HIPHOP chemogenomics database

YPL201C / YIG1

Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL201C / YIG1

Click on Significant Values for Screen Details

Top fitness defect scores for YPL201C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2283	7944793	6.96	200.0 µM	3.76E-12		3	1.65E-12
2	SGTC_2924	9010168	6.96	62.8 µM	3.85E-12	cell wall signaling	6	1.69E-12
3	SGTC_1829	berberine	5.70	14.4 µM	1.06E-8	60S ribosome export	4	6.14E-9
4	SGTC_870	0573-2213	5.50	57.6 µM	3.13E-8	ERG2	4	1.87E-8
5	SGTC_1241	0364-0022	5.31	50.8 µM	8.89E-8	ERG2	10	5.52E-8
6	SGTC_2014	4013930	5.29	200.0 µM	9.59E-8		5	5.97E-8
7	SGTC_2276	7947513	4.84	42.1 µM	9.73E-7		13	6.55E-7
8	SGTC_3198	9112019	4.68	49.5 µM	2.08E-6	mitochondrial processes	6	1.44E-6
9	SGTC_1592	4',5'-dihydroxyflavone	4.55	8.8 µM	3.78E-6	60S ribosome export	5	2.66E-6
10	SGTC_152	4469-0003	4.46	551.2 µM	5.76E-6		15	4.12E-6
11	SGTC_93	0109-0045	4.38	59.2 µM	8.14E-6	DNA damage response	27	5.88E-6
12	SGTC_933	2914-0560	4.21	114.0 µM	1.70E-5		21	1.26E-5
13	SGTC_334	1502-1024	4.17	68.5 µM	2.03E-5		8	1.52E-5
14	SGTC_2365	9042475	4.14	200.0 µM	2.33E-5		29	1.74E-5
15	SGTC_3036	9090181	4.10	49.5 µM	2.70E-5		6	2.03E-5
16	SGTC_402	epigallocatechin gallate	4.04	10.0 µM	3.45E-5		22	2.62E-5
17	SGTC_1793	st048256	4.02	72.2 µM	3.85E-5		3	2.93E-5
18	SGTC_2357	9067248	3.89	200.0 µM	6.46E-5		17	5.00E-5
19	SGTC_681	1642-0006	3.84	26.6 µM	7.97E-5		6	6.21E-5
20	SGTC_1970	st070122	3.81	35.8 µM	8.87E-5	TSC3-RPN4	29	6.94E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.104	1.80E-9	YER152C	YER152C	hom	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.095	4.15E-8	YOR311C	DGK1	hom	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.083	1.57E-6	YOR131C	YOR131C	hom	Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.074	1.66E-5	YGR242W_d	YGR242W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.074	1.75E-5	YGR071C	ENV11	hom	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.074	1.98E-5	YLR097C	HRT3	hom	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.073	2.62E-5	YPL064C	CWC27	hom	Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.072	3.05E-5	YMR246W	FAA4	hom	Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
0.068	8.94E-5	YOL160W_d	YOL160W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.067	9.40E-5	YBL073W_d	YBL073W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C
0.067	1.04E-4	YLR409C	UTP21	het	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
0.066	1.37E-4	YPR114W_p	YPR114W_p	hom	Putative protein of unknown function
0.065	1.50E-4	YPR161C	SGV1	het	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
0.065	1.71E-4	YKR048C	NAP1	hom	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
0.064	1.90E-4	YDR020C_p	DAS2_p	hom	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases