YPL204W / HRR25

Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL204W / HRR25

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.70|P-value:2.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.43|P-value:6.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:5.66|P-value:4.86E-8 ID:SGTC_44|Compound:0929-0055|FD-Score:6.44|P-value:6.21E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:3.95|P-value:9.86E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-9.10|P-value:5.39E-18 ID:SGTC_173|Compound:1273-0061|FD-Score:12.30|P-value:3.33E-31 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.99|P-value:1.38E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:4.24|P-value:3.19E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.57|P-value:3.73E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.63|P-value:6.23E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:3.75|P-value:2.05E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.62|P-value:3.14E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.38|P-value:7.10E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.50|P-value:4.86E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.85|P-value:1.41E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.50|P-value:4.73E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-5.74|P-value:3.40E-8 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.50|P-value:1.08E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.50|P-value:4.74E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.78|P-value:1.92E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.45|P-value:1.35E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.68|P-value:2.74E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.81|P-value:1.72E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.75|P-value:2.01E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-5.13|P-value:7.13E-7 ID:SGTC_1519|Compound:esterone|FD-Score:-3.58|P-value:3.89E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.23|P-value:3.32E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.71|P-value:2.47E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.80|P-value:1.70E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-4.69|P-value:5.14E-6 ID:SGTC_1620|Compound:st003704|FD-Score:3.40|P-value:6.67E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.99|P-value:8.34E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.50|P-value:4.96E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.69|P-value:4.86E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.37|P-value:7.30E-4 ID:SGTC_2122|Compound:5258151|FD-Score:9.09|P-value:5.28E-18 ID:SGTC_2124|Compound:5246320|FD-Score:5.78|P-value:2.59E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.67|P-value:2.66E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.67|P-value:5.76E-6 ID:SGTC_2291|Compound:7917025|FD-Score:5.00|P-value:1.24E-6 ID:SGTC_2351|Compound:9026858|FD-Score:4.25|P-value:3.11E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.70|P-value:5.03E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.07|P-value:5.33E-9 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.29|P-value:2.60E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-6.15|P-value:3.74E-9 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.31|P-value:9.29E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.22|P-value:3.62E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.72|P-value:3.45E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:4.20|P-value:3.75E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.32|P-value:8.56E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.51|P-value:4.92E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.30|P-value:9.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-5.27|P-value:3.61E-7 ID:SGTC_2803|Compound:7707263|FD-Score:-4.34|P-value:2.29E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.38|P-value:7.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:5.80|P-value:2.33E-8 ID:SGTC_2928|Compound:9011484|FD-Score:3.67|P-value:2.70E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.04|P-value:7.40E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.92|P-value:1.15E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.97|P-value:9.03E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.37|P-value:7.80E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.64|P-value:6.08E-6 ID:SGTC_3199|Compound:9111318|FD-Score:5.94|P-value:1.07E-8 ID:SGTC_13|Compound:0199-0087|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.70|P-value:2.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.43|P-value:6.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:5.66|P-value:4.86E-8 ID:SGTC_44|Compound:0929-0055|FD-Score:6.44|P-value:6.21E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:3.95|P-value:9.86E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-9.10|P-value:5.39E-18 ID:SGTC_173|Compound:1273-0061|FD-Score:12.30|P-value:3.33E-31 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.99|P-value:1.38E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:4.24|P-value:3.19E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.57|P-value:3.73E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.63|P-value:6.23E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:3.75|P-value:2.05E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.62|P-value:3.14E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.38|P-value:7.10E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.50|P-value:4.86E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.85|P-value:1.41E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.50|P-value:4.73E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-5.74|P-value:3.40E-8 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.50|P-value:1.08E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.50|P-value:4.74E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.78|P-value:1.92E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.45|P-value:1.35E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.68|P-value:2.74E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.81|P-value:1.72E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.75|P-value:2.01E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-5.13|P-value:7.13E-7 ID:SGTC_1519|Compound:esterone|FD-Score:-3.58|P-value:3.89E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.23|P-value:3.32E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.71|P-value:2.47E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.80|P-value:1.70E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-4.69|P-value:5.14E-6 ID:SGTC_1620|Compound:st003704|FD-Score:3.40|P-value:6.67E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.99|P-value:8.34E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.50|P-value:4.96E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.69|P-value:4.86E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.37|P-value:7.30E-4 ID:SGTC_2122|Compound:5258151|FD-Score:9.09|P-value:5.28E-18 ID:SGTC_2124|Compound:5246320|FD-Score:5.78|P-value:2.59E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.67|P-value:2.66E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.67|P-value:5.76E-6 ID:SGTC_2291|Compound:7917025|FD-Score:5.00|P-value:1.24E-6 ID:SGTC_2351|Compound:9026858|FD-Score:4.25|P-value:3.11E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.70|P-value:5.03E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.07|P-value:5.33E-9 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.29|P-value:2.60E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-6.15|P-value:3.74E-9 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.31|P-value:9.29E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.22|P-value:3.62E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.72|P-value:3.45E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:4.20|P-value:3.75E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.32|P-value:8.56E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.51|P-value:4.92E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.30|P-value:9.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-5.27|P-value:3.61E-7 ID:SGTC_2803|Compound:7707263|FD-Score:-4.34|P-value:2.29E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.38|P-value:7.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:5.80|P-value:2.33E-8 ID:SGTC_2928|Compound:9011484|FD-Score:3.67|P-value:2.70E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.04|P-value:7.40E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.92|P-value:1.15E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.97|P-value:9.03E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.37|P-value:7.80E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.64|P-value:6.08E-6 ID:SGTC_3199|Compound:9111318|FD-Score:5.94|P-value:1.07E-8

Top fitness defect scores for YPL204W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_173 1273-0061 12.30 2.7 µM 3.33E-31 mitochondrial stress 2 6.65E-35 0.40
2 SGTC_2122 5258151 9.09 111.7 µM 5.28E-18 1 4.84E-20 3.29
3 SGTC_44 0929-0055 6.44 61.2 µM 6.21E-10 1 5.80E-11 0.90
4 SGTC_2418 pentamidine 6.07 31.7 µM 5.33E-9 mitochondrial processes 7 6.49E-10 0.94
5 SGTC_3199 9111318 5.94 49.5 µM 1.07E-8 3 1.42E-9 0.55
6 SGTC_2815 7968870 5.80 71.4 µM 2.33E-8 2 3.41E-9 0.69
7 SGTC_2124 5246320 5.78 200.0 µM 2.59E-8 heme biosynthesis & mitochondrial translocase 16 3.82E-9 0.08
8 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 5.72 13.2 µM 3.45E-8 3 5.28E-9 0.36
9 SGTC_42 0133-0086 5.66 60.6 µM 4.86E-8 2 7.76E-9 0.94
10 SGTC_2291 7917025 5.00 104.3 µM 1.24E-6 iron homeostasis 5 2.94E-7 0.02
11 SGTC_2008 4012253 4.69 172.0 µM 4.86E-6 5 1.36E-6 0.20
12 SGTC_3029 9088683 4.64 49.5 µM 6.08E-6 2 1.75E-6 0.52
13 SGTC_528 3492-0019 4.63 172.0 µM 6.23E-6 calcium & mitochondrial duress 16 1.80E-6 0.12
14 SGTC_920 mycophenolic acid 4.50 780.4 nM 1.08E-5 1 3.32E-6 0.54
15 SGTC_1016 4226-1401 4.45 38.0 µM 1.35E-5 RNA pol III & RNase P/MRP 12 4.29E-6 0.04
16 SGTC_2496 diffractaic acid 4.29 79.8 µM 2.60E-5 3 8.90E-6 0.08
17 SGTC_2351 9026858 4.25 72.3 µM 3.11E-5 RNA processing & uracil transport 10 1.09E-5 0.20
18 SGTC_504 lovastatin 4.24 124.0 µM 3.19E-5 4 1.12E-5 0.22
19 SGTC_1541 2',3',6-trimethoxyflavone 4.23 64.0 µM 3.32E-5 2 1.17E-5 0.13
20 SGTC_2777 climbazole 4.20 1.5 µM 3.75E-5 iron homeostasis 3 1.34E-5 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.17E-14 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.125 4.52E-13 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.124 6.01E-13 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.123 7.49E-13 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.114 3.26E-11 YER154W OXA1 hom Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals
0.111 9.64E-11 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.111 9.83E-11 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.109 2.28E-10 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.109 2.81E-10 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.107 4.66E-10 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.104 1.69E-9 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.104 1.81E-9 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.103 2.02E-9 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.101 4.04E-9 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.099 7.80E-9 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells