YPL239W / YAR1

Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL239W / YAR1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:6.09|P-value:2.44E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:3.54|P-value:3.15E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.46|P-value:4.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.14|P-value:4.91E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.19|P-value:9.91E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.69|P-value:1.82E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.70|P-value:2.07E-8 ID:SGTC_704|Compound:1310-0270|FD-Score:5.17|P-value:3.30E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:3.38|P-value:5.37E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.59|P-value:1.62E-13 ID:SGTC_830|Compound:4076-0286|FD-Score:5.53|P-value:5.16E-8 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.99|P-value:1.24E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:3.71|P-value:1.66E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.38|P-value:5.45E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.57|P-value:5.34E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.54|P-value:5.03E-8 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.71|P-value:2.47E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.40|P-value:7.12E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.06|P-value:4.50E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.33|P-value:6.31E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.49|P-value:5.19E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.32|P-value:1.50E-7 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.54|P-value:3.15E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.61|P-value:2.42E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.21|P-value:9.32E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.17|P-value:2.91E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.61|P-value:3.48E-8 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.47|P-value:4.01E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.93|P-value:1.10E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.99|P-value:7.73E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.48|P-value:3.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.22|P-value:9.15E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.15|P-value:3.15E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.94|P-value:1.04E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.80|P-value:1.74E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.74|P-value:3.99E-6 ID:SGTC_2315|Compound:7733312|FD-Score:4.09|P-value:3.92E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.45|P-value:4.20E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.79|P-value:1.84E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.45|P-value:5.94E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.22|P-value:2.33E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.73|P-value:1.56E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.42|P-value:4.64E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.52|P-value:5.42E-8 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.34|P-value:1.45E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:5.10|P-value:4.54E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.36|P-value:5.77E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.37|P-value:7.75E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.21|P-value:9.39E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.86|P-value:9.84E-5 ID:SGTC_2862|Compound:9027634|FD-Score:4.03|P-value:5.05E-5 ID:SGTC_2914|Compound:7968218|FD-Score:3.87|P-value:9.43E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.76|P-value:2.05E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.78|P-value:1.29E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.82|P-value:1.70E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.85|P-value:1.01E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.69|P-value:1.84E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:6.09|P-value:2.44E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:3.54|P-value:3.15E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.46|P-value:4.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.14|P-value:4.91E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.19|P-value:9.91E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.69|P-value:1.82E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.70|P-value:2.07E-8 ID:SGTC_704|Compound:1310-0270|FD-Score:5.17|P-value:3.30E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:3.38|P-value:5.37E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.59|P-value:1.62E-13 ID:SGTC_830|Compound:4076-0286|FD-Score:5.53|P-value:5.16E-8 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.99|P-value:1.24E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:3.71|P-value:1.66E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.38|P-value:5.45E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.57|P-value:5.34E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.54|P-value:5.03E-8 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.71|P-value:2.47E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.40|P-value:7.12E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.06|P-value:4.50E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.33|P-value:6.31E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.49|P-value:5.19E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.32|P-value:1.50E-7 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.54|P-value:3.15E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.61|P-value:2.42E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.21|P-value:9.32E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.17|P-value:2.91E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.61|P-value:3.48E-8 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.47|P-value:4.01E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.93|P-value:1.10E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.99|P-value:7.73E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.48|P-value:3.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.22|P-value:9.15E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.15|P-value:3.15E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.94|P-value:1.04E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.80|P-value:1.74E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.74|P-value:3.99E-6 ID:SGTC_2315|Compound:7733312|FD-Score:4.09|P-value:3.92E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.45|P-value:4.20E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.79|P-value:1.84E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.45|P-value:5.94E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.22|P-value:2.33E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.73|P-value:1.56E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.42|P-value:4.64E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.52|P-value:5.42E-8 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.34|P-value:1.45E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:5.10|P-value:4.54E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.36|P-value:5.77E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.37|P-value:7.75E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.21|P-value:9.39E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.86|P-value:9.84E-5 ID:SGTC_2862|Compound:9027634|FD-Score:4.03|P-value:5.05E-5 ID:SGTC_2914|Compound:7968218|FD-Score:3.87|P-value:9.43E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.76|P-value:2.05E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.78|P-value:1.29E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.82|P-value:1.70E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.85|P-value:1.01E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.69|P-value:1.84E-4

Top fitness defect scores for YPL239W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 7.59 155.0 µM 1.62E-13 translation 18 1.58E-14
2 SGTC_33 0986-0033 6.09 35.8 µM 2.44E-9 calcium & mitochondrial duress 7 5.70E-10
3 SGTC_582 0987-0078 5.70 156.0 µM 2.07E-8 calcium & mitochondrial duress 25 5.88E-9
4 SGTC_1781 st038725 5.61 66.3 µM 3.48E-8 NEO1 62 1.03E-8
5 SGTC_1207 2099-0101 5.54 141.0 µM 5.03E-8 3 1.54E-8
6 SGTC_830 4076-0286 5.53 57.8 µM 5.16E-8 translation 22 1.59E-8
7 SGTC_2605 digitonin 5.52 300.0 nM 5.42E-8 6 1.67E-8
8 SGTC_1479 0549-0158 5.32 134.0 µM 1.50E-7 7 5.06E-8
9 SGTC_704 1310-0270 5.17 142.0 µM 3.30E-7 12 1.19E-7
10 SGTC_2614 arthonioic acid 5.10 13.4 µM 4.54E-7 6 1.69E-7
11 SGTC_1958 st076513 4.99 41.9 µM 7.73E-7 60S ribosome export 14 3.01E-7
12 SGTC_2938 9059746 4.82 27.3 µM 1.70E-6 fatty acid desaturase (OLE1) 23 7.06E-7
13 SGTC_1053 3366-3204 4.57 134.0 µM 5.34E-6 cell wall 20 2.45E-6
14 SGTC_2608 thymoquinone 4.34 42.7 µM 1.45E-5 10 7.23E-6
15 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.22 54.6 µM 2.33E-5 RPP1 & pyrimidine depletion 25 1.21E-5
16 SGTC_1746 st038117 4.17 42.0 µM 2.91E-5 26 1.54E-5
17 SGTC_2269 7935389 4.15 174.4 µM 3.15E-5 tubulin folding & SWR complex 21 1.68E-5
18 SGTC_2315 7733312 4.09 200.0 µM 3.92E-5 21 2.13E-5
19 SGTC_1253 0550-0034 4.06 176.0 µM 4.50E-5 19 2.48E-5
20 SGTC_2862 9027634 4.03 71.4 µM 5.05E-5 ERG2 29 2.80E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.07E-42 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.213 8.48E-36 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.164 9.73E-22 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.163 2.42E-21 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.162 4.82E-21 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.153 5.63E-19 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.146 2.13E-17 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.141 2.87E-16 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.137 1.83E-15 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.134 5.92E-15 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.134 7.17E-15 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.131 2.21E-14 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.124 4.77E-13 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.124 6.77E-13 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.123 8.04E-13 YBR017C KAP104 hom Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis