YPL253C / VIK1

Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL253C / VIK1

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:-3.15|P-value:9.27E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.22|P-value:1.56E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.24|P-value:6.96E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.55|P-value:2.30E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.80|P-value:8.66E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.91|P-value:5.65E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.53|P-value:2.40E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.16|P-value:9.19E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.90|P-value:6.00E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.50|P-value:2.73E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.16|P-value:9.09E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.40|P-value:7.00E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.44|P-value:3.47E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.37|P-value:4.34E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.29|P-value:5.85E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.15|P-value:9.44E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.15|P-value:9.20E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.47|P-value:3.09E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.14|P-value:9.77E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.20|P-value:8.04E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.41|P-value:6.56E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.37|P-value:4.38E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.06|P-value:3.06E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:6.29|P-value:2.59E-10 ID:SGTC_1636|Compound:st007707|FD-Score:3.34|P-value:4.90E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.91|P-value:6.38E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.24|P-value:1.13E-7 ID:SGTC_1887|Compound:st057648|FD-Score:-3.74|P-value:1.07E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.87|P-value:6.56E-5 ID:SGTC_1911|Compound:st060208|FD-Score:3.70|P-value:1.28E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.31|P-value:5.36E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.14|P-value:9.62E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.44|P-value:3.45E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.25|P-value:6.71E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.24|P-value:1.38E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.61|P-value:1.85E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.06|P-value:3.04E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.31|P-value:5.48E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.56|P-value:2.23E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.14|P-value:9.79E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.69|P-value:1.35E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.15|P-value:9.27E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.22|P-value:1.56E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.24|P-value:6.96E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.55|P-value:2.30E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.80|P-value:8.66E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.91|P-value:5.65E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.53|P-value:2.40E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.16|P-value:9.19E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.90|P-value:6.00E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.50|P-value:2.73E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.16|P-value:9.09E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.40|P-value:7.00E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.44|P-value:3.47E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.37|P-value:4.34E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.29|P-value:5.85E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.15|P-value:9.44E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.15|P-value:9.20E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.47|P-value:3.09E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.14|P-value:9.77E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.20|P-value:8.04E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.41|P-value:6.56E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.37|P-value:4.38E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.06|P-value:3.06E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:6.29|P-value:2.59E-10 ID:SGTC_1636|Compound:st007707|FD-Score:3.34|P-value:4.90E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.91|P-value:6.38E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.24|P-value:1.13E-7 ID:SGTC_1887|Compound:st057648|FD-Score:-3.74|P-value:1.07E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.87|P-value:6.56E-5 ID:SGTC_1911|Compound:st060208|FD-Score:3.70|P-value:1.28E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.31|P-value:5.36E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.14|P-value:9.62E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.44|P-value:3.45E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.25|P-value:6.71E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.24|P-value:1.38E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.61|P-value:1.85E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.06|P-value:3.04E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.31|P-value:5.48E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.56|P-value:2.23E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.14|P-value:9.79E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.69|P-value:1.35E-4

Top fitness defect scores for YPL253C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1570 verbenone 6.29 133.0 µM 2.59E-10 3 1.56E-10
2 SGTC_1877 wortmannin 5.24 25.0 µM 1.13E-7 61 7.93E-8
3 SGTC_1722 st034304 4.91 3.6 µM 6.38E-7 mitochondrial processes 12 4.66E-7
4 SGTC_1237 0330-0133 4.41 46.1 µM 6.56E-6 ergosterol biosynthesis 17 5.08E-6
5 SGTC_754 3474-0146 4.40 171.0 µM 7.00E-6 copper-dependent oxidative stress 14 5.42E-6
6 SGTC_114 0364-0001 4.22 490.3 µM 1.56E-5 44 1.23E-5
7 SGTC_1523 st012844 4.06 44.7 µM 3.06E-5 60S ribosome export 16 2.46E-5
8 SGTC_275 trichlorophene 3.91 5.7 µM 5.65E-5 mitochondrial stress 231 4.61E-5
9 SGTC_528 3492-0019 3.90 172.0 µM 6.00E-5 calcium & mitochondrial duress 225 4.90E-5
10 SGTC_241 5hr heat shock (37°C) + cantharidin 3.80 155.4 µM 8.66E-5 cell wall signaling 79 7.13E-5
11 SGTC_1911 st060208 3.70 74.3 µM 1.28E-4 43 1.06E-4
12 SGTC_3324 9138759 3.69 60.8 µM 1.35E-4 25 1.12E-4
13 SGTC_2640 pentamidine 3.61 10.4 µM 1.85E-4 mitochondrial processes 43 1.55E-4
14 SGTC_2413 inermin 3.59 26.1 µM 1.95E-4 68 1.64E-4
15 SGTC_3069 9117009 3.56 49.5 µM 2.23E-4 60S ribosome export 13 1.88E-4
16 SGTC_226 1,3-diallylurea 3.55 8.3 mM 2.30E-4 16 1.93E-4
17 SGTC_997 3996-0078 3.53 137.0 µM 2.43E-4 39 2.05E-4
18 SGTC_951 1171-0579 3.47 82.7 µM 3.09E-4 cell wall 109 2.62E-4
19 SGTC_2476 5806916 3.44 10.5 µM 3.45E-4 28 2.94E-4
20 SGTC_761 k216-0224 3.44 480.0 µM 3.47E-4 41 2.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 1.99E-11 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.115 2.14E-11 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.104 1.47E-9 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.76E-9 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.103 2.10E-9 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.101 5.32E-9 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.097 1.87E-8 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.097 1.93E-8 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.094 4.60E-8 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.091 1.33E-7 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.087 3.96E-7 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.086 5.38E-7 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.083 1.41E-6 YPL008W CHL1 hom Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome
0.082 1.71E-6 YDR195W REF2 hom RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
0.082 1.81E-6 YOL076W MDM20 hom Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly