YPR009W / SUT2

Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR009W / SUT2

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:3.46|P-value:4.81E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-3.30|P-value:7.45E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-4.30|P-value:1.75E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.19|P-value:3.20E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.26|P-value:9.44E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.79|P-value:4.24E-11 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-4.42|P-value:1.08E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.37|P-value:1.50E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.36|P-value:6.89E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.54|P-value:7.25E-6 ID:SGTC_1719|Compound:st032227|FD-Score:10.70|P-value:5.57E-25 ID:SGTC_1782|Compound:st039423|FD-Score:3.95|P-value:8.23E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.33|P-value:7.49E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.51|P-value:4.06E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.74|P-value:1.80E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.67|P-value:2.30E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.57|P-value:3.31E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.89|P-value:1.04E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.31|P-value:7.18E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.45|P-value:1.07E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.28|P-value:8.86E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.22|P-value:2.83E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.51|P-value:4.03E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.46|P-value:4.81E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-3.30|P-value:7.45E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-4.30|P-value:1.75E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.19|P-value:3.20E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.26|P-value:9.44E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.79|P-value:4.24E-11 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-4.42|P-value:1.08E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.37|P-value:1.50E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.36|P-value:6.89E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.54|P-value:7.25E-6 ID:SGTC_1719|Compound:st032227|FD-Score:10.70|P-value:5.57E-25 ID:SGTC_1782|Compound:st039423|FD-Score:3.95|P-value:8.23E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.33|P-value:7.49E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.51|P-value:4.06E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.74|P-value:1.80E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.67|P-value:2.30E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.57|P-value:3.31E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.89|P-value:1.04E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.31|P-value:7.18E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.45|P-value:1.07E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.28|P-value:8.86E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.22|P-value:2.83E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.51|P-value:4.03E-4

Top fitness defect scores for YPR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1719 st032227 10.70 49.2 µM 5.57E-25 1 4.11E-27
2 SGTC_1253 0550-0034 6.79 176.0 µM 4.24E-11 2 5.55E-12
3 SGTC_1632 st005650 4.54 90.0 µM 7.25E-6 16 2.79E-6
4 SGTC_2715 st079500 4.45 56.4 µM 1.07E-5 3 4.27E-6
5 SGTC_1476 4112-3294 4.37 3.3 µM 1.50E-5 60S ribosome export 12 6.16E-6
6 SGTC_3331 9141060 4.22 2.0 µM 2.83E-5 cell wall 27 1.23E-5
7 SGTC_572 0960-0087 4.19 17.7 µM 3.20E-5 23 1.40E-5
8 SGTC_1782 st039423 3.95 80.6 µM 8.23E-5 24 3.93E-5
9 SGTC_2258 7960471 3.89 200.0 µM 1.04E-4 11 5.08E-5
10 SGTC_1426 4048-4480 3.88 71.7 µM 1.06E-4 60S ribosome export 16 5.15E-5
11 SGTC_2260 7964312 3.76 200.0 µM 1.68E-4 17 8.52E-5
12 SGTC_1990 st072050 3.74 59.8 µM 1.80E-4 17 9.20E-5
13 SGTC_1900 st060200 3.70 72.8 µM 2.05E-4 27 1.06E-4
14 SGTC_2153 5569715 3.67 200.0 µM 2.30E-4 iron homeostasis 20 1.20E-4
15 SGTC_2244 6635614 3.57 200.0 µM 3.31E-4 9 1.79E-4
16 SGTC_3333 9141820 3.51 12.1 µM 4.03E-4 20 2.21E-4
17 SGTC_1951 sophoraflavanone G 3.51 9.2 µM 4.06E-4 RNA processing & uracil transport 48 2.23E-4
18 SGTC_98 0074-0023 3.46 107.7 µM 4.81E-4 Golgi 59 2.68E-4
19 SGTC_1574 spiramycin 3.36 23.7 µM 6.89E-4 55 3.96E-4
20 SGTC_1898 st060199 3.33 18.6 µM 7.49E-4 28 4.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.31E-12 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.119 5.45E-12 YBR028C YPK3 hom An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
0.115 2.55E-11 YLR341W SPO77 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.111 1.16E-10 YLR415C_p YLR415C_p hom Putative protein of unknown function; YLR415C is not an essential gene
0.110 1.51E-10 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.105 9.64E-10 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.097 1.77E-8 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.092 8.72E-8 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
0.092 1.04E-7 YER169W RPH1 hom JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
0.090 1.80E-7 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.087 3.95E-7 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.085 9.79E-7 YKL218C SRY1 hom 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
0.082 2.29E-6 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.079 5.20E-6 YGL258W VEL1 hom Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C
0.076 1.13E-5 YIL047C SYG1 hom Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency