YPL221W / FLC1

Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL221W / FLC1

Click on Significant Values for Screen Details ID:SGTC_574|Compound:1315-0397|FD-Score:4.16|P-value:8.03E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:3.47|P-value:1.61E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.18|P-value:4.90E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.43|P-value:1.88E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.00|P-value:9.39E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.81|P-value:3.01E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:5.61|P-value:3.05E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:3.59|P-value:1.00E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.03|P-value:8.57E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.32|P-value:2.91E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.04|P-value:8.26E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.01|P-value:1.62E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.61|P-value:9.26E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.00|P-value:9.36E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.59|P-value:9.99E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.57|P-value:1.10E-6 ID:SGTC_1720|Compound:st037298|FD-Score:7.13|P-value:7.14E-14 ID:SGTC_1725|Compound:st036284|FD-Score:4.77|P-value:3.84E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-3.46|P-value:1.62E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.90|P-value:2.64E-5 ID:SGTC_1897|Compound:st060201|FD-Score:-3.44|P-value:1.80E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.85|P-value:3.34E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.31|P-value:3.07E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.85|P-value:3.34E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.02|P-value:8.60E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.08|P-value:7.10E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.83|P-value:3.57E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.25|P-value:3.83E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.04|P-value:8.26E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.12|P-value:9.66E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-3.74|P-value:5.14E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.22|P-value:4.22E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.29|P-value:3.24E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.21|P-value:4.46E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.23|P-value:4.06E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.07|P-value:7.26E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.25|P-value:3.72E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.16|P-value:8.03E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:3.47|P-value:1.61E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.18|P-value:4.90E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.43|P-value:1.88E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.00|P-value:9.39E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.81|P-value:3.01E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:5.61|P-value:3.05E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:3.59|P-value:1.00E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.03|P-value:8.57E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.32|P-value:2.91E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.04|P-value:8.26E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.01|P-value:1.62E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.61|P-value:9.26E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.00|P-value:9.36E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.59|P-value:9.99E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.57|P-value:1.10E-6 ID:SGTC_1720|Compound:st037298|FD-Score:7.13|P-value:7.14E-14 ID:SGTC_1725|Compound:st036284|FD-Score:4.77|P-value:3.84E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-3.46|P-value:1.62E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.90|P-value:2.64E-5 ID:SGTC_1897|Compound:st060201|FD-Score:-3.44|P-value:1.80E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.85|P-value:3.34E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.31|P-value:3.07E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.85|P-value:3.34E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.02|P-value:8.60E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.08|P-value:7.10E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.83|P-value:3.57E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.25|P-value:3.83E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.04|P-value:8.26E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.12|P-value:9.66E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-3.74|P-value:5.14E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.22|P-value:4.22E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.29|P-value:3.24E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.21|P-value:4.46E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.23|P-value:4.06E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.07|P-value:7.26E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.25|P-value:3.72E-4

Top fitness defect scores for YPL221W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 7.13 9.5 µM 7.14E-14 6 4.95E-13
2 SGTC_823 0417-1665 5.61 178.0 µM 3.05E-9 19 1.02E-8
3 SGTC_769 0302-0231 4.81 76.0 µM 3.01E-7 19 7.38E-7
4 SGTC_1725 st036284 4.77 20.6 µM 3.84E-7 15 9.25E-7
5 SGTC_1638 st008370 4.57 60.6 µM 1.10E-6 ergosterol biosynthesis 19 2.47E-6
6 SGTC_574 1315-0397 4.16 40.0 µM 8.03E-6 28 1.58E-5
7 SGTC_2703 st077852 4.12 53.4 µM 9.66E-6 18 1.87E-5
8 SGTC_1298 1079-1278 4.01 263.0 µM 1.62E-5 DNA damage response 14 3.04E-5
9 SGTC_2148 5546263 3.85 113.6 µM 3.34E-5 22 5.96E-5
10 SGTC_2001 4023502 3.85 57.7 µM 3.34E-5 mitochondrial processes 20 5.97E-5
11 SGTC_2498 4'-Methoxychalcone 3.83 54.6 µM 3.57E-5 RPP1 & pyrimidine depletion 40 6.35E-5
12 SGTC_1479 0549-0158 3.61 134.0 µM 9.26E-5 41 1.55E-4
13 SGTC_1586 deoxycorticosterone acetate 3.59 53.7 µM 9.99E-5 21 1.66E-4
14 SGTC_921 1561-0023 3.59 372.0 µM 1.00E-4 24 1.66E-4
15 SGTC_624 k048-0052 3.47 28.0 µM 1.61E-4 Golgi 26 2.59E-4
16 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.40 19.1 µM 2.15E-4 45 3.41E-4
17 SGTC_2265 7929201 3.38 200.0 µM 2.28E-4 41 3.59E-4
18 SGTC_1077 5-fluorocytosine 3.32 377.0 nM 2.91E-4 exosome 36 4.51E-4
19 SGTC_2057 5236571 3.31 38.3 µM 3.07E-4 RPP1 & pyrimidine depletion 65 4.75E-4
20 SGTC_2975 9084847 3.29 53.7 µM 3.24E-4 52 4.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.23E-13 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.118 7.38E-12 YGL177W_d YGL177W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.12E-11 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.113 5.35E-11 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.105 1.05E-9 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.104 1.36E-9 YPR075C OPY2 hom Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress
0.102 3.32E-9 YHR079C-A SAE3 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.100 5.86E-9 YNR009W NRM1 hom Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
0.100 6.76E-9 YOL042W NGL1 hom Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092 9.47E-8 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.087 4.13E-7 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.083 1.65E-6 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.082 2.26E-6 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.080 3.39E-6 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.076 1.01E-5 YIL152W_p YIL152W_p hom Putative protein of unknown function