HIPHOP chemogenomics database

YPR024W / YME1

Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR024W / YME1

Click on Significant Values for Screen Details

Top fitness defect scores for YPR024W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_67	0335-0847	23.00	266.0 µM	3.04E-130	ubiquinone biosynthesis & proteasome	2	2.02E-117
2	SGTC_64	000l-0018	11.70	272.1 µM	1.26E-35	ubiquinone biosynthesis & proteasome	31	3.97E-32
3	SGTC_158	k038-0087	11.70	26.4 µM	1.84E-35	ubiquinone biosynthesis & proteasome	22	5.55E-32
4	SGTC_236	1509-0011	11.30	5.3 µM	5.51E-33		168	9.45E-30
5	SGTC_163	1327-0036	10.60	7.5 µM	1.27E-29		12	1.01E-26
6	SGTC_36	0335-0881	8.82	14.2 µM	5.13E-21	ubiquinone biosynthesis & proteasome	27	5.61E-19
7	SGTC_852	0418-0143	8.40	439.0 µM	3.21E-19	calcium & mitochondrial duress	11	2.32E-17
8	SGTC_200	k038-0079	6.52	37.5 µM	2.47E-12	ubiquinone biosynthesis & proteasome	23	3.61E-11
9	SGTC_743	1275-0778	6.40	158.0 µM	5.65E-12	excess fatty acid	10	7.59E-11
10	SGTC_2349	9023730	5.69	187.1 µM	7.90E-10		4	6.44E-9
11	SGTC_165	k038-0023	5.19	64.4 µM	1.79E-8	ubiquinone biosynthesis & proteasome	38	1.06E-7
12	SGTC_310	1273-0058	4.94	1.1 µM	7.73E-8	mitochondrial stress	186	3.95E-7
13	SGTC_795	0685-0265	4.83	78.0 µM	1.40E-7	excess fatty acid	11	6.76E-7
14	SGTC_2541	muurolladie-3-one	4.76	83.1 µM	2.11E-7	excess fatty acid	13	9.73E-7
15	SGTC_2415	st077333	4.69	57.7 µM	3.08E-7		26	1.37E-6
16	SGTC_142	0335-0849	4.58	62.7 µM	5.54E-7	ubiquinone biosynthesis & proteasome	100	2.32E-6
17	SGTC_2176	5809774	4.57	34.0 µM	5.74E-7	mitochondrial processes	7	2.39E-6
18	SGTC_1199	1638-0010	4.34	4.5 µM	1.92E-6	endomembrane recycling	12	7.09E-6
19	SGTC_1475	4092-1048	4.31	11.7 µM	2.26E-6	plasma membrane duress	22	8.20E-6
20	SGTC_2429	5902844	4.15	64.4 µM	4.86E-6		19	1.63E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.582	1.16E-302	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.575	1.70E-294	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.573	1.40E-291	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.534	1.09E-246	YOR125C	CAT5	hom	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.525	3.99E-237	YBR003W	COQ1	hom	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.512	1.10E-223	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.490	2.38E-202	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.479	2.57E-191	YDR148C	KGD2	hom	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.478	9.65E-191	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.471	1.33E-184	YOL096C	COQ3	hom	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.464	1.54E-178	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.452	4.35E-168	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.451	1.14E-167	YJL168C	SET2	hom	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.402	3.59E-130	YLR202C_d	YLR202C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.393	1.64E-124	YML110C	COQ5	hom	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes