YPL271W / ATP15

Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL271W / ATP15

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:-3.65|P-value:3.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.19|P-value:6.25E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.71|P-value:2.42E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.15|P-value:1.16E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.44|P-value:1.54E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.90|P-value:2.20E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.35|P-value:8.07E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.28|P-value:4.44E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.51|P-value:6.82E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.28|P-value:4.58E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.71|P-value:3.54E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.58|P-value:3.82E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.43|P-value:3.20E-7 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.27|P-value:3.03E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:-4.40|P-value:1.83E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.34|P-value:8.35E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.41|P-value:9.53E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.72|P-value:2.33E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.20|P-value:6.05E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.75|P-value:4.23E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.39|P-value:9.92E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.58|P-value:5.48E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.59|P-value:5.30E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.70|P-value:3.66E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.08|P-value:9.51E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.35|P-value:2.21E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.47|P-value:7.66E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.91|P-value:1.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.57|P-value:9.22E-8 ID:SGTC_1847|Compound:st056231|FD-Score:5.45|P-value:2.93E-7 ID:SGTC_1969|Compound:st069479|FD-Score:-4.11|P-value:5.72E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.52|P-value:6.55E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.75|P-value:3.08E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.51|P-value:4.82E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.49|P-value:1.26E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-5.00|P-value:1.45E-6 ID:SGTC_2365|Compound:9042475|FD-Score:4.86|P-value:4.27E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-3.39|P-value:7.10E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.93|P-value:1.10E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.81|P-value:5.35E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.57|P-value:5.61E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.28|P-value:4.49E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.07|P-value:6.52E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.39|P-value:2.99E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.44|P-value:8.42E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.12|P-value:5.25E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-4.91|P-value:2.10E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-3.30|P-value:9.44E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.40|P-value:9.69E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.89|P-value:1.28E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.60|P-value:5.14E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.40|P-value:6.80E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.52|P-value:6.64E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-4.01|P-value:8.18E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.65|P-value:3.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.19|P-value:6.25E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.71|P-value:2.42E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.15|P-value:1.16E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.44|P-value:1.54E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.90|P-value:2.20E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.35|P-value:8.07E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.28|P-value:4.44E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.51|P-value:6.82E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.28|P-value:4.58E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.71|P-value:3.54E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.58|P-value:3.82E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.43|P-value:3.20E-7 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.27|P-value:3.03E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:-4.40|P-value:1.83E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.34|P-value:8.35E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.41|P-value:9.53E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.72|P-value:2.33E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.20|P-value:6.05E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.75|P-value:4.23E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.39|P-value:9.92E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.58|P-value:5.48E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.59|P-value:5.30E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.70|P-value:3.66E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.08|P-value:9.51E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.35|P-value:2.21E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.47|P-value:7.66E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.91|P-value:1.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.57|P-value:9.22E-8 ID:SGTC_1847|Compound:st056231|FD-Score:5.45|P-value:2.93E-7 ID:SGTC_1969|Compound:st069479|FD-Score:-4.11|P-value:5.72E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.52|P-value:6.55E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.75|P-value:3.08E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.51|P-value:4.82E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.49|P-value:1.26E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-5.00|P-value:1.45E-6 ID:SGTC_2365|Compound:9042475|FD-Score:4.86|P-value:4.27E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-3.39|P-value:7.10E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.93|P-value:1.10E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.81|P-value:5.35E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.57|P-value:5.61E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.28|P-value:4.49E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.07|P-value:6.52E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.39|P-value:2.99E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.44|P-value:8.42E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.12|P-value:5.25E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-4.91|P-value:2.10E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-3.30|P-value:9.44E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.40|P-value:9.69E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.89|P-value:1.28E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.60|P-value:5.14E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.40|P-value:6.80E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.52|P-value:6.64E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-4.01|P-value:8.18E-5

Top fitness defect scores for YPL271W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1847 st056231 5.45 15.0 µM 2.93E-7 9 2.57E-8
2 SGTC_1371 2421-0008 5.43 32.7 µM 3.20E-7 mitochondrial processes 8 2.85E-8
3 SGTC_275 trichlorophene 5.15 5.7 µM 1.16E-6 mitochondrial stress 159 1.28E-7
4 SGTC_2365 9042475 4.86 200.0 µM 4.27E-6 17 5.91E-7
5 SGTC_2461 5755302 4.81 26.1 µM 5.35E-6 18 7.70E-7
6 SGTC_2730 imipramine 4.39 71.3 µM 2.99E-5 10 5.76E-6
7 SGTC_582 0987-0078 4.28 156.0 µM 4.44E-5 calcium & mitochondrial duress 56 9.14E-6
8 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.28 13.2 µM 4.49E-5 22 9.28E-6
9 SGTC_818 4072-2707 4.28 53.5 µM 4.58E-5 10 9.48E-6
10 SGTC_1545 lovastatin 4.20 49.4 µM 6.05E-5 18 1.31E-5
11 SGTC_236 1509-0011 4.19 5.3 µM 6.25E-5 369 1.37E-5
12 SGTC_1695 st026914 4.08 34.5 µM 9.51E-5 17 2.23E-5
13 SGTC_2113 5491891 3.75 107.0 µM 3.08E-4 TSC3-RPN4 28 8.81E-5
14 SGTC_832 4083-0019 3.71 164.0 µM 3.54E-4 translation 113 1.04E-4
15 SGTC_1627 st003713 3.70 25.6 µM 3.66E-4 calcium & mitochondrial duress 90 1.08E-4
16 SGTC_3047 9092122 3.60 49.5 µM 5.14E-4 31 1.60E-4
17 SGTC_1624 st003710 3.59 6.2 µM 5.30E-4 calcium & mitochondrial duress 51 1.67E-4
18 SGTC_1597 7-benzyloxygramine 3.58 47.5 µM 5.48E-4 calcium & mitochondrial duress 150 1.73E-4
19 SGTC_2533 agelasine 3.57 13.7 µM 5.61E-4 ERG2 60 1.78E-4
20 SGTC_2024 5144227 3.52 134.0 µM 6.55E-4 50 2.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.291 3.63E-66 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.282 2.55E-62 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.260 1.31E-52 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.257 1.81E-51 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.256 2.87E-51 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.256 5.18E-51 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.251 5.14E-49 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.249 2.52E-48 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.244 2.84E-46 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.241 2.37E-45 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.240 5.30E-45 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit
0.240 8.57E-45 YOR201C MRM1 hom Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
0.234 7.15E-43 YER017C AFG3 hom Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging
0.234 9.28E-43 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.234 1.20E-42 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene