YPL167C / REV3

Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL167C / REV3

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-3.39|P-value:5.48E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.30|P-value:6.79E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.65|P-value:1.98E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.51|P-value:3.20E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.38|P-value:1.07E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.23|P-value:9.26E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.78|P-value:1.23E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.32|P-value:6.23E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:4.10|P-value:3.42E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.10|P-value:3.45E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.60|P-value:4.49E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.04|P-value:4.38E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.33|P-value:6.06E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.37|P-value:5.23E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.19|P-value:9.60E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.20|P-value:2.30E-7 ID:SGTC_1741|Compound:st038134|FD-Score:-4.57|P-value:5.10E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-4.12|P-value:3.49E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.83|P-value:9.80E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.30|P-value:1.50E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.40|P-value:5.33E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.47|P-value:3.72E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.78|P-value:1.33E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.70|P-value:1.83E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-4.50|P-value:7.23E-6 ID:SGTC_2231|Compound:micatex|FD-Score:3.91|P-value:7.23E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.54|P-value:2.95E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.27|P-value:8.04E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.25|P-value:1.82E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.48|P-value:3.61E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.52|P-value:3.09E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.57|P-value:2.66E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.23|P-value:9.33E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.43|P-value:4.67E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.29|P-value:1.56E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.96|P-value:6.08E-5 ID:SGTC_2931|Compound:9014674|FD-Score:3.46|P-value:3.81E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.26|P-value:1.78E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.48|P-value:3.56E-4 ID:SGTC_3007|Compound:9078383|FD-Score:5.01|P-value:5.89E-7 ID:SGTC_3072|Compound:9116419|FD-Score:5.77|P-value:1.09E-8 ID:SGTC_3143|Compound:9086658|FD-Score:-4.50|P-value:7.05E-6 ID:SGTC_3168|Compound:9103419|FD-Score:-3.31|P-value:7.20E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.73|P-value:1.48E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.19|P-value:9.67E-4 ID:SGTC_3212|Compound:9128307|FD-Score:14.90|P-value:2.60E-47 ID:SGTC_3214|Compound:9129694|FD-Score:-3.21|P-value:9.84E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.45|P-value:3.96E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.39|P-value:5.48E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.30|P-value:6.79E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.65|P-value:1.98E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.51|P-value:3.20E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.38|P-value:1.07E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.23|P-value:9.26E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.78|P-value:1.23E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.32|P-value:6.23E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:4.10|P-value:3.42E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.10|P-value:3.45E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.60|P-value:4.49E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.04|P-value:4.38E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.33|P-value:6.06E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.37|P-value:5.23E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.19|P-value:9.60E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.20|P-value:2.30E-7 ID:SGTC_1741|Compound:st038134|FD-Score:-4.57|P-value:5.10E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-4.12|P-value:3.49E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.83|P-value:9.80E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.30|P-value:1.50E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.40|P-value:5.33E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.47|P-value:3.72E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.78|P-value:1.33E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.70|P-value:1.83E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-4.50|P-value:7.23E-6 ID:SGTC_2231|Compound:micatex|FD-Score:3.91|P-value:7.23E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.54|P-value:2.95E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.27|P-value:8.04E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.25|P-value:1.82E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.48|P-value:3.61E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.52|P-value:3.09E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.57|P-value:2.66E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.23|P-value:9.33E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.43|P-value:4.67E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.29|P-value:1.56E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.96|P-value:6.08E-5 ID:SGTC_2931|Compound:9014674|FD-Score:3.46|P-value:3.81E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.26|P-value:1.78E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.48|P-value:3.56E-4 ID:SGTC_3007|Compound:9078383|FD-Score:5.01|P-value:5.89E-7 ID:SGTC_3072|Compound:9116419|FD-Score:5.77|P-value:1.09E-8 ID:SGTC_3143|Compound:9086658|FD-Score:-4.50|P-value:7.05E-6 ID:SGTC_3168|Compound:9103419|FD-Score:-3.31|P-value:7.20E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.73|P-value:1.48E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.19|P-value:9.67E-4 ID:SGTC_3212|Compound:9128307|FD-Score:14.90|P-value:2.60E-47 ID:SGTC_3214|Compound:9129694|FD-Score:-3.21|P-value:9.84E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.45|P-value:3.96E-4

Top fitness defect scores for YPL167C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3212 9128307 14.90 49.5 µM 2.60E-47 1 2.70E-50
2 SGTC_3072 9116419 5.77 49.5 µM 1.09E-8 ERG2 1 3.94E-9
3 SGTC_1479 0549-0158 5.20 134.0 µM 2.30E-7 8 1.01E-7
4 SGTC_3007 9078383 5.01 71.4 µM 5.89E-7 4 2.75E-7
5 SGTC_541 4513-1321 4.38 94.0 µM 1.07E-5 15 6.01E-6
6 SGTC_1958 st076513 4.30 41.9 µM 1.50E-5 60S ribosome export 20 8.55E-6
7 SGTC_2803 7707263 4.29 71.4 µM 1.56E-5 25 8.93E-6
8 SGTC_2962 9082311 4.26 13.2 µM 1.78E-5 13 1.03E-5
9 SGTC_2313 7726885 4.25 200.0 µM 1.82E-5 RPP1 & pyrimidine depletion 28 1.06E-5
10 SGTC_807 1315-0151 4.10 48.0 µM 3.42E-5 24 2.06E-5
11 SGTC_1066 ketoconazole 4.10 628.0 nM 3.45E-5 16 2.07E-5
12 SGTC_1144 3486-0183 4.04 12.5 µM 4.38E-5 24 2.67E-5
13 SGTC_2860 9025725 3.96 39.0 µM 6.08E-5 RPP1 & pyrimidine depletion 9 3.79E-5
14 SGTC_2231 micatex 3.91 6.8 µM 7.23E-5 18 4.55E-5
15 SGTC_1836 st055642 3.83 81.0 µM 9.80E-5 18 6.29E-5
16 SGTC_654 1124-0271 3.78 80.9 µM 1.23E-4 26 8.00E-5
17 SGTC_3199 9111318 3.73 49.5 µM 1.48E-4 28 9.70E-5
18 SGTC_247 mechlorethamine 3.65 29.7 µM 1.98E-4 DNA damage response 22 1.32E-4
19 SGTC_2544 sphondin 3.57 68.5 µM 2.66E-4 RNA pol III & RNase P/MRP 35 1.81E-4
20 SGTC_2236 dapsone 3.54 200.0 µM 2.95E-4 17 2.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 2.56E-41 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.173 6.80E-24 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.151 1.22E-18 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 9.94E-16 YJR107W_p YJR107W_p hom Putative lipase
0.130 4.10E-14 YLR116W MSL5 het Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
0.112 7.79E-11 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
0.112 8.24E-11 YLR312W-A MRPL15 hom Mitochondrial ribosomal protein of the large subunit
0.106 7.20E-10 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.104 1.48E-9 YNR074C AIF1 hom Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
0.103 2.05E-9 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.102 3.34E-9 YFR032C_p RRT5_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
0.102 3.42E-9 YOR034C AKR2 hom Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication
0.100 6.50E-9 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.099 8.17E-9 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.099 8.43E-9 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication