YPL261C_d

Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL261C / YPL261C

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.08|P-value:1.37E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.06|P-value:7.59E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.11|P-value:6.41E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.70|P-value:7.25E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.95|P-value:2.46E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.28|P-value:3.70E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.25|P-value:4.19E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.70|P-value:7.00E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.95|P-value:2.40E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.68|P-value:7.62E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.38|P-value:2.59E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.29|P-value:3.65E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.45|P-value:1.76E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.04|P-value:8.93E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.02|P-value:9.73E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.80|P-value:4.73E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.13|P-value:6.50E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.54|P-value:1.34E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.75|P-value:5.06E-7 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.51|P-value:1.53E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.52|P-value:1.34E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.32|P-value:3.20E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.81|P-value:4.47E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.47|P-value:2.08E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.75|P-value:5.74E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.92|P-value:2.09E-7 ID:SGTC_1934|Compound:st074720|FD-Score:3.87|P-value:3.40E-5 ID:SGTC_1983|Compound:st071813|FD-Score:4.72|P-value:6.09E-7 ID:SGTC_1990|Compound:st072050|FD-Score:4.75|P-value:5.01E-7 ID:SGTC_2068|Compound:5226020|FD-Score:4.59|P-value:1.18E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.48|P-value:1.76E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.32|P-value:4.50E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.25|P-value:3.75E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.27|P-value:5.50E-6 ID:SGTC_2403|Compound:6032726|FD-Score:5.29|P-value:2.56E-8 ID:SGTC_2451|Compound:5856223|FD-Score:3.15|P-value:6.08E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.45|P-value:1.94E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.09|P-value:8.12E-8 ID:SGTC_2803|Compound:7707263|FD-Score:3.37|P-value:2.65E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.21|P-value:4.91E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.28|P-value:5.23E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.03|P-value:9.39E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-4.57|P-value:1.12E-6 ID:SGTC_3303|Compound:9125618|FD-Score:3.07|P-value:7.95E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.26|P-value:5.87E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.08|P-value:1.37E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.06|P-value:7.59E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.11|P-value:6.41E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.70|P-value:7.25E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.95|P-value:2.46E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.28|P-value:3.70E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.25|P-value:4.19E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.70|P-value:7.00E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.95|P-value:2.40E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.68|P-value:7.62E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.38|P-value:2.59E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.29|P-value:3.65E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.45|P-value:1.76E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.04|P-value:8.93E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.02|P-value:9.73E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.80|P-value:4.73E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.13|P-value:6.50E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.54|P-value:1.34E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.75|P-value:5.06E-7 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.51|P-value:1.53E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.52|P-value:1.34E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.32|P-value:3.20E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.81|P-value:4.47E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.47|P-value:2.08E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.75|P-value:5.74E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.92|P-value:2.09E-7 ID:SGTC_1934|Compound:st074720|FD-Score:3.87|P-value:3.40E-5 ID:SGTC_1983|Compound:st071813|FD-Score:4.72|P-value:6.09E-7 ID:SGTC_1990|Compound:st072050|FD-Score:4.75|P-value:5.01E-7 ID:SGTC_2068|Compound:5226020|FD-Score:4.59|P-value:1.18E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.48|P-value:1.76E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.32|P-value:4.50E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.25|P-value:3.75E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.27|P-value:5.50E-6 ID:SGTC_2403|Compound:6032726|FD-Score:5.29|P-value:2.56E-8 ID:SGTC_2451|Compound:5856223|FD-Score:3.15|P-value:6.08E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.45|P-value:1.94E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.09|P-value:8.12E-8 ID:SGTC_2803|Compound:7707263|FD-Score:3.37|P-value:2.65E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.21|P-value:4.91E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.28|P-value:5.23E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.03|P-value:9.39E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-4.57|P-value:1.12E-6 ID:SGTC_3303|Compound:9125618|FD-Score:3.07|P-value:7.95E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.26|P-value:5.87E-6

Top fitness defect scores for YPL261C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 5.29 181.2 µM 2.56E-8 14 6.07E-8
2 SGTC_2628 lathosterol 5.09 100.0 µM 8.12E-8 12 1.80E-7
3 SGTC_1797 st048695 4.92 56.8 µM 2.09E-7 NEO1 54 4.39E-7
4 SGTC_1990 st072050 4.75 59.8 µM 5.01E-7 6 1.00E-6
5 SGTC_1521 st012942 4.75 49.4 µM 5.06E-7 17 1.01E-6
6 SGTC_1983 st071813 4.72 46.9 µM 6.09E-7 RPP1 & pyrimidine depletion 8 1.20E-6
7 SGTC_2068 5226020 4.59 147.0 µM 1.18E-6 17 2.25E-6
8 SGTC_1712 st032288 4.47 53.4 µM 2.08E-6 calcium & mitochondrial duress 148 3.83E-6
9 SGTC_2129 girgensonine 4.32 121.0 µM 4.50E-6 heme biosynthesis & mitochondrial translocase 19 7.96E-6
10 SGTC_2960 9079389 4.28 6.0 µM 5.23E-6 19 9.16E-6
11 SGTC_2402 5553605 4.27 200.0 µM 5.50E-6 14 9.61E-6
12 SGTC_3347 9188721 4.26 44.7 µM 5.87E-6 18 1.02E-5
13 SGTC_1392 3455-1037 4.11 33.9 µM 1.16E-5 8 1.94E-5
14 SGTC_1748 st037455 4.11 53.6 µM 1.16E-5 26 1.95E-5
15 SGTC_45 0kpi-0036 4.08 14.9 µM 1.37E-5 excess fatty acid 20 2.27E-5
16 SGTC_773 4358-1457 3.95 44.6 µM 2.40E-5 44 3.87E-5
17 SGTC_319 1348-1596 3.95 45.5 µM 2.46E-5 RSC & ERG11 18 3.96E-5
18 SGTC_3238 9133470 3.91 49.5 µM 2.90E-5 12 4.62E-5
19 SGTC_1934 st074720 3.87 32.6 µM 3.40E-5 61 5.38E-5
20 SGTC_1636 st007707 3.81 68.9 µM 4.47E-5 52 6.96E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 9.21E-12 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.110 1.76E-10 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.105 1.14E-9 YER128W VFA1 hom Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
0.097 1.81E-8 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.086 6.34E-7 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.086 6.74E-7 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.082 1.85E-6 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.082 1.98E-6 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.081 2.47E-6 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.080 3.36E-6 YOL121C RPS19A hom Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
0.080 3.64E-6 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.078 5.60E-6 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.078 6.13E-6 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.078 7.23E-6 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.074 1.84E-5 YMR194C-A_d YMR194C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data