC_3133|Compound:9127736|FD-Score:5.07|P-value:2.96E-9 ID:SGTC_3138|Compound:9097216|FD-Score:-5.92|P-value:5.50E-12 ID:SGTC_3141|Compound:9094609|FD-Score:5.39|P-value:3.14E-10 ID:SGTC_3207|Compound:9114163|FD-Score:2.94|P-value:3.76E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.51|P-value:2.76E-5 ID:SGTC_3329|Compound:9141233|FD-Score:2.96|P-value:3.42E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-4.16|P-value:9.05E-7

Top fitness defect scores for YPL150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2418 pentamidine 6.61 31.7 µM 1.69E-14 mitochondrial processes 12 1.96E-11
2 SGTC_1186 1319-0216 6.43 26.0 µM 7.90E-14 2 6.34E-11
3 SGTC_2833 9001315 6.31 45.5 µM 2.15E-13 amide catabolism 14 1.36E-10
4 SGTC_2837 9008476 6.12 45.5 µM 1.04E-12 5 4.55E-10
5 SGTC_2413 inermin 6.06 26.1 µM 1.78E-12 17 6.82E-10
6 SGTC_453 enantio-paf c16 6.03 10.0 µM 2.34E-12 47 8.43E-10
7 SGTC_2037 5169046 6.01 200.0 µM 2.66E-12 60S ribosome export 1 9.30E-10
8 SGTC_514 4466-0038 5.79 2.6 nM 1.50E-11 cell wall 80 3.49E-9
9 SGTC_3141 9094609 5.39 49.5 µM 3.14E-10 iron homeostasis 12 3.56E-8
10 SGTC_3133 9127736 5.07 49.5 µM 2.96E-9 7 1.98E-7
11 SGTC_2985 9022375 4.50 71.4 µM 1.18E-7 RPP1 & pyrimidine depletion 19 3.33E-6
12 SGTC_1191 1487-1166 4.49 10.6 µM 1.26E-7 azole & statin 24 3.51E-6
13 SGTC_3015 9080845 4.41 49.5 µM 2.11E-7 4 5.20E-6
14 SGTC_1196 1588-0294 3.87 184.0 µM 4.38E-6 16 5.35E-5
15 SGTC_1725 st036284 3.76 20.6 µM 7.92E-6 30 8.43E-5
16 SGTC_1927 st060202 3.73 13.8 µM 9.56E-6 24 9.75E-5
17 SGTC_2907 7721985 3.65 69.9 µM 1.38E-5 31 1.30E-4
18 SGTC_1192 1488-0095 3.64 21.4 µM 1.45E-5 23 1.34E-4
19 SGTC_3284 9108171 3.51 64.9 µM 2.76E-5 37 2.21E-4
20 SGTC_2131 toluylene red 3.39 5.3 µM 5.05E-5 60S ribosome export 45 3.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.88E-25 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.160 1.43E-20 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.132 1.72E-14 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.128 1.11E-13 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.127 1.34E-13 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.125 3.13E-13 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.125 4.34E-13 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.117 8.95E-12 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.117 1.08E-11 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.113 6.40E-11 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.112 7.22E-11 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.112 7.28E-11 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.110 1.41E-10 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.106 8.97E-10 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.105 1.07E-9 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization