YPL171C / OYE3

Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL171C / OYE3

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.77|P-value:1.29E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.66|P-value:1.69E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.86|P-value:8.06E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.81|P-value:9.74E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.61|P-value:2.40E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.39|P-value:4.56E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.75|P-value:1.24E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.57|P-value:2.38E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:6.18|P-value:7.98E-10 ID:SGTC_925|Compound:2064-1272|FD-Score:4.10|P-value:3.06E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.27|P-value:6.91E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.63|P-value:1.91E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.01|P-value:4.41E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.79|P-value:1.20E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.86|P-value:1.04E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.65|P-value:1.80E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.50|P-value:3.48E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-5.51|P-value:4.62E-8 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.23|P-value:7.96E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.49|P-value:3.17E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.39|P-value:8.92E-6 ID:SGTC_2026|Compound:5148700|FD-Score:5.46|P-value:4.83E-8 ID:SGTC_2041|Compound:5107442|FD-Score:-4.73|P-value:2.29E-6 ID:SGTC_2164|Compound:5685496|FD-Score:4.09|P-value:3.26E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.42|P-value:4.11E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.70|P-value:1.70E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.14|P-value:2.58E-7 ID:SGTC_2398|Compound:5228213|FD-Score:3.43|P-value:3.93E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.79|P-value:1.69E-6 ID:SGTC_2401|Compound:5128683|FD-Score:6.39|P-value:2.21E-10 ID:SGTC_2403|Compound:6032726|FD-Score:3.19|P-value:8.93E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.96|P-value:5.32E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.30|P-value:1.32E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.10|P-value:3.13E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.47|P-value:3.97E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.42|P-value:4.07E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.01|P-value:5.09E-5 ID:SGTC_3130|Compound:9127414|FD-Score:6.41|P-value:2.04E-10 ID:SGTC_3196|Compound:9111891|FD-Score:3.24|P-value:7.63E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.77|P-value:1.29E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.66|P-value:1.69E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.86|P-value:8.06E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.81|P-value:9.74E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.61|P-value:2.40E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.39|P-value:4.56E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.75|P-value:1.24E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.57|P-value:2.38E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:6.18|P-value:7.98E-10 ID:SGTC_925|Compound:2064-1272|FD-Score:4.10|P-value:3.06E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.27|P-value:6.91E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.63|P-value:1.91E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.01|P-value:4.41E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.79|P-value:1.20E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.86|P-value:1.04E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.65|P-value:1.80E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.50|P-value:3.48E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-5.51|P-value:4.62E-8 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.23|P-value:7.96E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.49|P-value:3.17E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.39|P-value:8.92E-6 ID:SGTC_2026|Compound:5148700|FD-Score:5.46|P-value:4.83E-8 ID:SGTC_2041|Compound:5107442|FD-Score:-4.73|P-value:2.29E-6 ID:SGTC_2164|Compound:5685496|FD-Score:4.09|P-value:3.26E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.42|P-value:4.11E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.70|P-value:1.70E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.14|P-value:2.58E-7 ID:SGTC_2398|Compound:5228213|FD-Score:3.43|P-value:3.93E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.79|P-value:1.69E-6 ID:SGTC_2401|Compound:5128683|FD-Score:6.39|P-value:2.21E-10 ID:SGTC_2403|Compound:6032726|FD-Score:3.19|P-value:8.93E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.96|P-value:5.32E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.30|P-value:1.32E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.10|P-value:3.13E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.47|P-value:3.97E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.42|P-value:4.07E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.01|P-value:5.09E-5 ID:SGTC_3130|Compound:9127414|FD-Score:6.41|P-value:2.04E-10 ID:SGTC_3196|Compound:9111891|FD-Score:3.24|P-value:7.63E-4

Top fitness defect scores for YPL171C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3130 9127414 6.41 49.5 µM 2.04E-10 4 7.48E-11
2 SGTC_2401 5128683 6.39 200.0 µM 2.21E-10 8 8.12E-11
3 SGTC_757 1066-0008 6.18 322.0 µM 7.98E-10 Golgi 3 3.13E-10
4 SGTC_2026 5148700 5.46 152.0 µM 4.83E-8 6 2.35E-8
5 SGTC_2397 5161689 5.14 200.0 µM 2.58E-7 12 1.36E-7
6 SGTC_1237 0330-0133 4.86 46.1 µM 1.04E-6 ergosterol biosynthesis 15 5.91E-7
7 SGTC_1993 st073995 4.39 70.8 µM 8.92E-6 14 5.64E-6
8 SGTC_2497 7-hydroxyflavone 4.30 100.0 µM 1.32E-5 17 8.54E-6
9 SGTC_925 2064-1272 4.10 59.6 µM 3.06E-5 20 2.06E-5
10 SGTC_2541 muurolladie-3-one 4.10 83.1 µM 3.13E-5 excess fatty acid 24 2.11E-5
11 SGTC_2164 5685496 4.09 200.0 µM 3.26E-5 22 2.20E-5
12 SGTC_966 1300-0360 4.01 30.2 µM 4.41E-5 heme requiring 22 3.02E-5
13 SGTC_2415 st077333 3.96 57.7 µM 5.32E-5 45 3.68E-5
14 SGTC_375 3970-0961 3.86 9.3 µM 8.06E-5 tubulin folding & SWR complex 21 5.68E-5
15 SGTC_405 ebelactone b 3.81 50.0 µM 9.74E-5 21 6.93E-5
16 SGTC_754 3474-0146 3.75 171.0 µM 1.24E-4 copper-dependent oxidative stress 29 8.94E-5
17 SGTC_229 benomyl 3.66 22.9 µM 1.69E-4 tubulin folding & SWR complex 38 1.24E-4
18 SGTC_1692 fluoroquinolonic acid 3.65 71.0 µM 1.78E-4 8 1.31E-4
19 SGTC_1249 0481-0015 3.65 10.2 µM 1.80E-4 33 1.32E-4
20 SGTC_937 3122-0005 3.63 46.7 µM 1.91E-4 33 1.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.99E-12 YNL202W SPS19 hom Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
0.096 2.36E-8 YOR265W RBL2 hom Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress
0.095 4.11E-8 YDR079C-A TFB5 hom Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
0.084 9.73E-7 YJR010C-A SPC1 hom Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
0.081 2.60E-6 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.078 5.38E-6 YLR399C BDF1 hom Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
0.077 7.08E-6 YLR046C_p YLR046C_p hom Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.077 8.08E-6 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.076 1.05E-5 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.076 1.08E-5 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.072 2.89E-5 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.072 3.08E-5 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.072 3.30E-5 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.071 3.52E-5 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.068 7.29E-5 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2