YPL162C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL162C / YPL162C

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.50|P-value:2.16E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.20|P-value:6.48E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.22|P-value:5.98E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.34|P-value:3.87E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.38|P-value:3.32E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.32|P-value:6.81E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:4.21|P-value:1.16E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.43|P-value:2.77E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.26|P-value:5.03E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-6.39|P-value:5.98E-11 ID:SGTC_855|Compound:0428-0020|FD-Score:4.43|P-value:4.09E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:5.23|P-value:6.93E-8 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.08|P-value:9.27E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.43|P-value:4.06E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.30|P-value:4.52E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.15|P-value:7.79E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.15|P-value:1.49E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.89|P-value:4.53E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.43|P-value:4.21E-6 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.76|P-value:8.26E-7 ID:SGTC_1653|Compound:st012112|FD-Score:-4.21|P-value:1.08E-5 ID:SGTC_1669|Compound:st015249|FD-Score:3.98|P-value:3.07E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.17|P-value:7.17E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.21|P-value:6.27E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.47|P-value:2.44E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-4.15|P-value:1.42E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.76|P-value:7.87E-5 ID:SGTC_2347|Compound:9049783|FD-Score:5.31|P-value:4.62E-8 ID:SGTC_2411|Compound:st077133|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.14|P-value:1.53E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.14|P-value:7.88E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.53|P-value:1.83E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.10|P-value:8.63E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.59|P-value:1.93E-6 ID:SGTC_2950|Compound:9072895|FD-Score:5.77|P-value:3.11E-9 ID:SGTC_2971|Compound:9092186|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.37|P-value:5.44E-6 ID:SGTC_3014|Compound:9081533|FD-Score:3.16|P-value:7.45E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.47|P-value:2.37E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.33|P-value:6.69E-6 ID:SGTC_3128|Compound:9127691|FD-Score:3.23|P-value:5.75E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.50|P-value:2.16E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.20|P-value:6.48E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.22|P-value:5.98E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.34|P-value:3.87E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.38|P-value:3.32E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.32|P-value:6.81E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:4.21|P-value:1.16E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.43|P-value:2.77E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.26|P-value:5.03E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-6.39|P-value:5.98E-11 ID:SGTC_855|Compound:0428-0020|FD-Score:4.43|P-value:4.09E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:5.23|P-value:6.93E-8 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.08|P-value:9.27E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.43|P-value:4.06E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.30|P-value:4.52E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.15|P-value:7.79E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.15|P-value:1.49E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.89|P-value:4.53E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.43|P-value:4.21E-6 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.76|P-value:8.26E-7 ID:SGTC_1653|Compound:st012112|FD-Score:-4.21|P-value:1.08E-5 ID:SGTC_1669|Compound:st015249|FD-Score:3.98|P-value:3.07E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.17|P-value:7.17E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.21|P-value:6.27E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.47|P-value:2.44E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-4.15|P-value:1.42E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.76|P-value:7.87E-5 ID:SGTC_2347|Compound:9049783|FD-Score:5.31|P-value:4.62E-8 ID:SGTC_2411|Compound:st077133|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.14|P-value:1.53E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.14|P-value:7.88E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.53|P-value:1.83E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.10|P-value:8.63E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.59|P-value:1.93E-6 ID:SGTC_2950|Compound:9072895|FD-Score:5.77|P-value:3.11E-9 ID:SGTC_2971|Compound:9092186|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.37|P-value:5.44E-6 ID:SGTC_3014|Compound:9081533|FD-Score:3.16|P-value:7.45E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.47|P-value:2.37E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.33|P-value:6.69E-6 ID:SGTC_3128|Compound:9127691|FD-Score:3.23|P-value:5.75E-4

Top fitness defect scores for YPL162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2950 9072895 5.77 21.5 µM 3.11E-9 10 3.89E-9
2 SGTC_2347 9049783 5.31 174.8 µM 4.62E-8 10 5.58E-8
3 SGTC_959 1222-0044 5.23 107.0 µM 6.93E-8 5 8.32E-8
4 SGTC_1410 3909-8106 4.76 77.9 µM 8.26E-7 6 9.59E-7
5 SGTC_2920 7982904 4.59 15.8 µM 1.93E-6 8 2.22E-6
6 SGTC_1126 isoteolin 4.43 1.0 µM 4.06E-6 18 4.62E-6
7 SGTC_855 0428-0020 4.43 25.0 µM 4.09E-6 Golgi 15 4.65E-6
8 SGTC_1399 3562-5772 4.43 25.0 µM 4.21E-6 RPP1 & pyrimidine depletion 10 4.79E-6
9 SGTC_3011 9081274 4.37 71.4 µM 5.44E-6 7 6.17E-6
10 SGTC_3123 9126162 4.33 49.5 µM 6.69E-6 13 7.56E-6
11 SGTC_523 1934-0222 4.32 13.7 µM 6.81E-6 27 7.70E-6
12 SGTC_541 4513-1321 4.21 94.0 µM 1.16E-5 17 1.30E-5
13 SGTC_1388 3346-4487 4.15 254.0 µM 1.49E-5 20 1.67E-5
14 SGTC_2639 lactacystin 4.14 53.0 µM 1.53E-5 17 1.71E-5
15 SGTC_1669 st015249 3.98 58.4 µM 3.07E-5 Golgi 7 3.41E-5
16 SGTC_1396 3511-0007 3.89 98.6 µM 4.53E-5 mitochondrial processes 11 5.00E-5
17 SGTC_2128 5255449 3.76 168.5 µM 7.87E-5 41 8.61E-5
18 SGTC_20 0481-0013 3.50 4.9 µM 2.16E-4 41 2.33E-4
19 SGTC_3025 9087895 3.47 49.5 µM 2.37E-4 PDR1 52 2.56E-4
20 SGTC_1913 st060213 3.47 96.1 µM 2.44E-4 51 2.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.84E-13 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.123 8.49E-13 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.105 9.93E-10 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.104 1.77E-9 YMR313C TGL3 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation
0.088 3.22E-7 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.084 1.27E-6 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.081 2.49E-6 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.079 4.18E-6 YDR361C BCP1 het Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
0.079 4.22E-6 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.079 4.38E-6 YDR111C_p ALT2_p hom Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p
0.077 7.72E-6 YLR286C CTS1 hom Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
0.077 8.51E-6 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 1.07E-5 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.076 1.19E-5 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.074 1.70E-5 YMR125W STO1 hom Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80