HIPHOP chemogenomics database

YPR059C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR059C / YPR059C

Click on Significant Values for Screen Details

Top fitness defect scores for YPR059C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1470	k295-0292	7.82	231.0 µM	4.49E-15		2	2.73E-15
2	SGTC_2851	9015922	7.16	71.4 µM	6.09E-13		5	3.89E-13
3	SGTC_184	1494-0393	7.16	24.7 µM	6.11E-13		11	3.91E-13
4	SGTC_428	3448-4153	7.11	16.5 µM	9.22E-13	TSC3-RPN4	2	5.92E-13
5	SGTC_42	0133-0086	6.07	60.6 µM	9.30E-10		3	6.41E-10
6	SGTC_1107	amlodipine	5.84	47.0 µM	3.72E-9		5	2.61E-9
7	SGTC_2166	5933061	5.63	31.5 µM	1.25E-8	tubulin folding & SWR complex	16	8.92E-9
8	SGTC_3057	9095946	5.56	49.5 µM	1.87E-8	Golgi	4	1.33E-8
9	SGTC_66	0109-0187	5.40	42.4 µM	4.71E-8		17	3.40E-8
10	SGTC_1926	methyl fluorone black	5.34	53.6 µM	6.37E-8	DNA intercalators	27	4.62E-8
11	SGTC_78	0336-0123	5.07	156.8 µM	2.70E-7		12	1.99E-7
12	SGTC_145	3737-0113	4.97	38.4 µM	4.58E-7	DNA intercalators	45	3.40E-7
13	SGTC_3264	9137442	4.86	49.5 µM	7.71E-7		6	5.76E-7
14	SGTC_2317	5986382	4.78	200.0 µM	1.16E-6		3	8.73E-7
15	SGTC_2363	9053361	4.74	176.0 µM	1.40E-6	Golgi	19	1.05E-6
16	SGTC_471	1-acyl-paf	4.73	4.0 µM	1.47E-6	DNA intercalators	17	1.11E-6
17	SGTC_1459	k035-0031	4.59	35.7 µM	2.88E-6	DNA intercalators	12	2.19E-6
18	SGTC_2114	5491910	4.59	81.2 µM	2.96E-6		4	2.25E-6
19	SGTC_1970	st070122	4.55	35.8 µM	3.46E-6	TSC3-RPN4	19	2.63E-6
20	SGTC_1493	4348-0038	4.54	111.0 µM	3.62E-6	RSC complex & mRNA processing	13	2.76E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.202	3.71E-32	YPL035C_d	YPL035C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.196	2.00E-30	YMR044W	IOC4	hom	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.186	1.47E-27	YHR149C	SKG6	hom	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.183	1.61E-26	YBR182C-A_p	YBR182C-A_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.169	6.35E-23	YEL017C-A	PMP2	hom	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.157	6.87E-20	YPL197C_d	YPL197C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.156	1.31E-19	YEL064C	AVT2	hom	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.153	4.80E-19	YIL144W	TID3	het	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.151	1.47E-18	YOL035C_d	YOL035C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148	8.12E-18	YGR156W	PTI1	het	Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.146	1.66E-17	YER099C	PRS2	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.144	6.74E-17	YDR524W-C_p	YDR524W-C_p	hom	Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.143	8.42E-17	YML047W-A_d	YML047W-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142	1.76E-16	YKR064W	OAF3	hom	Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.140	4.33E-16	YMR030W	RSF1	hom	Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes