YPL224C / MMT2

Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL224C / MMT2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.72|P-value:6.78E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.11|P-value:1.59E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:6.47|P-value:1.83E-11 ID:SGTC_431|Compound:k089-0097|FD-Score:3.08|P-value:7.73E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.12|P-value:6.80E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.18|P-value:5.38E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.94|P-value:2.65E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.39|P-value:2.54E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.35|P-value:3.63E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.34|P-value:4.44E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:6.69|P-value:4.00E-12 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.87|P-value:1.13E-12 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.91|P-value:3.06E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.66|P-value:8.67E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.52|P-value:1.87E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.13|P-value:6.58E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.20|P-value:6.31E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.49|P-value:2.81E-6 ID:SGTC_1675|Compound:st018485|FD-Score:-5.15|P-value:9.24E-8 ID:SGTC_1683|Compound:st010134|FD-Score:-3.21|P-value:6.06E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.42|P-value:2.23E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.29|P-value:3.69E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.56|P-value:1.60E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.23|P-value:5.61E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.27|P-value:3.92E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.01|P-value:2.01E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.89|P-value:3.30E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.96|P-value:3.16E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.12|P-value:1.22E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.86|P-value:3.77E-5 ID:SGTC_2641|Compound:levomentholum|FD-Score:5.14|P-value:7.20E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.05|P-value:1.68E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.48|P-value:2.23E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.13|P-value:6.43E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.50|P-value:2.06E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.62|P-value:1.26E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.39|P-value:3.43E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.72|P-value:6.78E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.11|P-value:1.59E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:6.47|P-value:1.83E-11 ID:SGTC_431|Compound:k089-0097|FD-Score:3.08|P-value:7.73E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.12|P-value:6.80E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.18|P-value:5.38E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.94|P-value:2.65E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.39|P-value:2.54E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.35|P-value:3.63E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.34|P-value:4.44E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:6.69|P-value:4.00E-12 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.87|P-value:1.13E-12 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.91|P-value:3.06E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.66|P-value:8.67E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.52|P-value:1.87E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.13|P-value:6.58E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.20|P-value:6.31E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.49|P-value:2.81E-6 ID:SGTC_1675|Compound:st018485|FD-Score:-5.15|P-value:9.24E-8 ID:SGTC_1683|Compound:st010134|FD-Score:-3.21|P-value:6.06E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.42|P-value:2.23E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.29|P-value:3.69E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.56|P-value:1.60E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.23|P-value:5.61E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.27|P-value:3.92E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.01|P-value:2.01E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.89|P-value:3.30E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.96|P-value:3.16E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.12|P-value:1.22E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.86|P-value:3.77E-5 ID:SGTC_2641|Compound:levomentholum|FD-Score:5.14|P-value:7.20E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.05|P-value:1.68E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.48|P-value:2.23E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.13|P-value:6.43E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.50|P-value:2.06E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.62|P-value:1.26E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.39|P-value:3.43E-6

Top fitness defect scores for YPL224C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1053 3366-3204 6.87 134.0 µM 1.13E-12 cell wall 3 3.32E-12
2 SGTC_968 1309-0633 6.69 340.0 µM 4.00E-12 1 1.12E-11
3 SGTC_367 0335-0881 6.47 7.1 µM 1.83E-11 ubiquinone biosynthesis & proteasome 21 4.82E-11
4 SGTC_2641 levomentholum 5.14 100.0 µM 7.20E-8 3 1.38E-7
5 SGTC_2787 5284540 4.48 71.4 µM 2.23E-6 14 3.74E-6
6 SGTC_3308 9128332 4.39 17.6 µM 3.43E-6 plasma membrane duress 63 5.65E-6
7 SGTC_967 1306-0166 4.34 352.0 µM 4.44E-6 20 7.25E-6
8 SGTC_2567 aureobasidin a 4.12 60.0 nM 1.22E-5 90 1.92E-5
9 SGTC_2767 sibutramine 4.05 71.5 µM 1.68E-5 19 2.60E-5
10 SGTC_2309 7664088 4.01 163.9 µM 2.01E-5 26 3.10E-5
11 SGTC_608 k048-0125 3.94 159.0 µM 2.65E-5 32 4.03E-5
12 SGTC_1054 3429-0080 3.91 167.0 µM 3.06E-5 28 4.63E-5
13 SGTC_2311 7694451 3.89 200.0 µM 3.30E-5 17 4.99E-5
14 SGTC_2608 thymoquinone 3.86 42.7 µM 3.77E-5 18 5.66E-5
15 SGTC_44 0929-0055 3.72 61.2 µM 6.78E-5 39 9.94E-5
16 SGTC_1086 cerivastatin 3.66 2.2 µM 8.67E-5 azole & statin 19 1.26E-4
17 SGTC_1697 st025554 3.42 27.7 µM 2.23E-4 35 3.12E-4
18 SGTC_2791 5663188 3.40 71.4 µM 2.43E-4 RPP1 & pyrimidine depletion 39 3.38E-4
19 SGTC_956 1185-0240 3.39 191.0 µM 2.54E-4 42 3.54E-4
20 SGTC_1734 st037168 3.29 69.4 µM 3.69E-4 51 5.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.55E-18 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.135 4.28E-15 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.125 3.24E-13 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.114 3.28E-11 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.113 4.72E-11 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.112 7.72E-11 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.109 2.15E-10 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.105 9.18E-10 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.105 1.13E-9 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.101 3.90E-9 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.101 4.75E-9 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.100 7.57E-9 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.096 2.56E-8 YPL052W OAZ1 hom Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p
0.092 9.31E-8 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.092 9.63E-8 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p