YPL189C-A / COA2

Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL189C-A / COA2

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:5.26|P-value:2.60E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.19|P-value:6.32E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:12.00|P-value:1.24E-35 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.68|P-value:6.28E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:12.20|P-value:3.15E-37 ID:SGTC_398|Compound:bronopol|FD-Score:-4.02|P-value:1.41E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.14|P-value:5.93E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.29|P-value:3.09E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.20|P-value:4.67E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.26|P-value:3.38E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.62|P-value:9.03E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.74|P-value:4.82E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.53|P-value:1.19E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.07|P-value:6.95E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.16|P-value:4.94E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.58|P-value:9.61E-7 ID:SGTC_929|Compound:2805-0021|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.89|P-value:2.55E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.80|P-value:3.74E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.77|P-value:3.51E-7 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.53|P-value:1.18E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.16|P-value:5.51E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.49|P-value:1.38E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.29|P-value:3.08E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.26|P-value:3.68E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-2.99|P-value:9.14E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.26|P-value:3.69E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.57|P-value:9.89E-5 ID:SGTC_1554|Compound:st069299|FD-Score:-3.10|P-value:6.20E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.58|P-value:9.60E-7 ID:SGTC_1633|Compound:st005664|FD-Score:-5.00|P-value:9.79E-8 ID:SGTC_1635|Compound:st007035|FD-Score:21.30|P-value:4.87E-108 ID:SGTC_1638|Compound:st008370|FD-Score:-3.67|P-value:6.69E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.79|P-value:8.11E-13 ID:SGTC_1989|Compound:st071868|FD-Score:4.27|P-value:4.84E-6 ID:SGTC_2018|Compound:5133068|FD-Score:3.80|P-value:4.12E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.85|P-value:3.07E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-3.29|P-value:3.02E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.79|P-value:4.05E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.30|P-value:2.92E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-2.98|P-value:9.40E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.63|P-value:8.82E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.81|P-value:3.99E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.26|P-value:3.75E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-3.78|P-value:4.13E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.08|P-value:6.54E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.83|P-value:3.74E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.22|P-value:3.91E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-4.85|P-value:2.28E-7 ID:SGTC_3283|Compound:9109332|FD-Score:-3.89|P-value:2.61E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.39|P-value:2.76E-6 ID:SGTC_3351|Compound:9150312|FD-Score:-3.91|P-value:2.39E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.26|P-value:2.60E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.19|P-value:6.32E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:12.00|P-value:1.24E-35 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.68|P-value:6.28E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:12.20|P-value:3.15E-37 ID:SGTC_398|Compound:bronopol|FD-Score:-4.02|P-value:1.41E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.14|P-value:5.93E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.29|P-value:3.09E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.20|P-value:4.67E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.26|P-value:3.38E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.62|P-value:9.03E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.74|P-value:4.82E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.53|P-value:1.19E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.07|P-value:6.95E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.16|P-value:4.94E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.58|P-value:9.61E-7 ID:SGTC_929|Compound:2805-0021|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.89|P-value:2.55E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.80|P-value:3.74E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.77|P-value:3.51E-7 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.53|P-value:1.18E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.16|P-value:5.51E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.49|P-value:1.38E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.29|P-value:3.08E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.26|P-value:3.68E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-2.99|P-value:9.14E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.26|P-value:3.69E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.57|P-value:9.89E-5 ID:SGTC_1554|Compound:st069299|FD-Score:-3.10|P-value:6.20E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.58|P-value:9.60E-7 ID:SGTC_1633|Compound:st005664|FD-Score:-5.00|P-value:9.79E-8 ID:SGTC_1635|Compound:st007035|FD-Score:21.30|P-value:4.87E-108 ID:SGTC_1638|Compound:st008370|FD-Score:-3.67|P-value:6.69E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.79|P-value:8.11E-13 ID:SGTC_1989|Compound:st071868|FD-Score:4.27|P-value:4.84E-6 ID:SGTC_2018|Compound:5133068|FD-Score:3.80|P-value:4.12E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.85|P-value:3.07E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-3.29|P-value:3.02E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.79|P-value:4.05E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.30|P-value:2.92E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-2.98|P-value:9.40E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.63|P-value:8.82E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.81|P-value:3.99E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.26|P-value:3.75E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-3.78|P-value:4.13E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.08|P-value:6.54E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.83|P-value:3.74E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.22|P-value:3.91E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-4.85|P-value:2.28E-7 ID:SGTC_3283|Compound:9109332|FD-Score:-3.89|P-value:2.61E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.39|P-value:2.76E-6 ID:SGTC_3351|Compound:9150312|FD-Score:-3.91|P-value:2.39E-5

Top fitness defect scores for YPL189C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 21.30 42.4 µM 4.87E-108 20 1.54E-100
2 SGTC_386 1509-0011 12.20 3.1 µM 3.15E-37 33 9.30E-35
3 SGTC_236 1509-0011 12.00 5.3 µM 1.24E-35 151 2.82E-33
4 SGTC_134 0269-0018 5.26 6.9 µM 2.60E-8 95 7.33E-8
5 SGTC_3342 9147791 4.39 14.5 µM 2.76E-6 9 5.68E-6
6 SGTC_1989 st071868 4.27 50.2 µM 4.84E-6 7 9.60E-6
7 SGTC_3064 1327-0027 3.83 10.0 µM 3.74E-5 10 6.48E-5
8 SGTC_3045 9092950 3.81 49.5 µM 3.99E-5 20 6.88E-5
9 SGTC_2018 5133068 3.80 143.0 µM 4.12E-5 26 7.09E-5
10 SGTC_2852 9023854 3.63 52.0 µM 8.82E-5 39 1.44E-4
11 SGTC_740 k014-0057 3.62 261.0 µM 9.03E-5 37 1.48E-4
12 SGTC_1060 3448-7350 3.44 82.0 µM 1.88E-4 Golgi 48 2.93E-4
13 SGTC_3336 9143619 3.29 71.4 µM 3.32E-4 43 4.99E-4
14 SGTC_1312 1218-2183 3.26 165.0 µM 3.68E-4 17 5.50E-4
15 SGTC_1319 1306-0155 3.26 43.7 µM 3.69E-4 63 5.50E-4
16 SGTC_3048 9093155 3.26 49.5 µM 3.75E-4 16 5.59E-4
17 SGTC_929 2805-0021 3.22 398.0 µM 4.39E-4 34 6.49E-4
18 SGTC_621 3584-0052 3.20 32.1 µM 4.67E-4 46 6.87E-4
19 SGTC_1214 0358-0031 3.16 63.7 µM 5.51E-4 47 8.01E-4
20 SGTC_604 1000-0114 3.14 314.0 µM 5.93E-4 59 8.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.691 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.662 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.624 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.621 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.599 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.589 4.52E-312 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.573 1.83E-292 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.572 3.98E-291 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.559 1.40E-275 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.556 2.13E-271 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.543 6.72E-257 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.542 1.68E-255 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.540 7.30E-254 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.538 4.11E-251 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.536 6.72E-249 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain