YPR053C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR053C / YPR053C

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-3.50|P-value:1.58E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.77|P-value:3.81E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.27|P-value:5.65E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.59|P-value:9.78E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.16|P-value:5.81E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.09|P-value:6.64E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-7.09|P-value:1.36E-13 ID:SGTC_375|Compound:3970-0961|FD-Score:3.21|P-value:4.34E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-4.89|P-value:2.43E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.63|P-value:8.22E-5 ID:SGTC_393|Compound:acivicin|FD-Score:4.93|P-value:1.63E-7 ID:SGTC_470|Compound:aa-861|FD-Score:3.43|P-value:1.84E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.61|P-value:8.94E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.05|P-value:8.62E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.61|P-value:8.88E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.31|P-value:3.28E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.61|P-value:8.75E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.17|P-value:4.90E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.20|P-value:4.42E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.02|P-value:8.53E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.02|P-value:9.84E-8 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.02|P-value:8.60E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.66|P-value:7.44E-5 ID:SGTC_1853|Compound:st056710|FD-Score:-4.46|P-value:2.16E-6 ID:SGTC_1855|Compound:st056195|FD-Score:-3.88|P-value:3.24E-5 ID:SGTC_1856|Compound:st057054|FD-Score:-4.12|P-value:1.13E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.82|P-value:4.17E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.32|P-value:2.82E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.43|P-value:2.13E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.54|P-value:1.35E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.54|P-value:1.18E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.05|P-value:7.70E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.16|P-value:5.26E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.62|P-value:8.72E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.09|P-value:6.73E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.74|P-value:1.38E-9 ID:SGTC_2469|Compound:5655019|FD-Score:4.18|P-value:7.30E-6 ID:SGTC_2470|Compound:5664817|FD-Score:3.07|P-value:7.20E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.32|P-value:3.77E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.75|P-value:5.11E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.67|P-value:7.14E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.16|P-value:5.86E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.25|P-value:3.70E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.17|P-value:5.01E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.86|P-value:3.09E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.34|P-value:2.60E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.07|P-value:7.90E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.15|P-value:6.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.08|P-value:6.87E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.25|P-value:3.72E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-6.31|P-value:4.11E-11 ID:SGTC_2980|Compound:9014342|FD-Score:3.98|P-value:1.79E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.05|P-value:7.79E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.14|P-value:5.60E-4 ID:SGTC_3171|Compound:9103192|FD-Score:2.99|P-value:9.51E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.30|P-value:4.05E-6 ID:SGTC_3238|Compound:9133470|FD-Score:3.04|P-value:7.94E-4 ID:SGTC_3251|Compound:9135047|FD-Score:-3.47|P-value:1.83E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.85|P-value:3.26E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.04|P-value:7.91E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.50|P-value:1.58E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.77|P-value:3.81E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.27|P-value:5.65E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.59|P-value:9.78E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.16|P-value:5.81E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.09|P-value:6.64E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-7.09|P-value:1.36E-13 ID:SGTC_375|Compound:3970-0961|FD-Score:3.21|P-value:4.34E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-4.89|P-value:2.43E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.63|P-value:8.22E-5 ID:SGTC_393|Compound:acivicin|FD-Score:4.93|P-value:1.63E-7 ID:SGTC_470|Compound:aa-861|FD-Score:3.43|P-value:1.84E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.61|P-value:8.94E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.05|P-value:8.62E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.61|P-value:8.88E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.31|P-value:3.28E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.61|P-value:8.75E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.17|P-value:4.90E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.20|P-value:4.42E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.02|P-value:8.53E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.02|P-value:9.84E-8 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.02|P-value:8.60E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.66|P-value:7.44E-5 ID:SGTC_1853|Compound:st056710|FD-Score:-4.46|P-value:2.16E-6 ID:SGTC_1855|Compound:st056195|FD-Score:-3.88|P-value:3.24E-5 ID:SGTC_1856|Compound:st057054|FD-Score:-4.12|P-value:1.13E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.82|P-value:4.17E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.32|P-value:2.82E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.43|P-value:2.13E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.54|P-value:1.35E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.54|P-value:1.18E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.05|P-value:7.70E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.16|P-value:5.26E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.62|P-value:8.72E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.09|P-value:6.73E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.74|P-value:1.38E-9 ID:SGTC_2469|Compound:5655019|FD-Score:4.18|P-value:7.30E-6 ID:SGTC_2470|Compound:5664817|FD-Score:3.07|P-value:7.20E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.32|P-value:3.77E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.75|P-value:5.11E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.67|P-value:7.14E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.16|P-value:5.86E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.25|P-value:3.70E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.17|P-value:5.01E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.86|P-value:3.09E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.34|P-value:2.60E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.07|P-value:7.90E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.15|P-value:6.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.08|P-value:6.87E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.25|P-value:3.72E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-6.31|P-value:4.11E-11 ID:SGTC_2980|Compound:9014342|FD-Score:3.98|P-value:1.79E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.05|P-value:7.79E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.14|P-value:5.60E-4 ID:SGTC_3171|Compound:9103192|FD-Score:2.99|P-value:9.51E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.30|P-value:4.05E-6 ID:SGTC_3238|Compound:9133470|FD-Score:3.04|P-value:7.94E-4 ID:SGTC_3251|Compound:9135047|FD-Score:-3.47|P-value:1.83E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.85|P-value:3.26E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.04|P-value:7.91E-4

Top fitness defect scores for YPR053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2431 5490079 5.74 200.0 µM 1.38E-9 10 4.74E-9
2 SGTC_1510 1123-0200 5.02 71.5 µM 9.84E-8 24 2.58E-7
3 SGTC_393 acivicin 4.93 6.2 µM 1.63E-7 12 4.14E-7
4 SGTC_58 0957-0393 4.77 9.0 µM 3.81E-7 cell wall 309 9.17E-7
5 SGTC_1394 3474-0001 4.61 65.7 µM 8.75E-7 endomembrane recycling 26 2.00E-6
6 SGTC_2523 spermine 4.32 47.7 µM 3.77E-6 calcium & mitochondrial duress 23 7.84E-6
7 SGTC_3182 9108849 4.30 49.5 µM 4.05E-6 RPP1 & pyrimidine depletion 8 8.38E-6
8 SGTC_2469 5655019 4.18 90.8 µM 7.30E-6 19 1.46E-5
9 SGTC_2980 9014342 3.98 25.3 µM 1.79E-5 35 3.38E-5
10 SGTC_2788 5282734 3.86 71.4 µM 3.09E-5 51 5.62E-5
11 SGTC_3279 9140807 3.85 49.5 µM 3.26E-5 15 5.91E-5
12 SGTC_2597 laccaic acid a 3.75 100.0 µM 5.11E-5 39 9.00E-5
13 SGTC_2601 securinine 3.67 100.0 µM 7.14E-5 37 1.23E-4
14 SGTC_1578 josamycin 3.66 24.2 µM 7.44E-5 19 1.28E-4
15 SGTC_387 norethindrone acetate 3.63 66.7 µM 8.22E-5 25 1.41E-4
16 SGTC_2336 9001819 3.62 198.7 µM 8.72E-5 heme biosynthesis & mitochondrial translocase 68 1.49E-4
17 SGTC_981 1488-1094 3.61 54.9 µM 8.88E-5 30 1.51E-4
18 SGTC_811 0416-0114 3.61 265.0 µM 8.94E-5 37 1.52E-4
19 SGTC_145 3737-0113 3.59 38.4 µM 9.78E-5 DNA intercalators 94 1.65E-4
20 SGTC_2809 7964133 3.55 13.0 µM 1.14E-4 60S ribosome export 55 1.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.88E-13 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.118 6.34E-12 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.114 3.89E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.112 6.61E-11 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.104 1.68E-9 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.102 3.56E-9 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.101 4.18E-9 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.53E-8 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.093 5.76E-8 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.091 1.12E-7 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.091 1.30E-7 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.090 1.99E-7 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.088 3.74E-7 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.086 5.25E-7 YCR026C NPP1 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication
0.086 5.79E-7 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains