YPL231W / FAS2

Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL231W / FAS2

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.19|P-value:3.37E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.44|P-value:1.16E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.16|P-value:3.86E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.87|P-value:2.93E-17 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.41|P-value:1.42E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.92|P-value:9.48E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.01|P-value:6.69E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:2.93|P-value:8.98E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.92|P-value:9.48E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.02|P-value:6.57E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.90|P-value:9.98E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.05|P-value:5.82E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.87|P-value:1.86E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.05|P-value:8.18E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:2.90|P-value:9.91E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.97|P-value:7.68E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.70|P-value:4.11E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.32|P-value:2.02E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.83|P-value:2.30E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.05|P-value:3.85E-8 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.47|P-value:9.81E-7 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.42|P-value:1.37E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.37|P-value:1.70E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.26|P-value:2.62E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-2.99|P-value:7.54E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.48|P-value:1.04E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.53|P-value:8.54E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.72|P-value:2.52E-7 ID:SGTC_2316|Compound:5844804|FD-Score:6.60|P-value:1.05E-12 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.64|P-value:5.37E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.08|P-value:5.26E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.20|P-value:3.93E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.98|P-value:5.80E-8 ID:SGTC_2623|Compound:humulene|FD-Score:3.68|P-value:4.49E-5 ID:SGTC_2857|Compound:9024691|FD-Score:2.92|P-value:9.52E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.48|P-value:1.05E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.91|P-value:9.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.19|P-value:3.38E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.97|P-value:1.21E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.47|P-value:1.13E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.13|P-value:5.40E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.14|P-value:4.11E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.19|P-value:3.37E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.44|P-value:1.16E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.16|P-value:3.86E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.87|P-value:2.93E-17 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.41|P-value:1.42E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.92|P-value:9.48E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.01|P-value:6.69E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:2.93|P-value:8.98E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.92|P-value:9.48E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.02|P-value:6.57E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.90|P-value:9.98E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.05|P-value:5.82E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.87|P-value:1.86E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.05|P-value:8.18E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:2.90|P-value:9.91E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.97|P-value:7.68E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.70|P-value:4.11E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.32|P-value:2.02E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.83|P-value:2.30E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.05|P-value:3.85E-8 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.47|P-value:9.81E-7 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.42|P-value:1.37E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.37|P-value:1.70E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.26|P-value:2.62E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-2.99|P-value:7.54E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.48|P-value:1.04E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.53|P-value:8.54E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.72|P-value:2.52E-7 ID:SGTC_2316|Compound:5844804|FD-Score:6.60|P-value:1.05E-12 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.64|P-value:5.37E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.08|P-value:5.26E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.20|P-value:3.93E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.98|P-value:5.80E-8 ID:SGTC_2623|Compound:humulene|FD-Score:3.68|P-value:4.49E-5 ID:SGTC_2857|Compound:9024691|FD-Score:2.92|P-value:9.52E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.48|P-value:1.05E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.91|P-value:9.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.19|P-value:3.38E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.97|P-value:1.21E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.47|P-value:1.13E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.13|P-value:5.40E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.14|P-value:4.11E-4

Top fitness defect scores for YPL231W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2316 5844804 6.60 197.4 µM 1.05E-12 2 2.02E-11 1.15
2 SGTC_2136 5328288 4.72 199.3 µM 2.52E-7 7 1.18E-6 0.61
3 SGTC_1362 1611-0397 4.47 101.0 µM 9.81E-7 1 3.93E-6 0.57
4 SGTC_63 0099-0242 4.44 26.7 µM 1.16E-6 mitochondrial stress 17 4.56E-6 0.03
5 SGTC_3289 9119912 4.13 71.4 µM 5.40E-6 4 1.79E-5 0.38
6 SGTC_908 3448-7491 4.05 47.7 µM 8.18E-6 mitochondrial stress 9 2.58E-5 0.31
7 SGTC_783 0848-0141 3.87 92.7 µM 1.86E-5 RSC & ERG11 16 5.35E-5 0.12
8 SGTC_1352 1496-0991 3.83 99.0 µM 2.30E-5 tubulin folding & SWR complex 1 6.46E-5 0.34
9 SGTC_1226 3909-7979 3.70 35.4 µM 4.11E-5 7 1.08E-4 0.21
10 SGTC_2623 humulene 3.68 100.0 µM 4.49E-5 2 1.17E-4 0.05
11 SGTC_2541 muurolladie-3-one 3.64 83.1 µM 5.37E-5 excess fatty acid 22 1.37E-4 0.02
12 SGTC_2126 5251174 3.53 33.9 µM 8.54E-5 15 2.08E-4 0.07
13 SGTC_2046 4110841 3.48 106.0 µM 1.04E-4 iron homeostasis 14 2.47E-4 0.15
14 SGTC_2907 7721985 3.48 69.9 µM 1.05E-4 9 2.50E-4 0.08
15 SGTC_363 0455-0021 3.39 3.1 µM 1.53E-4 azole & statin 25 3.49E-4 0.05
16 SGTC_1228 0124-0032 3.32 52.5 µM 2.02E-4 6 4.46E-4 0.01
17 SGTC_680 0417-1641 3.28 114.0 µM 2.43E-4 RPP1 & pyrimidine depletion 13 5.25E-4 0.12
18 SGTC_562 3772-2733 3.25 112.0 µM 2.72E-4 ERG2 21 5.82E-4 0.02
19 SGTC_55 0767-0285 3.19 6.6 µM 3.37E-4 16 7.03E-4 0.01
20 SGTC_2939 9044578 3.19 71.4 µM 3.38E-4 10 7.06E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 9.26E-23 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.157 7.02E-20 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.136 3.00E-15 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.134 8.19E-15 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.132 1.44E-14 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.124 4.92E-13 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.121 1.77E-12 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.116 1.42E-11 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.116 1.47E-11 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.110 1.50E-10 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.108 2.93E-10 YOL026C MIM1 het Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
0.103 1.85E-9 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.103 2.13E-9 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.103 2.43E-9 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.102 2.91E-9 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis