YPL264C_p

Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL264C / YPL264C

Click on Significant Values for Screen Details ID:SGTC_184|Compound:1494-0393|FD-Score:-3.05|P-value:6.41E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.98|P-value:8.16E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.10|P-value:5.22E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.56|P-value:6.56E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.35|P-value:1.97E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.12|P-value:4.68E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.49|P-value:1.04E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.86|P-value:2.12E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.07|P-value:5.56E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.09|P-value:6.02E-11 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.07|P-value:5.49E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.51|P-value:9.66E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.77|P-value:3.16E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.01|P-value:1.06E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.16|P-value:5.53E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.74|P-value:3.63E-5 ID:SGTC_1839|Compound:st053978|FD-Score:-3.01|P-value:7.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.44|P-value:1.41E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.15|P-value:4.14E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-4.37|P-value:1.91E-6 ID:SGTC_2327|Compound:6189656|FD-Score:-4.26|P-value:3.29E-6 ID:SGTC_2448|Compound:5185112|FD-Score:2.97|P-value:8.14E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.01|P-value:6.89E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.58|P-value:7.76E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-2.97|P-value:8.51E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.77|P-value:3.10E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.44|P-value:1.39E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.09|P-value:5.24E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.92|P-value:8.88E-8 ID:SGTC_2850|Compound:9015429|FD-Score:3.14|P-value:4.20E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.09|P-value:5.39E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.90|P-value:1.72E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.08|P-value:5.44E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.28|P-value:2.52E-4 ID:SGTC_3135|Compound:9127742|FD-Score:2.97|P-value:7.99E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-2.96|P-value:8.65E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.61|P-value:6.28E-5 ID:SGTC_3193|Compound:9111931|FD-Score:6.18|P-value:2.77E-11 ID:SGTC_3202|Compound:9113761|FD-Score:-3.00|P-value:7.53E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.05|P-value:6.41E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.98|P-value:8.16E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.10|P-value:5.22E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.56|P-value:6.56E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.35|P-value:1.97E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.12|P-value:4.68E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.49|P-value:1.04E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.86|P-value:2.12E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.07|P-value:5.56E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.09|P-value:6.02E-11 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.07|P-value:5.49E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.51|P-value:9.66E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.77|P-value:3.16E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.01|P-value:1.06E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.16|P-value:5.53E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.74|P-value:3.63E-5 ID:SGTC_1839|Compound:st053978|FD-Score:-3.01|P-value:7.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.44|P-value:1.41E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.15|P-value:4.14E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-4.37|P-value:1.91E-6 ID:SGTC_2327|Compound:6189656|FD-Score:-4.26|P-value:3.29E-6 ID:SGTC_2448|Compound:5185112|FD-Score:2.97|P-value:8.14E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.01|P-value:6.89E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.58|P-value:7.76E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-2.97|P-value:8.51E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.77|P-value:3.10E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.44|P-value:1.39E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.09|P-value:5.24E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.92|P-value:8.88E-8 ID:SGTC_2850|Compound:9015429|FD-Score:3.14|P-value:4.20E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.09|P-value:5.39E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.90|P-value:1.72E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.08|P-value:5.44E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.28|P-value:2.52E-4 ID:SGTC_3135|Compound:9127742|FD-Score:2.97|P-value:7.99E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-2.96|P-value:8.65E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.61|P-value:6.28E-5 ID:SGTC_3193|Compound:9111931|FD-Score:6.18|P-value:2.77E-11 ID:SGTC_3202|Compound:9113761|FD-Score:-3.00|P-value:7.53E-4

Top fitness defect scores for YPL264C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3193 9111931 6.18 49.5 µM 2.77E-11 1 3.20E-10
2 SGTC_2844 9010103 4.92 26.0 µM 8.88E-8 10 4.30E-7
3 SGTC_656 4090-1979 4.56 187.0 µM 6.56E-7 8 2.57E-6
4 SGTC_1246 0422-0085 4.01 105.0 µM 1.06E-5 29 3.09E-5
5 SGTC_2925 9010536 3.90 32.5 µM 1.72E-5 azole & statin 51 4.78E-5
6 SGTC_764 1951-2361 3.86 146.0 µM 2.12E-5 40 5.75E-5
7 SGTC_2606 farnesol 3.77 9.8 µM 3.10E-5 23 8.06E-5
8 SGTC_1177 0983-0204 3.77 23.6 µM 3.16E-5 18 8.21E-5
9 SGTC_1596 piperlongumine 3.74 63.0 µM 3.63E-5 20 9.29E-5
10 SGTC_3192 9110362 3.61 49.5 µM 6.28E-5 mitochondrial processes 16 1.52E-4
11 SGTC_1150 3909-7983 3.51 10.9 µM 9.66E-5 41 2.23E-4
12 SGTC_667 1498-1044 3.49 59.0 µM 1.04E-4 RPP1 & pyrimidine depletion 33 2.39E-4
13 SGTC_3126 9127922 3.28 49.5 µM 2.52E-4 fatty acid desaturase (OLE1) 63 5.27E-4
14 SGTC_2146 5545642 3.15 200.0 µM 4.14E-4 43 8.22E-4
15 SGTC_2850 9015429 3.14 58.4 µM 4.20E-4 45 8.33E-4
16 SGTC_666 0272-0154 3.12 136.0 µM 4.68E-4 cell wall 93 9.17E-4
17 SGTC_1206 3978-0017 3.09 132.0 µM 5.19E-4 ERG2 68 0.00101
18 SGTC_2842 9000675 3.09 19.5 µM 5.24E-4 57 0.00101
19 SGTC_2978 9011784 3.08 43.0 µM 5.44E-4 76 0.00105
20 SGTC_1118 chelidonine 3.07 707.5 nM 5.49E-4 53 0.00106

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.18E-35 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.203 1.64E-32 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.194 6.38E-30 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.188 6.47E-28 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.169 5.35E-23 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165 7.37E-22 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.164 1.53E-21 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.161 6.05E-21 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.161 7.98E-21 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.159 2.29E-20 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.157 6.11E-20 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.155 1.34E-19 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.152 7.43E-19 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.150 2.24E-18 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.149 3.93E-18 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress