YPL246C / RBD2

Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL246C / RBD2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-7.65|P-value:3.01E-16 ID:SGTC_67|Compound:0335-0847|FD-Score:3.92|P-value:1.59E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.34|P-value:1.98E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.55|P-value:8.76E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.95|P-value:1.36E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:2.96|P-value:8.31E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.47|P-value:1.14E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.59|P-value:7.05E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.25|P-value:2.75E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.04|P-value:6.24E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-13.40|P-value:9.90E-46 ID:SGTC_820|Compound:1582-0060|FD-Score:3.27|P-value:2.59E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.48|P-value:1.20E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.08|P-value:5.81E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.34|P-value:2.10E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.64|P-value:5.56E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.67|P-value:4.86E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.68|P-value:4.73E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.01|P-value:6.93E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.71|P-value:4.03E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-4.50|P-value:9.78E-7 ID:SGTC_2069|Compound:5228469|FD-Score:2.99|P-value:7.37E-4 ID:SGTC_2102|Compound:5377816|FD-Score:5.96|P-value:1.26E-10 ID:SGTC_2267|Compound:7931562|FD-Score:-2.96|P-value:8.88E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.05|P-value:9.63E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.73|P-value:3.81E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-4.74|P-value:2.70E-7 ID:SGTC_2344|Compound:7990960|FD-Score:-3.88|P-value:2.06E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.66|P-value:1.14E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.50|P-value:9.95E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.65|P-value:5.38E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.10|P-value:5.38E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.58|P-value:1.63E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.02|P-value:6.62E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.54|P-value:9.25E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.05|P-value:8.46E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.01|P-value:7.38E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.08|P-value:5.25E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.61|P-value:6.43E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.47|P-value:1.15E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.01|P-value:6.88E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.63|P-value:5.70E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.91|P-value:1.67E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.02|P-value:7.20E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.84|P-value:1.41E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.65|P-value:3.01E-16 ID:SGTC_67|Compound:0335-0847|FD-Score:3.92|P-value:1.59E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.34|P-value:1.98E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.55|P-value:8.76E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.95|P-value:1.36E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:2.96|P-value:8.31E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.47|P-value:1.14E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.59|P-value:7.05E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.25|P-value:2.75E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.04|P-value:6.24E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-13.40|P-value:9.90E-46 ID:SGTC_820|Compound:1582-0060|FD-Score:3.27|P-value:2.59E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.48|P-value:1.20E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.08|P-value:5.81E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.34|P-value:2.10E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.64|P-value:5.56E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.67|P-value:4.86E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.68|P-value:4.73E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.01|P-value:6.93E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.71|P-value:4.03E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-4.50|P-value:9.78E-7 ID:SGTC_2069|Compound:5228469|FD-Score:2.99|P-value:7.37E-4 ID:SGTC_2102|Compound:5377816|FD-Score:5.96|P-value:1.26E-10 ID:SGTC_2267|Compound:7931562|FD-Score:-2.96|P-value:8.88E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.05|P-value:9.63E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.73|P-value:3.81E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-4.74|P-value:2.70E-7 ID:SGTC_2344|Compound:7990960|FD-Score:-3.88|P-value:2.06E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.66|P-value:1.14E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.50|P-value:9.95E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.65|P-value:5.38E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.10|P-value:5.38E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.58|P-value:1.63E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.02|P-value:6.62E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.54|P-value:9.25E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.05|P-value:8.46E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.01|P-value:7.38E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.08|P-value:5.25E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.61|P-value:6.43E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.47|P-value:1.15E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.01|P-value:6.88E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.63|P-value:5.70E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.91|P-value:1.67E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.02|P-value:7.20E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.84|P-value:1.41E-7

Top fitness defect scores for YPL246C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2102 5377816 5.96 72.8 µM 1.26E-10 2 1.23E-9
2 SGTC_2571 chrysanthemic acid 5.58 100.0 µM 1.63E-9 4 1.21E-8
3 SGTC_3209 9113616 4.84 49.5 µM 1.41E-7 9 6.48E-7
4 SGTC_2765 myclobutanil 4.05 7.7 µM 8.46E-6 azole & statin 45 2.52E-5
5 SGTC_158 k038-0087 3.95 26.4 µM 1.36E-5 ubiquinone biosynthesis & proteasome 140 3.85E-5
6 SGTC_67 0335-0847 3.92 266.0 µM 1.59E-5 ubiquinone biosynthesis & proteasome 119 4.43E-5
7 SGTC_3087 9117406 3.91 49.5 µM 1.67E-5 18 4.64E-5
8 SGTC_2311 7694451 3.73 200.0 µM 3.81E-5 25 9.70E-5
9 SGTC_1637 st007924 3.71 17.4 µM 4.03E-5 31 1.02E-4
10 SGTC_1178 0988-0033 3.68 191.0 µM 4.73E-5 36 1.18E-4
11 SGTC_1151 3909-8316 3.67 15.3 µM 4.86E-5 25 1.21E-4
12 SGTC_2411 st077133 3.65 39.9 µM 5.38E-5 RNA pol III & RNase P/MRP 39 1.32E-4
13 SGTC_1140 3229-1848 3.64 3.0 µM 5.56E-5 15 1.36E-4
14 SGTC_2949 9072542 3.63 2.2 µM 5.70E-5 TSC3-RPN4 49 1.39E-4
15 SGTC_2825 7998094 3.61 58.4 µM 6.43E-5 fatty acid desaturase (OLE1) 42 1.55E-4
16 SGTC_413 propylparaben 3.59 100.0 µM 7.05E-5 amide catabolism 32 1.68E-4
17 SGTC_168 3970-0862 3.47 530.5 µM 1.14E-4 160 2.58E-4
18 SGTC_2927 9011802 3.47 47.9 µM 1.15E-4 41 2.62E-4
19 SGTC_73 0327-0325 3.34 16.2 µM 1.98E-4 DNA damage response 75 4.26E-4
20 SGTC_820 1582-0060 3.27 59.9 µM 2.59E-4 63 5.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.364 1.67E-105 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.341 8.11E-92 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.326 6.82E-84 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.322 6.31E-82 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.289 1.99E-65 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.285 6.23E-64 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.272 4.57E-58 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.269 8.88E-57 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.264 1.77E-54 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.250 4.34E-49 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.247 8.57E-48 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.223 7.35E-39 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.215 1.48E-36 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.212 3.34E-35 YDR242W AMD2 hom Putative amidase
0.210 7.06E-35 YOR014W RTS1 hom B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A