HIPHOP chemogenomics database

YPR050C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR050C / YPR050C

Click on Significant Values for Screen Details

Top fitness defect scores for YPR050C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_124	0136-0217	12.50	7.1 µM	6.60E-28	mitochondrial stress	5	2.10E-36
2	SGTC_528	3492-0019	11.50	172.0 µM	1.40E-23	calcium & mitochondrial duress	33	1.11E-30
3	SGTC_430	0958-0115	9.63	16.4 µM	3.34E-17		2	3.02E-22
4	SGTC_2752	diclazuril	8.32	33.1 µM	2.71E-13		31	4.42E-17
5	SGTC_574	1315-0397	7.01	40.0 µM	6.01E-10		2	1.15E-12
6	SGTC_119	0121-0043	5.63	24.8 µM	5.37E-7	mitochondrial stress	31	8.97E-9
7	SGTC_572	0960-0087	5.29	17.7 µM	2.35E-6		5	6.25E-8
8	SGTC_2153	5569715	5.26	200.0 µM	2.67E-6	iron homeostasis	9	7.40E-8
9	SGTC_937	3122-0005	5.20	46.7 µM	3.32E-6		13	9.85E-8
10	SGTC_3013	9080133	4.85	71.4 µM	1.33E-5		6	6.13E-7
11	SGTC_2110	5483698	4.74	200.0 µM	2.02E-5	TSC3-RPN4	13	1.05E-6
12	SGTC_3335	9143315	4.58	29.6 µM	3.71E-5	fatty acid desaturase (OLE1)	6	2.35E-6
13	SGTC_1947	st076332	4.52	61.6 µM	4.58E-5		10	3.09E-6
14	SGTC_581	0958-0271	4.33	211.0 µM	8.98E-5		41	7.49E-6
15	SGTC_681	1642-0006	4.30	26.6 µM	1.00E-4		2	8.65E-6
16	SGTC_1632	st005650	4.29	90.0 µM	1.02E-4		19	8.88E-6
17	SGTC_2379	9035213	4.21	200.0 µM	1.33E-4		15	1.25E-5
18	SGTC_3005	9076496	4.15	71.4 µM	1.63E-4		5	1.63E-5
19	SGTC_240	5hr heat shock (37°C) + Streptovitacin	4.14	300.0 µM	1.73E-4	heat shock/prefoldin	32	1.77E-5
20	SGTC_999	4022-0066	4.13	22.7 µM	1.79E-4	Golgi	35	1.85E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.273	2.39E-58	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.260	5.80E-53	YLL040C	VPS13	hom	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.231	6.62E-42	YOR109W	INP53	hom	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.210	1.14E-34	YDR093W	DNF2	hom	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.206	1.71E-33	YEL053C	MAK10	hom	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.170	2.73E-23	YOR086C	TCB1	hom	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.169	4.99E-23	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.157	7.11E-20	YIL170W	HXT12	hom	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.157	7.59E-20	YOR068C	VAM10	hom	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.155	1.93E-19	YNL264C	PDR17	hom	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.154	3.62E-19	YLR404W	FLD1	hom	Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.153	3.94E-19	YPR051W	MAK3	hom	Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
0.145	3.67E-17	YBL051C	PIN4	hom	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.141	2.09E-16	YDR095C_d	YDR095C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141	2.78E-16	YDL019C	OSH2	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability