YPL230W / USV1

Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL230W / USV1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.33|P-value:1.50E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:2.88|P-value:9.13E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.90|P-value:1.31E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.19|P-value:2.75E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.05|P-value:4.76E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:2.90|P-value:8.29E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.15|P-value:4.67E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.06|P-value:4.66E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.99|P-value:6.10E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.28|P-value:2.91E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.24|P-value:2.45E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.98|P-value:8.77E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-4.01|P-value:1.19E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.13|P-value:3.56E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.08|P-value:6.26E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.16|P-value:3.10E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.05|P-value:6.80E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.48|P-value:8.63E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:2.91|P-value:8.17E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.71|P-value:4.80E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.89|P-value:1.20E-7 ID:SGTC_995|Compound:3931-2021|FD-Score:3.28|P-value:1.91E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.01|P-value:5.60E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.93|P-value:7.56E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.56|P-value:6.08E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.86|P-value:9.70E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.23|P-value:2.36E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.23|P-value:3.48E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.88|P-value:1.33E-10 ID:SGTC_1915|Compound:st067105|FD-Score:-3.32|P-value:2.48E-4 ID:SGTC_1943|Compound:st076331|FD-Score:2.93|P-value:7.60E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.89|P-value:8.63E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.50|P-value:1.19E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.68|P-value:5.52E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.18|P-value:4.28E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.99|P-value:8.49E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.74|P-value:4.13E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.13|P-value:5.15E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.13|P-value:3.55E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.70|P-value:3.17E-5 ID:SGTC_3083|Compound:9117465|FD-Score:4.45|P-value:8.33E-7 ID:SGTC_3173|Compound:9105693|FD-Score:-3.13|P-value:5.20E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.33|P-value:1.50E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:2.88|P-value:9.13E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.90|P-value:1.31E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.19|P-value:2.75E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.05|P-value:4.76E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:2.90|P-value:8.29E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.15|P-value:4.67E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.06|P-value:4.66E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.99|P-value:6.10E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.28|P-value:2.91E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.24|P-value:2.45E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.98|P-value:8.77E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-4.01|P-value:1.19E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.13|P-value:3.56E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.08|P-value:6.26E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.16|P-value:3.10E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.05|P-value:6.80E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.48|P-value:8.63E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:2.91|P-value:8.17E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.71|P-value:4.80E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.89|P-value:1.20E-7 ID:SGTC_995|Compound:3931-2021|FD-Score:3.28|P-value:1.91E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.01|P-value:5.60E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.93|P-value:7.56E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.56|P-value:6.08E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.86|P-value:9.70E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.23|P-value:2.36E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.23|P-value:3.48E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.88|P-value:1.33E-10 ID:SGTC_1915|Compound:st067105|FD-Score:-3.32|P-value:2.48E-4 ID:SGTC_1943|Compound:st076331|FD-Score:2.93|P-value:7.60E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.89|P-value:8.63E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.50|P-value:1.19E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.68|P-value:5.52E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.18|P-value:4.28E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.99|P-value:8.49E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.74|P-value:4.13E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.13|P-value:5.15E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.13|P-value:3.55E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.70|P-value:3.17E-5 ID:SGTC_3083|Compound:9117465|FD-Score:4.45|P-value:8.33E-7 ID:SGTC_3173|Compound:9105693|FD-Score:-3.13|P-value:5.20E-4

Top fitness defect scores for YPL230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1909 st060837 5.88 51.5 µM 1.33E-10 19 2.06E-9
2 SGTC_3083 9117465 4.45 49.5 µM 8.33E-7 8 4.36E-6
3 SGTC_21 0849-0113 4.33 23.0 µM 1.50E-6 23 7.32E-6
4 SGTC_656 4090-1979 4.24 187.0 µM 2.45E-6 10 1.12E-5
5 SGTC_67 0335-0847 3.90 266.0 µM 1.31E-5 ubiquinone biosynthesis & proteasome 121 4.87E-5
6 SGTC_2926 9010726 3.70 65.2 µM 3.17E-5 39 1.06E-4
7 SGTC_1296 1068-0102 3.56 11.9 µM 6.08E-5 15 1.87E-4
8 SGTC_881 0833-0569 3.48 170.0 µM 8.63E-5 51 2.54E-4
9 SGTC_2069 5228469 3.41 200.0 µM 1.14E-4 29 3.25E-4
10 SGTC_2100 5377183 3.36 190.0 µM 1.38E-4 60S ribosome export 27 3.85E-4
11 SGTC_995 3931-2021 3.28 34.6 µM 1.91E-4 RPP1 & pyrimidine depletion 40 5.11E-4
12 SGTC_1469 k284-2957 3.23 126.0 µM 2.36E-4 27 6.14E-4
13 SGTC_164 4100-3994 3.19 89.6 µM 2.75E-4 75 7.03E-4
14 SGTC_875 0709-0210 3.16 25.7 µM 3.10E-4 fatty acid desaturase (OLE1) 61 7.79E-4
15 SGTC_2882 9058044 3.13 58.4 µM 3.55E-4 48 8.79E-4
16 SGTC_805 3852-0218 3.13 479.0 µM 3.56E-4 ERAD & cell cycle 111 8.80E-4
17 SGTC_501 nsc-95397 3.06 161.0 µM 4.66E-4 39 0.00111
18 SGTC_330 1488-0319 3.05 80.1 µM 4.76E-4 RPP1 & pyrimidine depletion 44 0.00114
19 SGTC_1006 4099-6547 3.01 255.0 µM 5.60E-4 75 0.00131
20 SGTC_546 peri-Naphthalide 2.99 147.0 µM 6.10E-4 DNA damage response 50 0.00141

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.69E-14 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.120 3.05E-12 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.116 1.64E-11 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.103 2.45E-9 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.096 2.89E-8 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.093 6.61E-8 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.090 1.56E-7 YDR384C ATO3 hom Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
0.090 1.59E-7 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.089 2.08E-7 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.085 7.18E-7 YML125C PGA3 het Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication
0.085 7.83E-7 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.84E-6 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.076 1.17E-5 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.075 1.31E-5 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.075 1.52E-5 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis