YPL270W / MDL2

Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL270W / MDL2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.54|P-value:5.32E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.50|P-value:1.39E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.75|P-value:2.67E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.91|P-value:2.73E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:6.92|P-value:5.38E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:3.75|P-value:2.23E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.50|P-value:5.27E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:4.95E-24 ID:SGTC_448|Compound:monastrol|FD-Score:3.78|P-value:2.05E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.32|P-value:9.38E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:4.67|P-value:6.29E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.31|P-value:9.68E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.37|P-value:2.61E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.11|P-value:6.12E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:8.43|P-value:1.91E-15 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.46|P-value:7.06E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.06|P-value:1.15E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.46|P-value:6.94E-4 ID:SGTC_1558|Compound:st069300|FD-Score:4.18|P-value:4.62E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.05|P-value:8.86E-5 ID:SGTC_1701|Compound:st028638|FD-Score:4.48|P-value:1.41E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.72|P-value:2.97E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.39|P-value:7.63E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.23|P-value:3.90E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.97|P-value:1.71E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-3.60|P-value:4.43E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.00|P-value:9.30E-5 ID:SGTC_2132|Compound:5317594|FD-Score:3.44|P-value:6.38E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.61|P-value:3.61E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.98|P-value:9.89E-5 ID:SGTC_2284|Compound:7945075|FD-Score:5.32|P-value:3.36E-7 ID:SGTC_2349|Compound:9023730|FD-Score:7.52|P-value:1.19E-12 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.53|P-value:1.21E-7 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.53|P-value:4.79E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:14.60|P-value:2.48E-42 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.17|P-value:5.81E-5 ID:SGTC_2959|Compound:9079155|FD-Score:-3.41|P-value:8.12E-4 ID:SGTC_2992|Compound:9074591|FD-Score:5.66|P-value:6.40E-8 ID:SGTC_3005|Compound:9076496|FD-Score:6.42|P-value:1.02E-9 ID:SGTC_3008|Compound:9078912|FD-Score:3.95|P-value:1.08E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-4.80|P-value:4.40E-6 ID:SGTC_3052|Compound:9092717|FD-Score:4.84|P-value:3.13E-6 ID:SGTC_3130|Compound:9127414|FD-Score:4.50|P-value:1.32E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.53|P-value:4.77E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.57|P-value:9.96E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.54|P-value:5.32E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.50|P-value:1.39E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.75|P-value:2.67E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.91|P-value:2.73E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:6.92|P-value:5.38E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:3.75|P-value:2.23E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.50|P-value:5.27E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:4.95E-24 ID:SGTC_448|Compound:monastrol|FD-Score:3.78|P-value:2.05E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.32|P-value:9.38E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:4.67|P-value:6.29E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.31|P-value:9.68E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.37|P-value:2.61E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.11|P-value:6.12E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:8.43|P-value:1.91E-15 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.46|P-value:7.06E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.06|P-value:1.15E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.46|P-value:6.94E-4 ID:SGTC_1558|Compound:st069300|FD-Score:4.18|P-value:4.62E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.05|P-value:8.86E-5 ID:SGTC_1701|Compound:st028638|FD-Score:4.48|P-value:1.41E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.72|P-value:2.97E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.39|P-value:7.63E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.23|P-value:3.90E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.97|P-value:1.71E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-3.60|P-value:4.43E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.00|P-value:9.30E-5 ID:SGTC_2132|Compound:5317594|FD-Score:3.44|P-value:6.38E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.61|P-value:3.61E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.98|P-value:9.89E-5 ID:SGTC_2284|Compound:7945075|FD-Score:5.32|P-value:3.36E-7 ID:SGTC_2349|Compound:9023730|FD-Score:7.52|P-value:1.19E-12 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.53|P-value:1.21E-7 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.53|P-value:4.79E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:14.60|P-value:2.48E-42 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.17|P-value:5.81E-5 ID:SGTC_2959|Compound:9079155|FD-Score:-3.41|P-value:8.12E-4 ID:SGTC_2992|Compound:9074591|FD-Score:5.66|P-value:6.40E-8 ID:SGTC_3005|Compound:9076496|FD-Score:6.42|P-value:1.02E-9 ID:SGTC_3008|Compound:9078912|FD-Score:3.95|P-value:1.08E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-4.80|P-value:4.40E-6 ID:SGTC_3052|Compound:9092717|FD-Score:4.84|P-value:3.13E-6 ID:SGTC_3130|Compound:9127414|FD-Score:4.50|P-value:1.32E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.53|P-value:4.77E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.57|P-value:9.96E-6

Top fitness defect scores for YPL270W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2630 antimycin a 14.60 100.0 µM 2.48E-42 mitochondrial processes 1 1.73E-48
2 SGTC_236 1509-0011 10.80 5.3 µM 4.95E-24 178 2.21E-27
3 SGTC_1205 4161-2785 8.43 76.0 µM 1.91E-15 4 1.72E-17
4 SGTC_2349 9023730 7.52 187.1 µM 1.19E-12 1 2.83E-14
5 SGTC_157 1348-1695 6.92 65.8 µM 5.38E-11 iron homeostasis 15 2.26E-12
6 SGTC_3005 9076496 6.42 71.4 µM 1.02E-9 1 6.61E-11
7 SGTC_2992 9074591 5.66 71.4 µM 6.40E-8 4 7.68E-9
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.53 3.7 µM 1.21E-7 19 1.60E-8
9 SGTC_149 3970-0822 5.50 46.1 µM 1.39E-7 tubulin folding & SWR complex 42 1.87E-8
10 SGTC_1121 fusaric acid 5.37 630.5 nM 2.61E-7 15 3.86E-8
11 SGTC_2284 7945075 5.32 39.2 µM 3.36E-7 mitochondrial processes 8 5.14E-8
12 SGTC_1483 3453-0561 5.06 55.9 µM 1.15E-6 7 2.11E-7
13 SGTC_2049 5262831 4.97 67.2 µM 1.71E-6 12 3.33E-7
14 SGTC_3052 9092717 4.84 49.5 µM 3.13E-6 13 6.63E-7
15 SGTC_880 0833-0487 4.67 87.2 µM 6.29E-6 mitochondrial processes 8 1.48E-6
16 SGTC_3210 9128157 4.57 49.5 µM 9.96E-6 32 2.50E-6
17 SGTC_3130 9127414 4.50 49.5 µM 1.32E-5 14 3.44E-6
18 SGTC_1701 st028638 4.48 40.4 µM 1.41E-5 9 3.71E-6
19 SGTC_2011 4012611 4.23 177.0 µM 3.90E-5 mitochondrial processes 23 1.19E-5
20 SGTC_1558 st069300 4.18 45.6 µM 4.62E-5 9 1.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 4.67E-61 YJR121W ATP2 hom Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.275 2.14E-59 YNL315C ATP11 hom Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
0.246 1.25E-47 YJL180C ATP12 hom Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
0.213 1.01E-35 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.211 3.54E-35 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.208 3.38E-34 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.208 4.96E-34 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.201 7.45E-32 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.200 9.96E-32 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.199 3.52E-31 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.197 9.60E-31 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.194 7.01E-30 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.193 1.65E-29 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.192 2.94E-29 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.190 1.05E-28 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex