YPR032W / SRO7

Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR032W / SRO7

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.93|P-value:8.04E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.46|P-value:3.73E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.68|P-value:2.64E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.46|P-value:3.78E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:4.92|P-value:8.72E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.24|P-value:1.86E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:3.32|P-value:6.06E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.22|P-value:8.48E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.18|P-value:2.37E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:4.22|P-value:2.02E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:6.91|P-value:9.56E-12 ID:SGTC_339|Compound:3091-4833|FD-Score:3.83|P-value:9.44E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.38|P-value:4.95E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:6.13|P-value:1.29E-9 ID:SGTC_907|Compound:3448-6986|FD-Score:3.79|P-value:1.13E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.98|P-value:5.26E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.05|P-value:4.07E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.31|P-value:1.34E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.50|P-value:3.24E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.34|P-value:1.19E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.61|P-value:2.20E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:12.60|P-value:2.01E-34 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.45|P-value:7.60E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.36|P-value:1.22E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:13.50|P-value:1.41E-39 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.04|P-value:4.21E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.06|P-value:3.87E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.44|P-value:4.78E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.57|P-value:2.56E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.44|P-value:4.06E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.27|P-value:1.61E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.55|P-value:3.29E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.63|P-value:2.04E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.34|P-value:5.59E-4 ID:SGTC_1938|Compound:st074717|FD-Score:4.39|P-value:9.75E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-5.34|P-value:1.39E-7 ID:SGTC_2012|Compound:4023501|FD-Score:-6.15|P-value:1.52E-9 ID:SGTC_2087|Compound:5276107|FD-Score:-5.08|P-value:4.92E-7 ID:SGTC_2090|Compound:5301565|FD-Score:6.09|P-value:1.63E-9 ID:SGTC_2097|Compound:5376186|FD-Score:3.69|P-value:1.64E-4 ID:SGTC_2098|Compound:5376439|FD-Score:-3.27|P-value:8.49E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.56|P-value:2.58E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.80|P-value:1.55E-6 ID:SGTC_2258|Compound:7960471|FD-Score:3.50|P-value:3.23E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.63|P-value:3.27E-6 ID:SGTC_2399|Compound:5884133|FD-Score:3.66|P-value:1.82E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.43|P-value:8.25E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.97|P-value:3.27E-9 ID:SGTC_2426|Compound:5582046|FD-Score:-3.95|P-value:7.45E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.32|P-value:6.04E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.61|P-value:2.22E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.30|P-value:6.49E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:6.33|P-value:3.98E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.68|P-value:1.68E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:7.07|P-value:3.23E-12 ID:SGTC_2602|Compound:kawain|FD-Score:5.16|P-value:2.68E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.26|P-value:1.61E-7 ID:SGTC_3083|Compound:9117465|FD-Score:4.34|P-value:1.21E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.76|P-value:1.24E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.56|P-value:4.57E-6 ID:SGTC_3139|Compound:9095020|FD-Score:4.32|P-value:1.31E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.46|P-value:4.41E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-7.81|P-value:2.57E-14 ID:SGTC_3157|Compound:9099274|FD-Score:3.59|P-value:2.31E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.93|P-value:8.04E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.46|P-value:3.73E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.68|P-value:2.64E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.46|P-value:3.78E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:4.92|P-value:8.72E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.24|P-value:1.86E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:3.32|P-value:6.06E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.22|P-value:8.48E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.18|P-value:2.37E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:4.22|P-value:2.02E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:6.91|P-value:9.56E-12 ID:SGTC_339|Compound:3091-4833|FD-Score:3.83|P-value:9.44E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.38|P-value:4.95E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:6.13|P-value:1.29E-9 ID:SGTC_907|Compound:3448-6986|FD-Score:3.79|P-value:1.13E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.98|P-value:5.26E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.05|P-value:4.07E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.31|P-value:1.34E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.50|P-value:3.24E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.34|P-value:1.19E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.61|P-value:2.20E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:12.60|P-value:2.01E-34 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.45|P-value:7.60E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.36|P-value:1.22E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:13.50|P-value:1.41E-39 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.04|P-value:4.21E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.06|P-value:3.87E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.44|P-value:4.78E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.57|P-value:2.56E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.44|P-value:4.06E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.27|P-value:1.61E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.55|P-value:3.29E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.63|P-value:2.04E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.34|P-value:5.59E-4 ID:SGTC_1938|Compound:st074717|FD-Score:4.39|P-value:9.75E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-5.34|P-value:1.39E-7 ID:SGTC_2012|Compound:4023501|FD-Score:-6.15|P-value:1.52E-9 ID:SGTC_2087|Compound:5276107|FD-Score:-5.08|P-value:4.92E-7 ID:SGTC_2090|Compound:5301565|FD-Score:6.09|P-value:1.63E-9 ID:SGTC_2097|Compound:5376186|FD-Score:3.69|P-value:1.64E-4 ID:SGTC_2098|Compound:5376439|FD-Score:-3.27|P-value:8.49E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.56|P-value:2.58E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.80|P-value:1.55E-6 ID:SGTC_2258|Compound:7960471|FD-Score:3.50|P-value:3.23E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.63|P-value:3.27E-6 ID:SGTC_2399|Compound:5884133|FD-Score:3.66|P-value:1.82E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.43|P-value:8.25E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.97|P-value:3.27E-9 ID:SGTC_2426|Compound:5582046|FD-Score:-3.95|P-value:7.45E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.32|P-value:6.04E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.61|P-value:2.22E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.30|P-value:6.49E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:6.33|P-value:3.98E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.68|P-value:1.68E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:7.07|P-value:3.23E-12 ID:SGTC_2602|Compound:kawain|FD-Score:5.16|P-value:2.68E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.26|P-value:1.61E-7 ID:SGTC_3083|Compound:9117465|FD-Score:4.34|P-value:1.21E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.76|P-value:1.24E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.56|P-value:4.57E-6 ID:SGTC_3139|Compound:9095020|FD-Score:4.32|P-value:1.31E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.46|P-value:4.41E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-7.81|P-value:2.57E-14 ID:SGTC_3157|Compound:9099274|FD-Score:3.59|P-value:2.31E-4

Top fitness defect scores for YPR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1249 0481-0015 13.50 10.2 µM 1.41E-39 1 5.42E-42
2 SGTC_1242 0402-0103 12.60 60.1 µM 2.01E-34 1 1.69E-36
3 SGTC_2595 hexamethylquercetagetin 7.07 100.0 µM 3.23E-12 2 7.50E-13
4 SGTC_317 4495-0002 6.91 170.0 µM 9.56E-12 3 2.38E-12
5 SGTC_2572 astragaloside iv 6.33 100.0 µM 3.98E-10 2 1.25E-10
6 SGTC_705 1124-0212 6.13 310.0 µM 1.29E-9 2 4.35E-10
7 SGTC_2090 5301565 6.09 104.5 µM 1.63E-9 TSC3-RPN4 18 5.59E-10
8 SGTC_2422 chlorphenesin carbamate 5.97 384.2 µM 3.27E-9 4 1.17E-9
9 SGTC_2737 bleomycin 5.26 30.5 nM 1.61E-7 Golgi 42 7.35E-8
10 SGTC_2602 kawain 5.16 100.0 µM 2.68E-7 6 1.26E-7
11 SGTC_18 0111-0177 4.93 500.0 nM 8.04E-7 39 4.05E-7
12 SGTC_84 0443-0269 4.92 128.8 µM 8.72E-7 9 4.41E-7
13 SGTC_2217 6934799 4.80 96.1 µM 1.55E-6 TSC3-RPN4 2 8.10E-7
14 SGTC_20 0481-0013 4.68 4.9 µM 2.64E-6 12 1.43E-6
15 SGTC_2325 6158266 4.63 200.0 µM 3.27E-6 13 1.79E-6
16 SGTC_3136 9095672 4.56 49.5 µM 4.57E-6 12 2.55E-6
17 SGTC_1246 0422-0085 4.45 105.0 µM 7.60E-6 17 4.38E-6
18 SGTC_2410 aloe-emodin-8-o-glycoside 4.43 46.3 µM 8.25E-6 mitochondrial processes 17 4.77E-6
19 SGTC_1938 st074717 4.39 56.4 µM 9.75E-6 7 5.70E-6
20 SGTC_1075 aripiprazole 4.34 15.2 µM 1.19E-5 18 7.06E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 7.66E-9 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.099 9.82E-9 YMR192W GYL1 hom Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.097 2.09E-8 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.095 3.29E-8 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.095 3.93E-8 YKL125W RRN3 het Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
0.095 3.95E-8 YCR087W_d YCR087W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
0.092 8.04E-8 YLR325C RPL38 hom Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog
0.086 6.47E-7 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
0.086 6.78E-7 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.085 9.28E-7 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.085 9.86E-7 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.084 1.22E-6 YMR049C ERB1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
0.083 1.35E-6 YMR227C TAF7 het TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.082 1.92E-6 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.081 2.91E-6 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11