YPL163C / SVS1

Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL163C / SVS1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-2.80|P-value:7.73E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.10|P-value:4.32E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:2.95|P-value:7.74E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.02|P-value:3.27E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.04|P-value:5.46E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.20|P-value:1.60E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.02|P-value:6.01E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.03|P-value:3.12E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.24|P-value:2.44E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.63|P-value:2.68E-7 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.32|P-value:9.41E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.40|P-value:9.61E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:-2.99|P-value:3.68E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.20|P-value:2.90E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.50|P-value:4.09E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:2.30E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.98|P-value:7.05E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.12|P-value:4.03E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.45|P-value:1.02E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.08|P-value:4.76E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.18|P-value:3.22E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.00|P-value:3.06E-8 ID:SGTC_1770|Compound:st043884|FD-Score:3.77|P-value:2.37E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.93|P-value:1.10E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.64|P-value:2.14E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-4.74|P-value:5.67E-8 ID:SGTC_1984|Compound:st072354|FD-Score:3.06|P-value:5.12E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.10|P-value:4.38E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.97|P-value:9.03E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.40|P-value:1.24E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-2.77|P-value:8.73E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.14|P-value:3.69E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-2.74|P-value:9.60E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-2.83|P-value:6.94E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.03|P-value:6.67E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.04|P-value:5.59E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.86|P-value:7.30E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-5.51|P-value:3.87E-10 ID:SGTC_2835|Compound:9006588|FD-Score:-7.68|P-value:7.17E-18 ID:SGTC_2837|Compound:9008476|FD-Score:5.47|P-value:1.50E-9 ID:SGTC_2967|Compound:9089538|FD-Score:3.20|P-value:2.96E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.31|P-value:1.86E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-2.92|P-value:4.90E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.66|P-value:1.98E-5 ID:SGTC_3083|Compound:9117465|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.00|P-value:6.36E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.67|P-value:3.72E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.84|P-value:1.71E-5 ID:SGTC_3158|Compound:9100007|FD-Score:4.69|P-value:1.85E-7 ID:SGTC_3181|Compound:9108277|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.90|P-value:6.20E-6 ID:SGTC_3346|Compound:9158254|FD-Score:-3.31|P-value:9.76E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-2.80|P-value:7.73E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.10|P-value:4.32E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:2.95|P-value:7.74E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.02|P-value:3.27E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.04|P-value:5.46E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.20|P-value:1.60E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.02|P-value:6.01E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.03|P-value:3.12E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.24|P-value:2.44E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.63|P-value:2.68E-7 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.32|P-value:9.41E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.40|P-value:9.61E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:-2.99|P-value:3.68E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.20|P-value:2.90E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.50|P-value:4.09E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:2.30E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.98|P-value:7.05E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.12|P-value:4.03E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.45|P-value:1.02E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.08|P-value:4.76E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.18|P-value:3.22E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.00|P-value:3.06E-8 ID:SGTC_1770|Compound:st043884|FD-Score:3.77|P-value:2.37E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.93|P-value:1.10E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.64|P-value:2.14E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-4.74|P-value:5.67E-8 ID:SGTC_1984|Compound:st072354|FD-Score:3.06|P-value:5.12E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.10|P-value:4.38E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.97|P-value:9.03E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.40|P-value:1.24E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-2.77|P-value:8.73E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.14|P-value:3.69E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-2.74|P-value:9.60E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-2.83|P-value:6.94E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.03|P-value:6.67E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.04|P-value:5.59E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.86|P-value:7.30E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-5.51|P-value:3.87E-10 ID:SGTC_2835|Compound:9006588|FD-Score:-7.68|P-value:7.17E-18 ID:SGTC_2837|Compound:9008476|FD-Score:5.47|P-value:1.50E-9 ID:SGTC_2967|Compound:9089538|FD-Score:3.20|P-value:2.96E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.31|P-value:1.86E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-2.92|P-value:4.90E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.66|P-value:1.98E-5 ID:SGTC_3083|Compound:9117465|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.00|P-value:6.36E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.67|P-value:3.72E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.84|P-value:1.71E-5 ID:SGTC_3158|Compound:9100007|FD-Score:4.69|P-value:1.85E-7 ID:SGTC_3181|Compound:9108277|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.90|P-value:6.20E-6 ID:SGTC_3346|Compound:9158254|FD-Score:-3.31|P-value:9.76E-5

Top fitness defect scores for YPL163C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2837 9008476 5.47 45.5 µM 1.50E-9 10 2.31E-8
2 SGTC_1725 st036284 5.00 20.6 µM 3.06E-8 12 2.93E-7
3 SGTC_3158 9100007 4.69 49.5 µM 1.85E-7 10 1.34E-6
4 SGTC_925 2064-1272 4.63 59.6 µM 2.68E-7 12 1.83E-6
5 SGTC_1081 sertraline 4.40 6.0 µM 9.61E-7 60S ribosome export 23 5.38E-6
6 SGTC_2611 pyromycin 4.03 23.9 µM 6.67E-6 27 2.77E-5
7 SGTC_2210 7115885 3.97 190.4 µM 9.03E-6 cell wall signaling 32 3.58E-5
8 SGTC_1776 st049249 3.93 45.9 µM 1.10E-5 16 4.23E-5
9 SGTC_3157 9099274 3.84 49.5 µM 1.71E-5 24 6.16E-5
10 SGTC_1164 k060-0068 3.78 93.7 µM 2.30E-5 34 7.91E-5
11 SGTC_1770 st043884 3.77 66.3 µM 2.37E-5 14 8.13E-5
12 SGTC_3153 9100258 3.67 49.5 µM 3.72E-5 31 1.19E-4
13 SGTC_1677 st019204 3.45 53.9 µM 1.02E-4 34 2.81E-4
14 SGTC_1925 st057770 3.44 10.1 µM 1.06E-4 TSC3-RPN4 32 2.90E-4
15 SGTC_2252 omeprazole 3.40 400.0 µM 1.24E-4 16 3.32E-4
16 SGTC_156 3474-0145 3.39 5.6 µM 1.31E-4 endomembrane recycling 74 3.48E-4
17 SGTC_1074 carmofur 3.36 3.8 µM 1.50E-4 exosome 48 3.91E-4
18 SGTC_3021 9087658 3.31 49.5 µM 1.86E-4 13 4.69E-4
19 SGTC_1062 mesoridazine 3.29 14.2 µM 1.99E-4 35 4.96E-4
20 SGTC_912 3474-0017 3.24 2.2 µM 2.44E-4 48 5.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.73E-21 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.128 1.11E-13 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.092 9.72E-8 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.84E-7 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.087 4.78E-7 YPL009C TAE2 hom Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.085 9.56E-7 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.084 1.17E-6 YPR193C HPA2 hom Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.083 1.39E-6 YDR184C ATC1 hom Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress
0.082 1.86E-6 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.081 2.71E-6 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.080 3.13E-6 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.078 6.87E-6 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.077 9.03E-6 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.076 1.17E-5 YDL068W_d YDL068W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.074 2.01E-5 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm