YPR013C_p / CMR3

Putative zinc finger protein; YPR013C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR013C / CMR3

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.58|P-value:1.12E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.20|P-value:5.04E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.32|P-value:3.02E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.22|P-value:4.45E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.33|P-value:3.01E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.48|P-value:1.63E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.09|P-value:7.52E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.97|P-value:2.10E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.48|P-value:1.63E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.19|P-value:5.11E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.07|P-value:7.72E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.49|P-value:1.70E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.21|P-value:4.59E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.03|P-value:8.78E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.16|P-value:5.61E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.21|P-value:4.72E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.71|P-value:6.85E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.56|P-value:1.27E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-4.84|P-value:3.18E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.60|P-value:1.03E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.52|P-value:1.42E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.06|P-value:8.39E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.36|P-value:2.73E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.07|P-value:8.12E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.86|P-value:3.49E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-3.54|P-value:1.38E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.76|P-value:5.32E-5 ID:SGTC_2853|Compound:9015042|FD-Score:5.49|P-value:7.52E-9 ID:SGTC_2854|Compound:9024559|FD-Score:3.21|P-value:4.67E-4 ID:SGTC_2857|Compound:9024691|FD-Score:14.80|P-value:4.05E-53 ID:SGTC_2858|Compound:9025781|FD-Score:-7.91|P-value:2.02E-16 ID:SGTC_2927|Compound:9011802|FD-Score:5.13|P-value:6.08E-8 ID:SGTC_2943|Compound:9068529|FD-Score:-3.33|P-value:3.09E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.29|P-value:3.40E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.10|P-value:7.04E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.11|P-value:7.01E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.29|P-value:3.59E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.08|P-value:1.27E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.03|P-value:9.07E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.58|P-value:1.12E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.20|P-value:5.04E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.32|P-value:3.02E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.22|P-value:4.45E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.33|P-value:3.01E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.48|P-value:1.63E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.09|P-value:7.52E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.97|P-value:2.10E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.48|P-value:1.63E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.19|P-value:5.11E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.07|P-value:7.72E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.49|P-value:1.70E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.21|P-value:4.59E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.03|P-value:8.78E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.16|P-value:5.61E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.21|P-value:4.72E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.71|P-value:6.85E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.56|P-value:1.27E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-4.84|P-value:3.18E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.60|P-value:1.03E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.52|P-value:1.42E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.06|P-value:8.39E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.36|P-value:2.73E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.07|P-value:8.12E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.86|P-value:3.49E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-3.54|P-value:1.38E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.76|P-value:5.32E-5 ID:SGTC_2853|Compound:9015042|FD-Score:5.49|P-value:7.52E-9 ID:SGTC_2854|Compound:9024559|FD-Score:3.21|P-value:4.67E-4 ID:SGTC_2857|Compound:9024691|FD-Score:14.80|P-value:4.05E-53 ID:SGTC_2858|Compound:9025781|FD-Score:-7.91|P-value:2.02E-16 ID:SGTC_2927|Compound:9011802|FD-Score:5.13|P-value:6.08E-8 ID:SGTC_2943|Compound:9068529|FD-Score:-3.33|P-value:3.09E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.29|P-value:3.40E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.10|P-value:7.04E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.11|P-value:7.01E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.29|P-value:3.59E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.08|P-value:1.27E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.03|P-value:9.07E-4

Top fitness defect scores for YPR013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2857 9024691 14.80 58.4 µM 4.05E-53 1 3.58E-50
2 SGTC_2853 9015042 5.49 58.4 µM 7.52E-9 9 1.99E-8
3 SGTC_2927 9011802 5.13 47.9 µM 6.08E-8 10 1.43E-7
4 SGTC_3328 9140624 4.08 29.0 µM 1.27E-5 18 2.22E-5
5 SGTC_580 1123-0028 3.97 41.0 µM 2.10E-5 DNA damage response 36 3.56E-5
6 SGTC_2427 5545055 3.86 42.8 µM 3.49E-5 16 5.75E-5
7 SGTC_2563 tomatine 3.76 8.5 µM 5.32E-5 57 8.57E-5
8 SGTC_1798 st045719 3.60 61.0 µM 1.03E-4 16 1.60E-4
9 SGTC_20 0481-0013 3.58 4.9 µM 1.12E-4 37 1.73E-4
10 SGTC_994 3910-0338 3.54 138.0 µM 1.31E-4 calcium & mitochondrial duress 64 2.01E-4
11 SGTC_2276 7947513 3.52 42.1 µM 1.42E-4 32 2.17E-4
12 SGTC_572 0960-0087 3.48 17.7 µM 1.63E-4 46 2.46E-4
13 SGTC_595 3909-8003 3.48 73.7 µM 1.63E-4 26 2.47E-4
14 SGTC_2330 7979373 3.44 200.0 µM 1.97E-4 60S ribosome export 46 2.95E-4
15 SGTC_500 h-89 3.33 112.0 µM 3.01E-4 cell wall signaling 51 4.41E-4
16 SGTC_438 sphingosine 3.32 6.7 µM 3.02E-4 38 4.43E-4
17 SGTC_3200 9114385 3.29 49.5 µM 3.40E-4 67 4.94E-4
18 SGTC_464 bw-b 70c 3.22 158.0 µM 4.45E-4 55 6.38E-4
19 SGTC_1365 1672-3266 3.21 55.4 µM 4.59E-4 50 6.56E-4
20 SGTC_2854 9024559 3.21 71.4 µM 4.67E-4 55 6.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 1.14E-27 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.157 7.26E-20 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.148 5.79E-18 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.139 6.63E-16 YIR017C MET28 hom Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
0.135 4.04E-15 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.122 1.63E-12 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.120 2.79E-12 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.120 3.72E-12 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.116 1.85E-11 YBR057C MUM2 hom Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
0.114 3.40E-11 YLR281C_p YLR281C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.111 1.08E-10 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.110 1.80E-10 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.109 2.31E-10 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.104 1.74E-9 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.102 3.21E-9 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio